Does splenectomy predispose to meningococcal sepsis? An experimental study and clinical review.

Abstract:

:Splenectomy is a recognized factor predisposing to the late complication of serious sepsis. The meningococcus has been listed as an important organism in postsplenectomy infection. A survey of the literature, however, revealed a total of only 13 documented case reports over a 31-year period, including ten pediatric cases. No documented cases of meningococcal sepsis in children following splenectomy for trauma were found. In an experimental mouse meningococcal infection model, the intraperitoneal LD50 was similar between normal and splenectomized mice (4 X 10(8) v 4 X 10(7) cfu, respectively; P = not significant). Bacteremic patterns were similar in both groups. Uniform survival was seen in normal and splenectomized mice after various intravenous challenge doses of meningococci up to 10(6) cfu. This was associated with efficient bacterial clearance in both groups. It appears unlikely that the defect resulting from splenectomy alone is an important predisposing factor in meningococcal sepsis.

journal_name

J Pediatr Surg

authors

Loggie BW,Hinchey EJ

doi

10.1016/s0022-3468(86)80195-6

subject

Has Abstract

pub_date

1986-04-01 00:00:00

pages

326-30

issue

4

eissn

0022-3468

issn

1531-5037

pii

S0022346886001732

journal_volume

21

pub_type

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