Growth failure and decreased levels of insulin-like growth factor I in obstructive jaundice are reversed by bile diversion.

Abstract:

:Insulin-like growth factor I (IGF-I) is one of the principal stimuli of linear growth. Growth failure in children with chronic cholestatic jaundice may be related to decreased hepatic synthesis of IGF-I. It was hypothesized that (1) biliary obstruction would lead to growth retardation and decreased circulating IGF-I levels; and (2) surgical drainage of the obstructed biliary system would reverse these effects. To test this hypothesis, the following study of male Sprague-Dawley rats (135 g; 10 animals per group) was performed. Group I underwent common bile duct ligation (CDL); group II underwent choledochoduodenostomy 2 weeks following CDL; group III were sham-operated and fed with CDL rats; and group IV were sham-operated and fed ad libitum. Daily food intake and weekly body weight were recorded. Statistical analysis was by repeated-measures analysis of variance and individual comparisons were evaluated by Student's t test. Biliary obstruction results in decreased food intake, rate of weight gain, and IGF-I levels. A significant reduction in IGF-I levels was also noted in the pair-fed sham-operated rats (group III). Relief of obstructive jaundice by surgical drainage results in a reversal of these changes. It is concluded that the growth failure and decreased IGF-I levels associated with obstructive jaundice can be reversed by surgical drainage of the obstructed biliary system and, in part, are due to inadequate nutrition.

journal_name

J Pediatr Surg

authors

Katz S,Pescovitz OH,Grosfeld JL

doi

10.1016/0022-3468(91)90833-f

subject

Has Abstract

pub_date

1991-08-01 00:00:00

pages

900-2; discussion 903

issue

8

eissn

0022-3468

issn

1531-5037

pii

0022-3468(91)90833-F

journal_volume

26

pub_type

杂志文章
  • Mutation analysis of the motor neuron and pancreas homeobox 1 (MNX1, former HLXB9) gene in Swedish patients with Currarino syndrome.

    abstract:BACKGROUND:Currarino syndrome (CS) is a triad consisting of partial sacral agenesis, presacral mass, and anorectal malformations, typically anal stenosis but the phenotype varies. The main cause of this monogenic disorder is mutations in the motor neuron and pancreas homeobox 1 gene. We describe the clinical and geneti...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/j.jpedsurg.2011.02.039

    authors: Zu S,Winberg J,Arnberg F,Palmer G,Svensson PJ,Wester T,Nordenskjöld A

    更新日期:2011-07-01 00:00:00

  • Primary hyperparathyroidism in children.

    abstract::We present here a series of seven children with primary hyperparathyroidism caused by parathyroid adenoma. Chief cells were the primary element in six patients and water-clear cells in one patient. A brief review of the literature on primary hyperparathyroidism in children is included. Emphasis is placed on the clinic...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/s0022-3468(86)80505-x

    authors: Rapaport D,Ziv Y,Rubin M,Huminer D,Dintsman M

    更新日期:1986-05-01 00:00:00

  • Correction of congenital chordee penis by 'ventral separation and outward rotation of corpora'.

    abstract:BACKGROUND/PURPOSE:The formation of congenital chordee penis in patients with or without hypospadias is multifactorial and not completely clear. In most cases, after release of all known causes of chordee, "residual" penile curvature can persist. The authors discuss the etiopathogenetic mechanisms of congenital chordee...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1053/jpsu.2002.35006

    authors: Dessanti A,Iannuccelli M,Falchetti D,Sotgiu S,Scanu AM,Feo C

    更新日期:2002-09-01 00:00:00

  • Granular cell tumor of the biliary tree in a pediatric patient.

    abstract::Granular cell tumor of the biliary tree is a rare benign tumor that occurs most commonly in young African-American girls. Granular cell tumor rarely is included in the differential diagnosis of biliary obstruction, yet complete surgical excision is curative. The authors report a case of granular cell tumor of the bili...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1053/jpsu.2000.0350652

    authors: Reynolds EM,Tsivis PA,Long JA

    更新日期:2000-04-01 00:00:00

  • Nutritional morbidity in survivors of congenital diaphragmatic hernia.

    abstract:PURPOSE:The purpose of this report is to detail the nutritional sequelae seen in survivors of congenital diaphragmatic hernia (CDH) followed in a multidisciplinary clinic. METHODS:Data on 121 surviving CDH patients seen between 1990 and 2000 were collected. Regression analysis was used to determine the impact of facto...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1053/jpsu.2001.25746

    authors: Muratore CS,Utter S,Jaksic T,Lund DP,Wilson JM

    更新日期:2001-08-01 00:00:00

  • Cost effectiveness of the quality assurance and performance improvement project for suspected appendicitis study.

