HSP70 induction may explain the long-lasting resistance to heat of Drosophila melanogaster having lived in hypergravity.

abstract：:Considerable evidence points to an accumulation of somatic mutations in older cells and organisms but the causal role of mutations in the ageing process is still unclear. In addition to demonstrating that mutations accumulate, it is important to address the question of whether they do so at a sufficient rate and with ...

journal_title：Mechanisms of ageing and development

authors： Kirkwood TB,Proctor CJ

更新日期：2003-01-01 00:00:00

abstract：:The development and aging of the nucleolus and nucleus in layer V pyramidal cells in the hamster cerebrum were studied by light and electron microscopy. The nucleoli appeared in the newborn as occasional fibrillar masses adjacent to peripherally placed bodies of chromatin. By maturity, a single, generally central, nuc...

journal_title：Mechanisms of ageing and development

authors： Buschmann MB,LaVelle A

更新日期：1981-04-01 00:00:00

abstract：:Analysis was made of the cellular basis of decline in the antibody immune response with advancing age. Employing the cell transfer system, it was found that spleen cells of aged mice have a limited capacity to react to SRBC when transferred into young irradiated recipients. Partial reconstitution was achieved when thy...

journal_title：Mechanisms of ageing and development

authors： Friedman D,Globerson A

更新日期：1978-04-01 00:00:00

abstract：:We investigated the Coenzyme Q (CoQ) content of different mitochondrial fractions [free mitochondria (FM), synaptic heavy (HM) and light mitochondria (LM)] from three brain areas (cortex, striatum, hippocampus) of rats at different ages. In rats from 2 to 26 months of age, we observed only small differences in total C...

journal_title：Mechanisms of ageing and development

authors： Battino M,Gorini A,Villa RF,Genova ML,Bovina C,Sassi S,Littarru GP,Lenaz G

更新日期：1995-03-17 00:00:00

abstract：:The effect of the oral administration of 0.150 mg/m2 clonidine on the plasma level of human growth hormone (hGH) was studied in 53 adults (25 males and 28 females) aged from 28 to 68 years, of which 15 were healthy volunteers and 38 were hypertensive. Both the normal and hypertensive subjects of both sexes showed an a...

journal_title：Mechanisms of ageing and development

authors： Gil-Ad I,Gurewitz R,Marcovici O,Rosenfeld J,Laron Z

更新日期：1984-09-01 00:00:00

abstract：:Social isolation (SI) is a major health risk in older people leading to cognitive decline. This study examined how SI and age influence performance in the novel object recognition (NOR) and elevated plus maze (EPM) tasks in C57BL/6 mice aged 3 or 24 months. Mice were group-housed (groups of 2-3) or isolated for 2 week...

journal_title：Mechanisms of ageing and development

authors： Panossian A,Cave MW,Patel BA,Brooks EL,Flint MS,Yeoman MS

更新日期：2020-10-01 00:00:00

abstract：:In yeast, increasing the copy number of the nicotinamide adenine dinucleotide (NAD)-dependent deacetylase Sir2 extends lifespan, which can be inhibited by nicotinamide (Nam), the end-product of Sir2-mediated NAD-breakdown. Furthermore, the yeast pyrazinamidase/nicotinamidase PNC-1 can extend yeast lifespan by converti...

journal_title：Mechanisms of ageing and development

authors： van der Horst A,Schavemaker JM,Pellis-van Berkel W,Burgering BM

更新日期：2007-04-01 00:00:00

abstract：:In the present study, a number of physiological and behavioral measures that are related to metabolism were continuously monitored in 19-month-old male Fischer 344 rats that were fed ad libitum or fed a caloric restricted diet. Caloric restricted rats ate fewer meals but consumed more food during each meal and spent m...

journal_title：Mechanisms of ageing and development

authors： Duffy PH,Feuers RJ,Leakey JA,Nakamura K,Turturro A,Hart RW

更新日期：1989-05-01 00:00:00

abstract：:The incidence of chronic diseases such as cardiovascular diseases is lower in Mediterranean Southern Europe than Northern Europe. This may be due to a lower level of oxidative stress and a higher antioxidant status in people living around the Mediterranean Sea. Oxidative stress may influence the rate of shortening of ...

journal_title：Mechanisms of ageing and development

authors： de Vos-Houben JM,Ottenheim NR,Kafatos A,Buijsse B,Hageman GJ,Kromhout D,Giltay EJ

