Comparison of nifedipine, prazosin and hydralazine added to treatment of hypertensive patients uncontrolled by thiazide diuretic plus beta-blocker.

Abstract:

:In 93 patients with hypertension uncontrolled by bendrofluazide 5 mg plus atenolol 100 mg daily, the effects of adding nifedipine (up to 60 mg/day, n = 31), prazosin (up to 20 mg/day, n = 31), or hydralazine (up to 200 mg/day, n = 31) were compared in a 6 month open random parallel group study. The three drugs did not differ significantly as regards antihypertensive effect, withdrawal rate, total number of side effects, or effect on serum biochemical variables. The pattern of side-effects differed. Headache, flushing and oedema were common with nifedipine, tiredness and drowsiness with prazosin, and headache with hydralazine. Nifedipine is an acceptable third-line antihypertensive drug which may have some advantage over hydralazine and prazosin.

journal_name

Postgrad Med J

authors

Ramsay LE,Parnell L,Waller PC

doi

10.1136/pgmj.63.736.99

subject

Has Abstract

pub_date

1987-02-01 00:00:00

pages

99-103

issue

736

eissn

0032-5473

issn

1469-0756

journal_volume

63

pub_type

临床试验,杂志文章,随机对照试验
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