Abstract：
PURPOSE:To investigate the rate of progressive visual field (VF) loss and associated factors for structural or functional progression in preperimetric open-angle glaucoma (OAG). DESIGN:Longitudinal, observational study. METHODS:We included 127 eyes of 127 preperimetric OAG patients who were treated with topical medication and followed for more than 5 years. All patients underwent stereo optic disc photography, red-free retinal nerve fiber layer (RNFL) photography, frequency doubling technology perimetry, and standard automated perimetry (SAP). Progression was defined as a structural (glaucomatous change confirmed by stereo optic disc and red-free RNFL photography) or functional (new glaucomatous defect on SAP) deterioration. The progression rate of SAP mean deviation (dB/year) and factors associated with progression were evaluated. RESULTS:Glaucoma progression was detected in 72 of 127 eyes (56.7%). Mean rate of VF progression was -0.39 ± 0.64 dB/year in all patients; -0.66 ± 0.60 dB/year in progressors and -0.03 ± 0.24 dB/year in nonprogressors. A multivariate Cox proportional hazard model revealed that optic disc hemorrhage (hazard ratio [HR] = 1.718, P = .031) and the percentage reduction in intraocular pressure (IOP; HR = 0.964, P = .002) were significantly associated with disease progression. Patients with disc hemorrhage had a greater cumulative probability of progression than those without disc hemorrhage (P = .014 by log-rank test). CONCLUSIONS:Our results support the importance of lowering IOP, even at the preperimetric stage. Preperimetric glaucoma patients with disc hemorrhage and insufficient IOP control should be carefully monitored for greater risk of progression.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Kim KE,Jeoung JW,Kim DM,Ahn SJ,Park KH,Kim SHdoi
10.1016/j.ajo.2014.10.010subject
Has Abstractpub_date
2015-01-01 00:00:00pages
160-8.e1-2issue
1eissn
0002-9394issn
1879-1891pii
S0002-9394(14)00658-8journal_volume
159pub_type
杂志文章abstract：:In a postmortem study of 57 diabetic patients, 19 of 23 patients with blood glucose levels greater than 200 mg/100 ml in the 72-hour period before death showed the characteristic histologic findings of "lacy" vacuolation of the iris pigment epithelium as well as vacuolation of the renal tubules (Armanni-Ebstein nephro...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：1975-05-01 00:00:00
abstract：:Amyloid fibrils occurring in primary and myeloma-associated (AL), secondary (AA), and certain neuropathic hereditary forms of systemic amyloidosis can be distinguished biochemically or immunohistologically as being composed of immunoglobulin light chain, protein AA, or prealbumin respectively. All types of systemic an...
journal_title：American journal of ophthalmology
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更新日期：1984-08-15 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2002-08-01 00:00:00
abstract：PURPOSE:To describe a case of Langerhans cell histiocytosis (LCH) that involved the anterior uveal tract. DESIGN:Interventional case report. METHODS:A retrospective review was conducted on a patient with iris nodules and anterior uveitis in the setting of LCH. Visual acuity and clinical findings that were noted on sl...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2005-12-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：1975-06-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：1980-08-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2020-10-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2006-06-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2016-09-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章,多中心研究
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更新日期：2015-07-01 00:00:00
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journal_title：American journal of ophthalmology
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更新日期：2000-10-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2000-11-01 00:00:00
abstract：PURPOSE:To determine the frequency of ocular adverse effects associated with vemurafenib (PLX4032) treatment for metastatic cutaneous melanoma. DESIGN:Retrospective review of the clinical study reports from the clinical pharmacology, phase 1, phase 2, and phase 3 trials of vemurafenib. METHODS:The vemurafenib clinica...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,多中心研究
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更新日期：2014-10-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)76936-3
更新日期：1990-07-15 00:00:00
abstract：:A 14-year-old boy was stabbed above the left eye and had subsequent loss of both retinal and choroidal perfusion to the posterior segment. Ophthalmoscopic examination ten days after the injury disclosed intense nerve fiber layer edema, most prominent in the posterior pole, and absence of a cherry-red spot. Intravenous...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(79)90666-4
更新日期：1979-10-01 00:00:00
abstract：:A simple makeshift retinoscopy rack consists of various trial lenses placed into the slots of a nonfrosted, 35-mm slide viewing sheet. It is useful in determining the patient's refractive error at the bedside and in the operating room. ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(80)90242-1
更新日期：1980-01-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)75575-8
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journal_title：American journal of ophthalmology
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更新日期：2007-12-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章,多中心研究,随机对照试验
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更新日期：2014-09-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2018-08-01 00:00:00
abstract：PURPOSE:To elucidate the origin of the abnormal fundus reflex in Oguchi disease. METHODS:The ocular fundus of a 63-year-old woman who showed a homozygous arrestin 1147delA mutation was observed by scanning laser ophthalmoscopy with the use of an argon blue laser (wavelength, 488 nm), a helium-neon laser (633 nm), and ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2000-09-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2015-05-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2020-02-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(02)01791-9
更新日期：2002-12-01 00:00:00
abstract：:Nerve fiber counts of 16 normal human optic nerves from subjects aged 3.5 to 82 years showed a significant effect of age (P = .0207). The delay between death or enucleation and fixation also significantly affected the result (P = .0078). The mean (+/- S.E.M.) count for the 16 nerves was 1,244,005 +/- 20,033 fibers, gi...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：1984-06-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(98)00424-3
更新日期：1999-04-01 00:00:00
abstract：PURPOSE:To estimate point prevalence of uveal melanoma in the patients with germline BAP1 pathogenic variant. DESIGN:Cohort study with risk assessment using Bayesian analysis. METHODS:The point prevalence estimate was obtained by Bayes's rule of reverse conditional probabilities. The probability of uveal melanoma giv...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2020.12.005
更新日期：2020-12-11 00:00:00
abstract：PURPOSE:To report a case of migration of liquid silicone into the upper eyelid. DESIGN:Interventional case report. METHODS:A 32-year-old woman had an injection of liquid silicone into the subcutaneous tissue of the forehead. She developed a cystic mass in the upper eyelid 2 days postinjection. An excisional biopsy wa...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(03)00465-3
更新日期：2003-11-01 00:00:00
abstract：PURPOSE:To evaluate the effects of a dexamethasone intravitreous drug delivery system (dexamethasone DDS) in patients with persistent macular edema (ME) resulting from uveitis or Irvine-Gass syndrome. DESIGN:Randomized, prospective, single-masked, controlled trial. METHODS:Three hundred and fifteen patients with pers...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.ajo.2008.12.033
更新日期：2009-06-01 00:00:00
