Reconsideration of orchiectomy in the treatment of advanced prostatic carcinoma.

Abstract:

:The results of a large randomized prospective clinical trial conducted by the Veterans Administration Co-operative Urological Research Group (VACURG) in 1968 are updated and reevaluated. In this study, placebo, diethylstilbestrol (DES, 5 mg/day), orchiectomy plus placebo, and orchiectomy plus DES were compared in patients whose conditions were initially diagnosed as stage III and IV carcinoma of the prostate. Results showed that orchiectomy alone or in combination with estrogen did not improve overall survival rates in stage III and IV carcinoma of the prostate. In the two treatment groups receiving estrogen, however, there were fewer deaths due to cancer of the prostate, but this effect tended to be offset by an increased number of deaths due to cardiovascular causes. Deaths from other causes showed no particular pattern with respect to treatment. These studies showed that estrogen is more effective than orchiectomy in preventing deaths from cancer and that the addition of orchiectomy to estrogen does not offer any clear-cut advantage over estrogen therapy alone. If cancer symptoms necessitate treatment, initial therapy with estrogen is preferred. Orchiectomy should be reserved for those circumstances in which a patient is not reliable, cannot tolerate estrogens, or has severe cardiovascular disease.

journal_name

South Med J

journal_title

Southern medical journal

authors

Jordan WP Jr,Blackard CE,Byar DP

subject

Has Abstract

pub_date

1977-12-01 00:00:00

pages

1411-3

issue

12

eissn

0038-4348

issn

1541-8243

journal_volume

70

pub_type

临床试验,杂志文章,随机对照试验
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    pub_type: 杂志文章

    doi:

    authors: DiClemente RJ,Funkhouser E,Wingood G,Fawal H,Holmberg SD,Vermund SH

    更新日期:2002-04-01 00:00:00

  • Treatment of lactic acidosis.

    abstract::Severe lactic acidosis is often associated with poor prognosis. Recognition and correction of the underlying process is the major step in the treatment of this serious condition. Intravenous administration of sodium bicarbonate has been the mainstay in the treatment of lactic acidosis. Aggressive use of this therapeut...

    journal_title:Southern medical journal

    pub_type: 杂志文章,评审

    doi:10.1097/00007611-198107000-00018

    authors: Warner A,Vaziri ND

    更新日期:1981-07-01 00:00:00

  • Changing role of radiotherapy in the management of cancer of the esophagus.

    abstract:BACKGROUND:Cancer of the esophagus remains a highly lethal disease, but new treatment approaches that build onto traditional surgical and radiotherapeutic methods are making an impact on organ preservation while offering hope for improved survival. METHODS:Reviewed here are recent data from trials on the use of new ra...

    journal_title:Southern medical journal

    pub_type: 临床试验,杂志文章,随机对照试验,评审

    doi:10.1097/00007611-199911000-00003

    authors: Rich T

    更新日期:1999-11-01 00:00:00

  • Primary Pseudomonas pneumonia in a previously healthy man.

    abstract::A 29-year-old previously healthy man had a Pseudomonas aeruginosa pneumonia and bacteremia. Early recognition of the organism and institution of appropriate antibiotic therapy led to rapid clinical response and recovery. Although Pseudomonas is rarely the cause of pneumonia in a healthy host, it should be considered i...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-198302000-00033

    authors: Fishman H,Eaton B,Lipson A,Delaney MD

    更新日期:1983-02-01 00:00:00

  • Duodenal stricture: a complication of chronic fibrocalcific pancreatitis.

    abstract::Over the past 10 years, one of us (M.C.A.) has treated 92 patients who required operation for symptoms associated with alcohol-induced chronic fibrocalcific pancreatitis. Four of these patients had duodenal obstruction. All four had had lateral pancreaticojejunostomy to relieve pancreatic ductal obstruction and associ...

    journal_title:Southern medical journal

    pub_type: 杂志文章,评审

    doi:

    authors: Taylor SM,Adams DB,Anderson MC

    更新日期:1991-03-01 00:00:00

  • Anterior uveitis, inflammatory bowel disease, and ankylosing spondylitis in a HLA-B27-positive woman.