    abstract:INTRODUCTION:Appendicitis is the most common pediatric emergent surgical condition, with 77,000 American pediatric admissions costing $680 million US annually. Diagnosing appendicitis can be challenging. The prospective Quality Assurance and performance improvement project for suspected aPPEndicitis (QAPPE) study imple...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/j.jpedsurg.2020.09.006

    authors: Eamer G,Turnbull V,Robinson T,Alfraih Y,Flageole H

    更新日期:2020-09-24 00:00:00

  • Stenting for caustic strictures: esophageal replacement replaced.

    abstract:METHODS:From 1983 to 1996, 31 children with caustic esophageal strictures were seen at Bambino Gesù Children's Hospital; they were all treated conservatively except for two cases complicated by tracheoesophageal fistula. The remaining 29 patients were divided into three groups depending on the treatment, which was modi...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/s0022-3468(98)90361-x

    authors: De Peppo F,Zaccara A,Dall'Oglio L,Federici di Abriola G,Ponticelli A,Marchetti P,Lucchetti MC,Rivosecchi M

    更新日期:1998-01-01 00:00:00

  • Pericardial cysts in children: surgical or conservative approach?

    abstract::The authors present a case of an 11-year-old boy with a history of mild asthma and cough who underwent radiographic examination of the chest. The radiograph showed a round, discrete mass in the right cardiophrenic angle. The patient underwent thoracoscopic excision, and histologic examination found a unilocular, peric...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/s0022-3468(03)00285-9

    authors: Noyes BE,Weber T,Vogler C

    更新日期:2003-08-01 00:00:00

  • Hemodialysis via the Scribner shunt in childhood: a surgical evaluation.

    abstract::From 1973 to 1988, 105 children with renal failure (average age, 6.5 years; range, 5 days to 16.2 years) were treated with hemodialysis via surgically implanted Scribner shunts (n = 120). The average duration of dialysis was 16 days (range, 1 to 194 days). Twenty-three patients died during treatment or during the hosp...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/0022-3468(94)90153-8

    authors: Huber R,von Lilien T,Huber PM,Anstöss S,Schmitz-Rixen T,Erasmi H

    更新日期:1994-11-01 00:00:00

  • Complete vs partial fundoplication in children with esophageal atresia.

    abstract:PURPOSE:The purpose of the study was to compare outcomes after partial vs complete fundoplication in patients with prior esophageal atresia repair. METHODS:All patients undergoing fundoplication following esophageal atresia repair at a tertiary care pediatric hospital from 1987 to 2006 were retrospectively reviewed. A...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/j.jpedsurg.2011.02.018

    authors: Levin DN,Diamond IR,Langer JC

    更新日期:2011-05-01 00:00:00

  • Ischemia/reperfusion: a clinically relevant model of intestinal injury yielding systemic inflammation.

    abstract:BACKGROUND/PURPOSE:Multisystem organ failure (MSOF) is a major cause of morbidity and mortality in the critically ill patient. Animal models of endotoxin-induced sepsis were used to develop therapeutic regimens, which thus far have failed in clinical trials. Because multiple etiologies of MSOF affect the intestine, the...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/j.jpedsurg.2004.11.045

    authors: Stallion A,Kou TD,Latifi SQ,Miller KA,Dahms BB,Dudgeon DL,Levine AD

    更新日期:2005-03-01 00:00:00

  • Trends in pediatric adjusted shock index predict morbidity and mortality in children with severe blunt injuries.

    abstract:PURPOSE:The utility of measuring the pediatric adjusted shock index (SIPA) at admission for predicting severity of blunt injury in pediatric patients has been previously reported. However, the utility of following SIPA after admission is not well described. METHODS:The trauma registry from a level-one pediatric trauma...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/j.jpedsurg.2017.10.045

    authors: Vandewalle RJ,Peceny JK,Dolejs SC,Raymond JL,Rouse TM

    更新日期:2018-02-01 00:00:00

  • Rectal mucosectomy: a definitive approach to extensive hemangiomas of the rectum.

    abstract::Major rectal bleeding may occur in children and adults who have extensive hemangiomatous involvement of the pelvis and rectosigmoid colon, as in the Kleppel-Trenaunay syndrome (KTS). Conventional surgical techniques such as bowel resection and colostomy have often been associated with large blood loss and/or incontine...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/0022-3468(93)90235-d

    authors: Telander RL,Ahlquist D,Blaufuss MC

    更新日期:1993-03-01 00:00:00

  • Laparoscopic suture rectopexy for full-thickness anorectal prolapse in children: an effective outpatient procedure.

