Effects of maturation and aging on calmodulin and calmodulin-regulated enzymes in various regions of mouse brain.

abstract：:We examined physiological changes in CD5(+) B lymphocytes in mice associated with aging (from 1 or 5 to 50 weeks of age). The most predominant populations of lymphocytes among these mice were mainly CD5(-) B cells in the spleen and peritoneal cavity, and T cells in the thymus. However, in the spleen, CD5(+) B cells in...

journal_title：Mechanisms of ageing and development

authors： Watanabe K,Watanabe M,Maruoka H,Amino N,Iwatani Y

更新日期：2001-10-01 00:00:00

abstract：:Mitochondrial DNA (mtDNA) was isolated from liver mitochondria of rats between 2 and 24 months of age. The mtDNA was purified by cesium chloride--ethidium bromide isopycnic density gradient centrifugation. In the gradients, in addition to the two expected bands of ethidium--DNA complex, there was observed a third, mor...

journal_title：Mechanisms of ageing and development

authors： Murray MA,Balcavage WX

更新日期：1982-11-01 00:00:00

abstract：:A mutant of rad-8, originally isolated on the basis of its hypersensitivity to ultraviolet radiation, is also hypersensitive to oxygen and methyl viologen, a superoxide-anion generator. Oxygen also retarded development and reduced fecundity in a concentration-dependent fashion in rad-8 but not in wild type. In additio...

journal_title：Mechanisms of ageing and development

authors： Ishi N,Suzuki N,Hartman PS,Suzuki K

更新日期：1993-05-01 00:00:00

abstract：:An increasing body of data is progressively indicating that the comprehension of the epigenetic landscape, actively integrated with the genetic elements, is crucial to delineate the molecular basis of the inter-individual complexity of ageing process. Indeed, it has emerged that DNA methylation changes occur during ag...

journal_title：Mechanisms of ageing and development

authors： Bacalini MG,D'Aquila P,Marasco E,Nardini C,Montesanto A,Franceschi C,Passarino G,Garagnani P,Bellizzi D

更新日期：2017-07-01 00:00:00

abstract：:To investigate age-related changes in gene expression in WI-38 cells, we isolated RNA from young and senescent, quiescent cultures and made subtracted cDNA libraries. Density-arrested cells were incubated in serum-free MCDB-104 for 3 days. RNA was then isolated and subtracted cDNA libraries were made in the phagemid v...

journal_title：Mechanisms of ageing and development

authors： Doggett DL,Rotenberg MO,Pignolo RJ,Phillips PD,Cristofalo VJ

更新日期：1992-09-01 00:00:00

abstract：:Active vitamin D drugs are used for the treatment of osteoporosis in a number of countries, including Japan. However, their use is controversial. Here, we briefly discuss two issues that are important for understanding the role of active vitamin D (rather than plain vitamin D) in the treatment of osteoporosis: (1) whe...

journal_title：Mechanisms of ageing and development

authors： Ikeda K,Ogata E

更新日期：2000-07-31 00:00:00

abstract：:Social isolation (SI) is a major health risk in older people leading to cognitive decline. This study examined how SI and age influence performance in the novel object recognition (NOR) and elevated plus maze (EPM) tasks in C57BL/6 mice aged 3 or 24 months. Mice were group-housed (groups of 2-3) or isolated for 2 week...

journal_title：Mechanisms of ageing and development

authors： Panossian A,Cave MW,Patel BA,Brooks EL,Flint MS,Yeoman MS

更新日期：2020-10-01 00:00:00

abstract：:The decline in the lymphoproliferative response to mitogenic stimuli shows marked heterogeneity in elderly individuals. Adequate nutriture is required for optimal immune function, yet nutritional status may be compromised in the elderly. To address whether this variation in the proliferative response of elderly indivi...

journal_title：Mechanisms of ageing and development

authors： Gardner EM,Bernstein ED,Dorfman M,Abrutyn E,Murasko DM

更新日期：1997-03-01 00:00:00

abstract：:Ceramide mediates the effects of several agonists leading to differentiation, apoptosis or senescence. We previously showed that ceramide becomes elevated in senescent fibroblasts. In the present study, senescent cultures of Wi-38 fibroblasts and human umbilical-vein endothelial cells were compared to low-passage cult...

journal_title：Mechanisms of ageing and development

authors： Venable ME,Webb-Froehlich LM,Sloan EF,Thomley JE

更新日期：2006-05-01 00:00:00

abstract：:Nitric oxide synthase (NOS) activity was enhanced in human umbilical vein endothelial cells (HUVECs) by the combined stimulation with IFN-gamma plus IL-1beta, TNF-alpha and LPS which was accompanied by cell death. DNA analysis of the NOS induced dead HUVECs showed that internucleosomal DNA fragmentation had occurred, ...

