Renal parenchymal malacoplakia: a different stage of xanthogranulomatous pyelonephritis?

Abstract:

:Malacoplakia is a rare inflammatory condition characterized by demonstrative Michaelis-Gutmann bodies, which are foamy histiocytes with distinctive basophilic inclusions. Malacoplakia is caused by the inadequate elimination of bacteria by macrophages or monocytes as a result of defective phagocytic activity. Xanthogranulomatous pyelonephritis is characterized by the destruction of renal parenchyma and its replacement by solid sheets of foamy lipid-laden macrophages. Prolonged infection of the kidney, which is frequently caused by an obstruction of the urinary tract, is the pathologic mechanism of that condition. We present a 6-year-old patient with a poorly functioning kidney who had a prolonged recurrent urinary tract infection. The results of histologic analysis revealed an inflammatory infiltration consisting predominantly of foamy and epithelioid histiocytes that contained round intracytoplasmic concretions characteristic of Michaelis-Gutmann bodies. We suggest that malacoplakia might be a stage of xanthogranulomatous pyelonephritis.

journal_name

J Pediatr Surg

authors

Yiğiter M,Ilgici D,Celik M,Arda IS,Hiçsönmez A

doi

10.1016/j.jpedsurg.2007.05.005

subject

Has Abstract

pub_date

2007-07-01 00:00:00

pages

E35-8

issue

7

eissn

0022-3468

issn

1531-5037

pii

S0022-3468(07)00343-0

journal_volume

42

pub_type

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