    abstract::A woman developed anterior uveitis at age 24, inflammatory bowel disease at age 29, and ankylosing spondylitis at age 45 by history. There were frequent recurrences. An HLA-B27 test was positive at age 53. The literature indicates that all of these conditions together in a HLA-B27-positive woman are uncommon. Physicia...

    journal_title:Southern medical journal

    pub_type: 杂志文章,评审

    doi:10.1097/01.smj.0000215747.80424.2d

    authors: Singleton EM,Hutson SE

    更新日期:2006-05-01 00:00:00

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    abstract::Sleep loss impairs ventilatory responsiveness to hypercapnia and hypoxia, and also interferes with performance on spirometry. To test the hypothesis that the decline in hypercapnic drive due to sleep loss is mediated by endorphin production, we measured loaded and unloaded CO2 response after injection of placebo and n...

    journal_title:Southern medical journal

    pub_type: 临床试验,杂志文章

    doi:10.1097/00007611-198701000-00004

    authors: Phillips B,Cooper KR,Newsome HH,Dewey WL

    更新日期:1987-01-01 00:00:00

  • Pyarthrosis simulating ruptured rotator cuff syndrome.

    abstract::A 50-year-old black man was admitted with a diagnosis of a ruptured rotator cuff syndrome two weeks after an injury to the right shoulder and treatment by intra-articular steroid injection. At operation pus and necrotic debris were found in the shoulder joint, but the rotator cuff was anatomically intact. Surgical deb...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-198206000-00037

    authors: Gordon EJ,Hutchful GA

    更新日期:1982-06-01 00:00:00

  • Acute buried bumper syndrome.

    abstract::Buried bumper syndrome (BBS) is an uncommon complication of percutaneous endoscopic gastrostomy (PEG) tube placement. This unusual phenomenon occurs when the internal bumper of a PEG tube erodes and migrates through the gastric wall and becomes lodged anywhere between the gastric wall and the skin. If not removed and ...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/SMJ.0b013e3181fa73d0

    authors: Khalil Q,Kibria R,Akram S

    更新日期:2010-12-01 00:00:00

  • Radiotherapeutic palliation of spinal epidural compression in small-cell lung cancer.

    abstract::Sixteen patients with spinal epidural compression by metastatic small-cell lung cancer were given radiotherapy for palliation. Lower limb motor deficit was the most prominent clinical manifestation. Neurologic dysfunction was commonly present for more than 48 hours before the diagnosis of compression. Median interval ...

    journal_title:Southern medical journal

    pub_type: 杂志文章,评审

    doi:10.1097/00007611-199203000-00008

    authors: Ampil FL,Abreo F

    更新日期:1992-03-01 00:00:00

  • Five cranial nerve palsies in a diabetic man.

    abstract::A patient with stable non-insulin-dependent diabetes mellitus had five successive cranial nerve palsies, all of which resolved. This syndrome is rarely encountered in patients with diabetes and in otherwise healthy individuals. ...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-198502000-00027

    authors: Brett AS

    更新日期:1985-02-01 00:00:00

  • Cytomegalovirus hepatitis mimicking an acute exacerbation of chronic hepatitis B.

    abstract::We report the case of a 29-year-old woman who had acute cytomegalovirus hepatitis superimposed on previously unrecognized chronic hepatitis B infection. We then review the diagnostic approach to acute hepatitis and positive hepatitis B surface antigen. ...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-199612000-00017

    authors: Zuschke CA,Herrera JL,Pettyjohn FS

    更新日期:1996-12-01 00:00:00

  • Synergistic effects of psyllium in the dietary treatment of hypercholesterolemia.

    abstract::We investigated psyllium fiber supplementation as a means of enhancing the cholesterol-lowering effect of the phase I American Heart Association diet. Fifty-nine subjects with total serum cholesterol (TC) levels ranging from 5.56 to 10.24 mmol/L (215 to 396 mg/dL) were given a 2-month dietary lead-in followed by 3 mon...

    journal_title:Southern medical journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00007611-199010000-00005

    authors: Neal GW,Balm TK

    更新日期:1990-10-01 00:00:00

  • Impact of minority physicians on health care.

    abstract:BACKGROUND:There is concern that anti-affirmative-action measures will negate gains made ill educating underrepresented minority physicians and that this underrepresentation may have a negative impact on access to health care for these same underrepresented groups. METHODS:A review of the literature was completed to e...