更新日期：2012-06-01 00:00:00

abstract：:Normal diploid Syrian hamster dermal mesenchymal cell strains, regardless of the age of the tissue of origin, exhibit in vitro cellular senescence. The frequency of spontaneous escape from senescence and conversion to a permanent cell line is less than 5% among replicate flasks. The overall pattern of senescence of ce...

journal_title：Mechanisms of ageing and development

authors： Bruce SA,Deamond SF,Ts'o PO

更新日期：1986-04-01 00:00:00

abstract：:Formalinized Mycoplasma pulmonis was used to immunize 3 different age groups of Fischer 344 rats. A specific antibody to this antigen was detected in both saliva and lung lavage fluids and differences were noted in the elicitation of secretory antibody between the different ages of the animals. Few statistical differe...

journal_title：Mechanisms of ageing and development

authors： Steffen MJ,Ebersole JL

更新日期：1992-11-01 00:00:00

abstract：:Age-related changes in blood-brain barrier permeability to macromolecules were investigated during electrically induced seizures. Evans-blue was used as the barrier tracer. There was no change in the permeability of the blood brain barrier associated with aging in the rats. However, the extravasation of Evans-blue alb...

journal_title：Mechanisms of ageing and development

authors： Oztas B,Kaya M,Camurcu S

更新日期：1990-02-01 00:00:00

abstract：:Pancreatic islet B cells from Sprague-Dawley and Fisher 344 rats aged 3-27 months were separated from A and D cells by centrifugation over a linear percoll density gradient, and incubated in vitro with various concentrations of glucose and somatostatin. Elevation of glucose concentration in the incubation medium from ...

journal_title：Mechanisms of ageing and development

authors： Magal E,Chaudhuri M,Adelman RC

更新日期：1986-01-01 00:00:00

abstract：:Prostaglandin (PG) synthesis by human embryo lung fibroblasts in culture was determined with increasing population doubling. These cultures synthesized PGE2, PGF2 alpha, PGI2 (prostacyclin) and TXA2 (thromboxane A2) in response to fetal bovine serum or ascorbic acid. Changes in prostaglandin synthesis by these cells d...

journal_title：Mechanisms of ageing and development

authors： Polgar P,Taylor L

更新日期：1980-04-01 00:00:00

abstract：:The purpose of the present study was to investigate the effect of aging on silica-induced lung toxicity. In young animals silica induced a significant increase in bronchoalveolar lavage tumor necrosis factor-alpha (TNF), lactate dehydrogenase as well as in cell numbers, which correlate with increased collagen depositi...

journal_title：Mechanisms of ageing and development

authors： Corsini E,Giani A,Peano S,Marinovich M,Galli CL

更新日期：2004-02-01 00:00:00

abstract：:Relationships between nutrition and longevity are of growing interest. Here we analysed the influences of dietary restriction on the survival of Drosophila exposed to atmospheric oxygen or to chronic hypoxia. Dietary restriction was achieved by food dilution, by sucrose restriction or by yeast restriction. Sucrose and...

journal_title：Mechanisms of ageing and development

authors： Vigne P,Frelin C

更新日期：2007-05-01 00:00:00

abstract：:The ascidian Ciona intestinalis has a short life span and powerful regeneration capacities. The regeneration of the oral siphon (OS) involves wound healing, blastema formation, cell proliferation, and replacement of 8 oral pigment organs (OPO), the latter via differentiation and migration of stem/precursor cells from ...

journal_title：Mechanisms of ageing and development

authors： Jeffery WR

更新日期：2012-09-01 00:00:00

abstract：:The present work explores the application of information theoretical measures, such as entropy and normalized mutual information, for research of biomarkers of aging. The use of information theory affords unique methodological advantages for the study of aging processes, as it allows evaluating non-linear relations be...

journal_title：Mechanisms of ageing and development

authors： Blokh D,Stambler I

更新日期：2017-04-01 00:00:00

abstract：:The combined grafting of young bone marrow and newborn thymus performed in old mice was effective in restoring the impaired immune functions, but the same treatment performed in middle-aged adult mice had no effect on the life span of C3H/MTV female mice. Sequential multiple newborn thymus graftings starting at young ...

journal_title：Mechanisms of ageing and development

authors： Hirokawa K,Utsuyama M

更新日期：1989-07-01 00:00:00

abstract：:A quantitative ultrastructural study of the posterior pituitary was undertaken. The posterior pituitary is the storage of the hormones vasopressin and oxytocin. Female C57BL/Icrfat mice which were under conditions of normal hydration were sampled at 8 and 32 months of age. There was a slight age-related decline in the...