journal_title：Mechanisms of ageing and development

authors： Sato I,Kaji K,Murota S

更新日期：1995-06-30 00:00:00

abstract：:The health status of the oldest old, the fastest increasing population segment worldwide, progressively becomes more heterogeneous, and this peculiarity represents a major obstacle to their classification. We compared the effectiveness of four previously proposed criteria (Franceschi et al., 2000; Evert et al., 2003; ...

journal_title：Mechanisms of ageing and development

authors： Cevenini E,Cotichini R,Stazi MA,Toccaceli V,Scurti M,Mari V,Berardelli M,Passarino G,Jeune B,Franceschi C,GEHA Project Consortium.

更新日期：2013-11-01 00:00:00

abstract：:Age-related and ambient temperature-related changes in motor activity, body temperature, body weight (b.w.), and food consumption were studied in the long-lived Peromyscus leucopus mouse at environmental temperatures of 29 and 21 degrees C. Major changes in physiological performance were observed between the young (6 ...

journal_title：Mechanisms of ageing and development

authors： Duffy PH,Feuers RJ,Pipkin JL,Turturro A,Hart RW

更新日期：1997-04-01 00:00:00

abstract：:In this paper, we approach the problem of attempting to understand senescence by understanding the complexity and hierarchical structure of mammalian organisms. To do this, we make use of some concepts from abstract relational biology; in particular, graph theory. We subsequently utilize these concepts to develop the ...

journal_title：Mechanisms of ageing and development

authors： Witten M

更新日期：1984-10-31 00:00:00

abstract：:It has been previously well documented that partial pressure of oxygen (PO2) and weight-specific rate of O2 consumption in chick embryo (Gallus gallus domesticus) transiently increase midway through the 21-day in ovo incubation period. The present study found that these oxidative changes were paralleled by the concent...

journal_title：Mechanisms of ageing and development

authors： Wilson JX,Lui EM,Del Maestro RF

更新日期：1992-08-01 00:00:00

abstract：:The impairment of brown adipose tissue (BAT) thermogenic activity with aging has been well documented. The current study investigated the effect of swimming training on BAT activity in 2-month-old (young) and 26-month-old (old) male mice. The trained mice underwent a 6-week swimming program (1 h/day, 5 days/week) in w...

journal_title：Mechanisms of ageing and development

authors： Oh-ishi S,Kizaki T,Toshinai K,Haga S,Fukuda K,Nagata N,Ohno H

更新日期：1996-08-15 00:00:00

abstract：:In this paper, some of the key findings of the last decade will briefly be surveyed and, where possible, be related to two separate computer simulation models which have been designed to determine the validity of certain widely accepted dogmas and to define the limits and restrictions imposed by attrition of or ambigu...

journal_title：Mechanisms of ageing and development

authors： Strehler BL,Freeman MR

更新日期：1980-09-01 00:00:00

abstract：:The intertwining between epilepsy, sleep disorders and beta amyloid pathology has been progressively highlighted, as early identification and stratification of patients at high risk of cognitive decline is the need of the hour. Modification of the sleep-wake activity, such as sleep impairment or excessive daytime slee...

journal_title：Mechanisms of ageing and development

authors： Liguori C,Spanetta M,Romoli M,Placidi F,Nardi Cesarini E,Mercuri NB,Costa C

更新日期：2021-01-11 00:00:00

abstract：:There is an alteration of the immune response in aging that leads to the increased incidence of infections, cancers and autoimmune disorders. The aim of the present study was to investigate whether there exists changes in signal transduction under the IL-2 receptor stimulation and the role of plasma membrane cholester...

journal_title：Mechanisms of ageing and development

authors： Fülöp T Jr,Douziech N,Goulet AC,Desgeorges S,Linteau A,Lacombe G,Dupuis G

更新日期：2001-09-15 00:00:00

abstract：:Specific T-cell cytotoxic responses to allogeneic and hapten-modified syngeneic cells decrease with age. In order to determine the causes of these reduced T-cell cytotoxic responses, spleen cells from individual young and senescent C57BL/6J female mice were mixed in various proportions in culture with either X-irradia...

journal_title：Mechanisms of ageing and development

authors： Zharhary D,Segev Y,Gershon HE

更新日期：1984-04-01 00:00:00

abstract：:The present work explores the application of information theoretical measures, such as entropy and normalized mutual information, for research of biomarkers of aging. The use of information theory affords unique methodological advantages for the study of aging processes, as it allows evaluating non-linear relations be...