    abstract:BACKGROUND/PURPOSE:Our approach to full-thickness anorectal prolapse has transitioned to laparoscopic suture rectopexy (LSRP). The purpose of this study was to describe the indications, technique, and postoperative outcomes for LSRP. METHODS:Rectopexy was performed using 3 or 4 laparoscopic ports. Redundant rectum was...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/j.jpedsurg.2010.06.006

    authors: Potter DD,Bruny JL,Allshouse MJ,Narkewicz MR,Soden JS,Partrick DA

    更新日期:2010-10-01 00:00:00

  • Lung abscess: an unusual presentation of congenital tracheoesophageal fistula without atresia.

    abstract::Tracheoesophageal fistula (TEF) without atresia is rare and usually presents with symptoms from birth. In this report, a 9-year-old boy presented with productive cough of 4 month's duration and was shown to have a right lung abscess seen on chest radiograph. His parents denied earlier respiratory symptoms or illnesses...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/s0022-3468(98)90294-9

    authors: Quah BS,Indudharan R,Hashim I,Simpson H

    更新日期:1998-12-01 00:00:00

  • Locally increased concentrations of inflammatory cytokines in an experimental intraabdominal adhesion model.

    abstract:BACKGROUND:Peritoneal adhesions may cause bowel obstruction, infertility, and pain. This study investigated cytokines, proteins and growth factors thought to promote formation of adhesions in an experimental intraabdominal adhesion model. METHODS:Male Sprague-Dawley rats were subjected to laparotomy, cecal abrasion, a...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/j.jpedsurg.2014.03.010

    authors: Fredriksson F,Christofferson RH,Carlsson PO,Lilja HE

    更新日期:2014-10-01 00:00:00

  • An unusual case of monozygotic epigastric heteropagus twinning.

    abstract::Epigastric heteropagus refers to unequal and asymmetric conjoined twins in which the dependent component (parasite) is smaller and usually attached to the epigastrium of the dominant component (autosite). Epigastric heteropagus is a very rare type of conjoined twins. It is generally assumed that conjoined twins repres...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章,评审

    doi:10.1016/s0022-3468(96)90857-x

    authors: Hwang EH,Han SJ,Lee JS,Lee MK

    更新日期:1996-10-01 00:00:00

  • Do prognostic factors exist for total colonic aganglionosis with ileal involvement?

    abstract:BACKGROUND/PURPOSE:Total colonic aganglionosis with ileal involvement is estimated at 1 case in 50,000 living births. This pathology has a very variable prognosis, and patients often need long-term parenteral nutrition. The aim of this study is to define prognostic factors for this disease. METHODS:This is a retrospec...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1053/jpsu.2002.29430

    authors: Fouquet V,De Lagausie P,Faure C,Bloch J,Malbezin S,Ferkhadji L,Bauman C,Aigrain Y

    更新日期:2002-01-01 00:00:00

  • The effect of vitamin A deficiency in maternal rats on tumor formation in filial rats.

    abstract:PURPOSE:We established a vitamin A-deficient (VAD) model of pregnant rats to evaluate the effect of vitamin A deficiency in maternal rats on tumor formation in filial rats. METHODS:Ten pregnant Wistar rats were divided into 2 groups: (1) VAD group, 6 rats were given nonvitamin A diet from 2 weeks before mating till de...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/j.jpedsurg.2008.07.008

    authors: Li K,Zeng S,Gao J,Chen L,Wang Y

    更新日期:2009-03-01 00:00:00

  • Malignant benign neonatal sacrococcygeal teratoma.

    abstract::Thirty-six patients with benign neonatal sacrococcygeal teratoma (SCT) were treated in our medical center from 1972 to 1990. Mean gestational age was 38.6 +/- 3.3 weeks with a mean birth weight of 3,484.0 +/- 938.5 g. Twenty-nine patients (89%) were females. The majority of the tumors (75%) contained cystic components...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/0022-3468(93)90154-d

    authors: Bilik R,Shandling B,Pope M,Thorner P,Weitzman S,Ein SH

    更新日期:1993-09-01 00:00:00

  • Retroperitoneal necrotizing fasciitis in a 4-year-old girl.

    abstract::Necrotizing fasciitis is a rare but serious condition with a poor prognosis both in adults and in children. Retroperitoneal localization is mostly associated with fatal outcome. Early diagnosis, extensive and repeated surgical debridement, and use of antibiotics are necessary. Herein the authors report on a 4-year-old...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/s0022-3468(98)90219-6

    authors: Paya K,Hayek BF,Rebhandl W,Pollak A,Horcher E

    更新日期:1998-05-01 00:00:00

  • Prostatorectal fistula associated with tubular colorectal duplication.

    abstract::Tubular colonic duplications are exceedingly rare. The authors present an unusual case of a boy with a persistent prostatorectal fistula resulting from a tubular colorectal duplication. The current case is unique for 2 reasons: (1) the presence of a fistula without any concomitant genitourinary anomalies and (2) the e...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/s0022-3468(99)90126-4

    authors: Kokoska ER,Steinhardt GF,Tomita SS,Weber TR

    更新日期:1999-10-01 00:00:00

  • Bleeding gastric ulcer in a newborn infant diagnosed by transumbilical aortography.