journal_title：Mechanisms of ageing and development

authors： Wilkinson A,Davies I

更新日期：1981-02-01 00:00:00

abstract：:The intralobular distribution of three lysosomal enzymes, acid phosphatase, N-acetyl-beta-D-glucosaminidase, and beta-D-glucuronidase, was investigated in hepatocytes of 3-, 12-, 24-, and 36-month-old rats. The distribution pattern changed with age. In young rats, the activity was higher in the peripheral area than in...

journal_title：Mechanisms of ageing and development

authors： van Manen R,de Priester W,Knook DL

更新日期：1983-06-01 00:00:00

abstract：:Motor neurons and ventral root motor fibres innervating extensor digitorum longus (EDL) muscle in rats of 0.5-3.5 months of age were studied by HRP-retrograde labelling and in vivo muscle tension recording, respectively. EDL nucleus size increased with age but motor neurons number and size did not change. Twitch and t...

journal_title：Mechanisms of ageing and development

authors： Cuppini R,Ambrogini P

更新日期：1996-12-20 00:00:00

abstract：:Food intake, body weight and serum LH, FSH, progesterone and oestradiol-17 beta were monitored from weaning to puberty in fully fed females housed in groups of four or individually and in females individually housed and dietary restricted. Restriction of food intake from weaning delayed the onset of puberty (34-39 day...

journal_title：Mechanisms of ageing and development

authors： Holehan AM,Merry BJ

更新日期：1985-11-01 00:00:00

abstract：:The age-dependent drop in mixed lymphocyte reactivity and responsiveness to concanavalin A of lymph node and spleen cells of C57Bl/6J female mice were studied. The relative decrease in mixed lymphocyte reactivity was shown to be the same whether mounted against H-2 or Mls incompatibile stimulator cells. The time of pe...

journal_title：Mechanisms of ageing and development

authors： Gershon H,Merhav S,Abraham C

更新日期：1979-01-01 00:00:00

abstract：:Elastase and lipid levels of the plasmas of subjects and of those who have suffered a stroke have been measured, and it has been shown that the normal age related fall in elastase content is mirrored more closely by the fall in high density lipoprotein cholesterol than by changes in total cholesterol. After a stroke a...

journal_title：Mechanisms of ageing and development

authors： Hall DA,Elridi SS,Zajac A,Middleton RS

更新日期：1980-11-01 00:00:00

abstract：:There is currently of a great interest investigating the role of nutrition in the prevention of age-associated disorders. The present study aimed to evaluate, on a particular strain of mice, the efficacy of alternate-day fasting on the mitochondrial production of free radical species and on the incidence of a specific...

journal_title：Mechanisms of ageing and development

authors： Descamps O,Riondel J,Ducros V,Roussel AM

更新日期：2005-11-01 00:00:00

abstract：:DNA synthesis is a remarkably vulnerable phase in the cell cycle. In addition to introduction of errors during semi-conservative replication, the inherently labile structure of the replication fork, as well as numerous pitfalls encountered in the course of fork progression, make the normally stable double stranded mol...

journal_title：Mechanisms of ageing and development

authors： Ruzankina Y,Asare A,Brown EJ

更新日期：2008-07-01 00:00:00

abstract：:In the present work, we investigated whether IGF-1 regulates the transcription of the genes encoding the L-type Ca2+ channel (DHPR) channel and RyR1 in young adult and senescent mice. To this end, a transgenic mouse model overexpressing IGF-1 exclusively in skeletal muscle (S1S2) was studied at different ages and the ...

journal_title：Mechanisms of ageing and development

authors： Zheng Z,Messi ML,Delbono O

更新日期：2001-04-15 00:00:00

abstract：:Iron deficiency anaemia is prevalent in older age, particularly after the age of 80. Serum ferritin concentrations also decline, although there is no evidence to suggest that changes in iron stores are an inevitable consequence of ageing. Chronic inflammation is a common condition in older people, making the measureme...

journal_title：Mechanisms of ageing and development

authors： Fairweather-Tait SJ,Wawer AA,Gillings R,Jennings A,Myint PK

更新日期：2014-03-01 00:00:00

abstract：:Changes in the T cell pool caused by CMV infection have been proposed to contribute to immunosenescence, but it has been postulated that CMV can also have some beneficial effects in young individuals improving the immune response to other pathogens. T cells expressing CD56 (NKT-like cells) are cytotoxic effector cells...

journal_title：Mechanisms of ageing and development

authors： Hassouneh F,Campos C,López-Sejas N,Alonso C,Tarazona R,Solana R,Pera A

更新日期：2016-09-01 00:00:00