journal_title：Mechanisms of ageing and development

authors： Blokh D,Stambler I

更新日期：2017-04-01 00:00:00

abstract：:Epidermal mass of the skin of Balb/c female mice of 2, 6, 12, and 20 months of age was determined by measuring epidermal wet weight, RNA, DNA, and protein per unit area (100 cm2) of skin. Epidermal wet weight is significantly decreased in 20-month-old mice compared to 2-month-old mice. This represents a real decrease ...

journal_title：Mechanisms of ageing and development

authors： Argyris TS

更新日期：1983-07-01 00:00:00

abstract：INTRODUCTION:Our objective was to study the impact of an identical additional stress on male and female mortality with a quasi-experimental study design, using natural variations in summer mortality, including the massive heat wave that struck Europe in 2003. MATERIAL AND METHODS:The summer daily mortality rates of th...

journal_title：Mechanisms of ageing and development

authors： Robine JM,Michel JP,Herrmann FR

更新日期：2012-06-01 00:00:00

abstract：:Age-related variations in the stromal cell population of human bone marrow were studied by means of a cloning assay. It was found that these cells are heterogeneous both in division capacity and in morphology. Fibroblast-like progenitor cells could be distinguished from epithelial-like cells, having only a very limite...

journal_title：Mechanisms of ageing and development

authors： Mets T,Verdonk G

更新日期：1981-01-01 00:00:00

abstract：:Extrachromosomal circular DNA complexes from peripheral blood lymphocytes from inbred mice of accelerated senescence, were detected by mica-press-adsorption method. In senescence-resistant series (SAM-R), polydisperse circular DNAs were observed at 7 weeks of age and a restricted size class of small circular forms of ...

journal_title：Mechanisms of ageing and development

authors： Yamagishi H,Kunisada T,Takeda T

更新日期：1985-01-01 00:00:00

abstract：:In this study, we showed that in flies kept for 2 weeks at 1 (terrestrial gravity), 3 or 5 x g (hypergravity, HG) before transfer to 1 x g, resistance to heat remained higher in HG flies for several weeks after the transfer. The measurement of heat shock protein 70 (hsp70) indicated no induction of the protein in HG, ...

journal_title：Mechanisms of ageing and development

authors： Minois N,Guinaudy MJ,Payre F,Le Bourg E

更新日期：1999-06-01 00:00:00

abstract：:The age-related changes in the distribution of enkephalin-immunoreactive (ENK-IR) nerve fibers in relation to the principal neurons were studied in 23 human sympathetic ganglia from patients aged between 22 and 98 years. There were no age-related changes in the diameter of nerve cells and the packing density of the ne...

journal_title：Mechanisms of ageing and development

authors： Järvi R,Helen P,Pelto-Huikko M,Rapoport SI,Hervonen A

更新日期：1988-08-01 00:00:00

abstract：:Different theories of ageing exist. Oxidative stress by generating neo-antigens and affecting cellular communications may precipitate immune disregulation, and both may concur in the whole ageing process. In the present study, we have analysed the effect of dietary high doses of vitamin E, a free radical scavenger, on...

journal_title：Mechanisms of ageing and development

authors： Brohée D,Nève P

更新日期：1994-10-20 00:00:00

abstract：:Age-specific mortality from carcinoma of the prostate was analyzed by drawing a line between the value at age 52 years and that at age 87. Slope of the line was relatively constant for the pooled years 1962-1966, 1967-1971 and 1972-1976 (maximum variation from the mean of 4.5%). However, the slope was 17.7% greater fo...

journal_title：Mechanisms of ageing and development

authors： Clive JM,Spencer RP

更新日期：1995-08-31 00:00:00

abstract：:The progression of many neurodegenerative diseases is assumed to be caused by misfolding of specific characteristic diseases related proteins, resulting in aggregation and fibril formation of these proteins. Protein misfolding associated age related diseases, although different in disease manifestations, share strikin...

journal_title：Mechanisms of ageing and development

authors： Eftekharzadeh B,Hyman BT,Wegmann S

更新日期：2016-06-01 00:00:00

abstract：:The decline in phytohemagglutinin (PHA) responsiveness of spleen cells from aged mice was studied in an effort to determine the nature of the depressed PHA reactivity. The reduced response of DNA synthesis (thymidine incorporation) to PHA stimulation could not be attributed to a decreased viability of spleen lymphocyt...

journal_title：Mechanisms of ageing and development

authors： Hung CY,Perkins EH,Yang WK

更新日期：1975-01-01 00:00:00