    abstract::Transumbilical aortography has been utilized for the first time to diagnose the cause of massive upper gastrointestinal hemorrhage in a newborn infant. We consider it a safe and accurate method in cases that meet the following criteria: massive hemorrhage uncontrollable by blood transfusions and supportive medical the...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/0022-3468(77)90205-6

    authors: Fliegel CP,Herzog B,Signer E,Nars P

    更新日期:1977-08-01 00:00:00

  • Perinatal management of congenital diaphragmatic hernia: when and how should babies be delivered? Results from the Canadian Pediatric Surgery Network.

    abstract:PURPOSE:A prenatal diagnosis of congenital diaphragmatic hernia (CDH) enables therapeutic decision making during the intrapartum period. This study seeks to identify the gestational age and delivery mode associated with optimal outcomes. PATIENTS AND METHODS:A national data set was used to study CDH babies born betwee...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/j.jpedsurg.2010.08.026

    authors: Safavi A,Lin Y,Skarsgard ED,Canadian Pediatric Surgery Network.

    更新日期:2010-12-01 00:00:00

  • Esophageal atresia and tracheo-esophageal fistula in a patient with Digeorge syndrome.

    abstract::DiGeorge Syndrome (DGS) is a congenital disorder that affects the thymus, parathyroid glands, and heart and brain. Thymus involvement in DGS may vary between absence/hypoplasia of thymus to various forms of reduced T cell function. TBX1 deficiency causes a number of distinct vascular and heart defects, suggesting mult...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/s0022-3468(03)00295-1

    authors: Kilic SS,Gurpinar A,Yakut T,Egeli U,Dogruyol H

    更新日期:2003-08-01 00:00:00

  • Long-term orthopedic outcomes in patients with epispadias and bladder exstrophy.

    abstract:BACKGROUND/PURPOSE:The aim of the study was to explore long-term orthopedic outcomes in patients with epispadias and bladder exstrophy (BE). METHODS:Sixty-three adult patients with epispadias or BE were mailed the Modified Nordic Musculoskeletal Questionnaire, of which 33 (52%) responded. The patients were reviewed fo...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/j.jpedsurg.2012.04.023

    authors: Suominen JS,Helenius I,Taskinen S

    更新日期:2012-10-01 00:00:00

  • First reported successful management of Serratia marcescens bacteremia after open heart surgery in a child.

    abstract::A 7 and one-half yr-old girl developed bacteremia from S. marcescens following debanding of the pulmonary artery and closure of multiple ventricular septal defects with a Dacron patch and multiple Teflon pledgets. The site of entry was probably a radial arterial catheter left in place for 8 days. Infection was eradica...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章,评审

    doi:10.1016/s0022-3468(75)80098-4

    authors: Saxena NC,Friedman S,Plotkin S,Edmunds LH Jr

    更新日期:1975-12-01 00:00:00

  • Posterior plication of the rectum for rectal prolapse in children.

    abstract::Fourteen patients with rectal prolapse (age range, 1 to 12 years) underwent posterior plication of the rectum for rectal prolapse. The procedure consisted of (1) natal cleft incision, (2) midline separation of the levator muscle, (3) dissection of two thirds of the circumference of the rectum, (4) plication of the pos...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/0022-3468(95)90692-4

    authors: Tsugawa C,Matsumoto Y,Nishijima E,Muraji T,Higashimoto Y

    更新日期:1995-05-01 00:00:00

  • Wide gap esophageal atresia: a new method to elongate the upper pouch.

    abstract::A new surgical method is presented for overbridging wide gap esophageal atresia. The method is based on the fact that the atretic upper pouch has an excellent longitudinal blood supply, and is two to three times wider than the lower pouch. Muco-muscular flap is created, which is anastomosed to the lower esophagus. ...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/s0022-3468(89)80587-1

    authors: Bar-Maor JA,Shoshany G,Sweed Y

    更新日期:1989-09-01 00:00:00

  • Understanding non-accidental trauma in the United States: A national trauma databank study.

    abstract:BACKGROUND:The purpose of this study is to characterize the epidemiology, injury patterns, outcomes and trends of non-accidental trauma (NAT) in the United States using a large national database. METHODS:Children <15 years presenting after NAT were identified in the 2007-2014 National Trauma Databank research datasets...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/j.jpedsurg.2019.03.024

    authors: Rosenfeld EH,Johnson B,Wesson DE,Shah SR,Vogel AM,Naik-Mathuria B

    更新日期:2020-04-01 00:00:00