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    pub_type: 杂志文章,评审

    doi:10.1097/00007611-199811000-00003

    authors: Thurmond VB,Kirch DG

    更新日期:1998-11-01 00:00:00

  • ECG changes with elevated troponin I in a patient with tension pneumothorax.

    abstract::An 86-year-old man presented with sudden onset of dyspnea during hospitalization. Initial electrocardiography (ECG) showed poor R-wave progression of precordial leads with elevation of troponin I. Tension pneumothorax was subsequently diagnosed and the ECG returned to normal after resolution of clinical compromise. ...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/SMJ.0b013e3181aeda06

    authors: Chan WH,Lin CS,Yang SP,Cheng SM

    更新日期:2009-09-01 00:00:00

  • Blind-ending branch of a bifid ureter.

    abstract::An example of a blind-ending branch of a bifid ureter in a woman presenting with a urinary tract infection is reported. Definition, diagnosis, and treatment of this anomaly are discussed. ...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-197907000-00031

    authors: Dalton DL

    更新日期:1979-07-01 00:00:00

  • Remission of facial and scalp hyperhidrosis with clonidine hydrochloride and topical aluminum chloride.

    abstract::Axillary and palmar hyperhidrosis are featured prominently in the literature, but no previous studies have detailed a treatment regimen for specific excessive localized sweating of the face and scalp. In this report, a patient was treated for this condition with a combination of clonidine hydrochloride (0.3 mg to 0.4 ...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:

    authors: Torch EM

    更新日期:2000-01-01 00:00:00

  • Lymphangiomyomatosis with chylous effusions.

    abstract::We report two cases of lymphangiomyomatosis with pleural and peritoneal chylous effusions, one without pulmonary involvement. The first patient died after seven years. The second received external irradiation to control the chylous ascites and remains alive 12 years later. The disease appears to be estrogen-dependent,...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-198408000-00024

    authors: Sheth RA,Greenberg SD,Jenkins DE,Beall AC

    更新日期:1984-08-01 00:00:00

  • Autoimmune Neutropenia Updates: Etiology, Pathology, and Treatment.

    abstract::Autoimmune neutropenia (AIN) is defined as a neutrophil count <1.5 × 109/L caused by increased peripheral destruction of neutrophils from an underlying autoimmune mechanism in which autoantibodies are directed against a patient's own neutrophils. AIN has a multifactorial etiology ranging from an idiopathic primary phe...

    journal_title:Southern medical journal

    pub_type: 杂志文章,评审

    doi:10.14423/SMJ.0000000000000637

    authors: Afzal W,Owlia MB,Hasni S,Newman KA

    更新日期:2017-04-01 00:00:00

  • Increased incidence of bacteremia in Haitian children with sickle cell anemia.

    abstract::Children with sickle cell anemia who were less than 5 years old were observed over a three-year period. Those born to recent Haitian immigrants accounted for 108.4 patient-years. They had seven episodes of Streptococcus pneumoniae bacteremia and five due to Haemophilus influenzae for rates of 6.5 and 4.6 episodes per ...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-198907000-00009

    authors: Pegelow CH

    更新日期:1989-07-01 00:00:00

  • Reentry monitoring in the treatment of physicians with substance dependence.

    abstract::A total of 37 physicians and other health care professionals have been accepted into a monitoring and advocacy program for an average of 24 months. Thirty-five are working in their profession, one is in treatment, and one has repeatedly relapsed and is no longer practicing medicine (an overall improvement rate of 97%)...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-199409000-00003

    authors: Roy AK 3rd

    更新日期:1994-09-01 00:00:00

  • Abdominal pain resulting from cerebrospinal fluid pseudocyst and cholelithiasis.

    abstract::Patients treated with ventriculoperitoneal (VP) shunt procedures for hydrocephalus may have abdominal pain related to complications stemming from the shunt tubing itself or to other intra-abdominal disease. In patients with VP shunts, usually children, lack of absorption of cerebrospinal fluid (CSF) may produce a pain...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-199208000-00014

    authors: Engelhard HH,Miller FB

    更新日期:1992-08-01 00:00:00

  • The variant form of angina pectoris.

