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Passive transfer of experimental allergic encephalomyelitis induced by proteolipid apoprotein.

Abstract：

:In an attempt to obtain insight into the pathogenesis of proteolipid apoprotein (PLP)-induced experimental allergic encephalomyelitis (EAE) in Lewis rats (Yamamura et al. 1986), PLP-sensitized lymph node cells or spleen cells were passively transferred into normal or irradiated (400 rad) recipients after incubation with concanavalin A or PLP. Clinical EAE manifested by paraparesis was successfully transferred into irradiated recipients with 2 - 2.5 X 10(8) of the primary cultured cells and histologic EAE could be transferred with as few as 5 X 10(7) cells into naive recipients. This is the first demonstration of passive EAE induced with PLP-sensitized lymphoid cells and suggests the pathogenetic importance of cell-mediated immunity to PLP.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Yamamura T,Namikawa T,Endoh M,Kunishita T,Tabira T

doi

10.1016/0022-510x(86)90174-7

subject

Has Abstract

pub_date

1986-12-01 00:00:00

pages

269-75

issue

2-3

eissn

0022-510X

issn

1878-5883

pii

0022-510X(86)90174-7

journal_volume

76

pub_type

杂志文章

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