    abstract::Variant angina pectoris, usually not precipitated by exertion or emotional stress, often is more severe and lasts longer than classic angina. The pain tends to recur at about the same time each day. Arrhythmias, usually ventricular, occur in about 50% of cases during the peak of pain. Electrocardiograms show a charact...

    journal_title:Southern medical journal

    pub_type: 杂志文章,评审

    doi:10.1097/00007611-197603000-00034

    authors: Siegel JS

    更新日期:1976-03-01 00:00:00

  • Ultrasonic diagnosis of obstructed renal duplication and ureterocele.

    abstract::The diagnoses of complete obstruction in a duplicated renal collecting system and ureterocele can be made with a high degree of confidence by ultrasound. Two children presenting with abdominal masses were examined by gray scale ultrasonography which demonstrated large cystic masses dorsal to and displacing the lower p...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-198008000-00018

    authors: Morgan CL,Grossman H,Trought WS,Oddson TA

    更新日期:1980-08-01 00:00:00

  • Asacol®-induced neutropenia resolution without the use of granulocyte colony-stimulating factor.

    abstract::We report a case of neutropenia and gram-negative septicemia in a 73-year-old male with ulcerative colitis. During the hospital course, medications were adjusted according to rare accounts of drug-induced neutropenia. While the substitution of propafenone for another antiarrhythmic brought about no change in the patie...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/SMJ.0b013e3181f46647

    authors: Fowler BT,Gupta T,Bilal M

    更新日期:2010-11-01 00:00:00

  • Aldosteronism in pregnancy: association with virilization of female offspring.

    abstract::We have described a case of maternal primary aldosteronism in which there is virilization of the female offspring. The most common causes of virilization are considered unlikely on the basis of clinical and laboratory data. The report illustrates the exacerbation of aldosteronism that occurs postpartum and emphasizes ...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:

    authors: Elterman JJ,Hagen GA

    更新日期:1983-04-01 00:00:00

  • Point-of-Care Ultrasound in Established Settings.

    abstract::The original and most widely accepted applications for point-of-care ultrasound (POCUS) are in the settings of trauma, shock, and bedside procedures. Trauma was the original setting for the introduction of POCUS and has been standardized under the four-plus view examination called the Focused Assessment with Sonograph...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.14423/SMJ.0000000000000838

    authors: Morrow D,Cupp J,Schrift D,Nathanson R,Soni NJ

    更新日期:2018-07-01 00:00:00

  • Angiotensin receptor blockers for management of hypertension.

    abstract::The renin-angiotensin-aldosterone system (RAAS) plays a major role in blood pressure regulation and is thus an important therapeutic target in the management of hypertension. Angiotensin receptor blockers (ARBs), which interrupt RAAS overactivity by blocking a specific receptor that mediates the pathogenic activity of...

    journal_title:Southern medical journal

    pub_type: 杂志文章,评审

    doi:10.1097/SMJ.0b013e3181e1e2da

    authors: Catanzaro DF,Frishman WH

    更新日期:2010-07-01 00:00:00

  • Pseudoepitheliomatous hyperplasia mistaken for cancer after delayed reconstruction.

    abstract::Pseudoepitheliomatous hyperplasia (PEH) arises in areas of chronic inflammation and can be mistaken for squamous cell carcinoma, leading to unnecessary removal of more tissue. We present a study of 21 patients having delayed reconstruction of defects left by Mohs micrographic surgery (MMS) to remove facial skin cancer...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-199504000-00014

    authors: Calhoun KH,Wagner RF Jr,Kumar D,Hokanson JA

    更新日期:1995-04-01 00:00:00

  • Characteristics of severe hypoglycemia in the patient with insulin-dependent diabetes.

    abstract::To avoid, delay, or ameliorate the microvascular complications of diabetes, intensive insulin therapy with the goal of normoglycemia is required. In most patients with insulin-dependent diabetes mellitus (IDDM), this cannot be achieved because of severe hypoglycemia, which is one of the major causes of morbidity in di...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-199406000-00007

    authors: Bell DS,Cutter G

    更新日期:1994-06-01 00:00:00