Abstract:
BACKGROUND:The vasodilatator effects of testosterone have been widely studied and demonstrated. Based on previous studies of these vasodilatatory activities, we hypothesized that testosterone might have potential effects on subarachnoid hemorrhage-induced cerebral vasospasm. METHODS:Thirty-two adult male New Zealand white rabbits were randomly divided into four groups of eight rabbits in each group: group 1 (control); group 2 (subarachnoid hemorrhage); group 3 (subarachnoid hemorrhage + vehicle); and group 4 (subarachnoid hemorrhage + testosterone). Testosterone (15 mg/kg, intraperitoneally) was administered 5 min after the intracisternal blood injection and continued for 72 h once per day in the same dose for group 4. Animals were killed 72 h after subarachnoid hemorrhage. Basilar artery cross-sectional areas, arterial wall thicknesses, and hippocampal degeneration scores were evaluated in all groups. RESULTS:Intraperitoneal administration of testosterone was found to attenuate cerebral vasospasm and provide neuroprotection after subarachnoid hemorrhage in rabbits. Testosterone treatment was determined to be effective at increasing the luminal area and reducing the wall thickness of the basilar artery. CONCLUSIONS:Our findings show that testosterone has some preventive effects on SAH-induced vasospasm and secondary neuronal injury in rabbits. We propose that the vasodilatatory activity of testosterone is due to its effects on inhibiting calcium channels, activating potassium channels, augmenting nitric oxide synthesis, and inhibiting oxidant stress and inflammation.
journal_name
Acta Neurochir (Wien)journal_title
Acta neurochirurgicaauthors
Gürer B,Turkoglu E,Kertmen H,Karavelioglu E,Arikok AT,Sekerci Zdoi
10.1007/s00701-014-2211-9subject
Has Abstractpub_date
2014-11-01 00:00:00pages
2111-20; discussion 2120issue
11eissn
0001-6268issn
0942-0940journal_volume
156pub_type
杂志文章abstract::The authors outline the possible approaches to vertebromedullary tumours of the thoraco-lumbar spine using unilateral or bilateral transverso-arthro-pediculectomy and corporectomy. In a personal series of 20 cases. The technique and indications are described and the results. ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01456263
更新日期:1986-01-01 00:00:00
abstract::Among 64 patients with hemifacial spasm (HFS) and 60 with trigeminal neuralgia (TN) treated by microvascular decompression (MVD), repeated MVD performed on 3 cases with HFS resulted in the absence of spasm in all cases. In 7 cases with TN, this technique resulted in complete remission in 2, recurrence in 3, and no pai...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01400583
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:An Afghani man presented to a U.S. military facility in Afghanistan with a 3-month history of clear fluid from his left naris and frequent sinusitis. Eleven years earlier, he had been struck in the forehead by an object falling from the sky. MATERIALS AND METHODS:Neurologic examination revealed decreased se...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-008-0148-6
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND:Middle cerebral artery (MCA) aneurysms are among the more challenging aneurysms for endovascular treatment. We report a contemporary 5-year experience with endovascular therapy for MCA aneurysms at a high-volume neurovascular center. METHODS:Review of prospectively maintained intracranial aneurysm database....
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-012-1594-8
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND:For the treatment of medically refractory movement disorders such as Parkinson's disease, essential tremor and primary dystonia, deep brain stimulation (DBS) has become one of the main treatment options. The targets for implantation of the stimulation electrodes are various nuclei within the basal ganglia or...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s007010200065
更新日期:2002-05-01 00:00:00
abstract::Three hundred and sixty-four patients who suffered a subarachnoid haemorrhage from an aneurysm at either the anterior (ACA) or posterior (PCA) communicating artery location and who were not surgically treated have been followed for up to 21 years in order to study the late morbidity and mortality. For the 213 patients...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01728858
更新日期:1982-01-01 00:00:00
abstract:BACKGROUND:Side-to-side neurorrhaphy may protect the denervated end organ and preserve the initial connection with proximal stump. We examined the effect of protective side-to-side anastomosis on nerve and end organ regeneration in proximal nerve injury model. METHODS:The left common peroneal nerve of 24 Sprague Dawle...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-019-03835-2
更新日期:2019-04-01 00:00:00
abstract::Radiosurgery is either a primary or an adjunctive management approach used to treat patients with vestibular schwannomas. We sought to determine outcomes measuring the potential benefits against the neurological risks in patients who underwent radiosurgery after previous microsurgical subtotal resection or recurrence ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-002-0950-5
更新日期:2002-07-01 00:00:00
abstract::Vascular endothelium synthesizes mediators which either cause vasorelaxation or vasoconstriction. The purpose of this study is to investigate the role of these mediators in the pathogenesis of cerebral vasospasm. An inhibitor of endothelium-derived relaxing factor is haemoglobin; endothelium removal by triton X-100 an...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01401136
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:Most surgical teams currently consider that endoscopy has become the "gold standard" technique for the transsphenoidal approach to pituitary surgery. Pituitary adenomas are commonly benign tumours and should benefit from the least invasive approach. METHOD:In Foch Hospital, from 2006 to 2020, 2835 patients ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-020-04542-z
更新日期:2020-08-29 00:00:00
abstract::Aneurysms of the vertebro-basilar junction area have been considered the most difficult to be surgically treated because of their deep location, the proximity of the brain stem and the cranial nerves. However, at present, new endovascular techniques and new transbasal surgical approaches offer valuable management stra...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF02747192
更新日期:1997-01-01 00:00:00
abstract::Being motor nerves neurinomas originating from ocular nerves are very rare, unless associated with neurofibromatosis. Authors describe two cases of oculomotor nerve i.e. third nerve, Schwann cell tumours. One of them presented as a cavernous sinus mass in a middle aged lady while the other was a middle aged man with a...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s007010050229
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:Scientific research can offer the joy of discovery. For many graduating neurosurgeons, often, a seminar, class, or instructional module is their first and only formal exposure to the world of conducting research responsibly, to write down and report the results of such research. The pressure to publish scien...
journal_title:Acta neurochirurgica
pub_type: 杂志文章,评审
doi:10.1007/s00701-020-04546-9
更新日期:2021-01-01 00:00:00
abstract:INTRODUCTION:The gold-standard treatment for symptomatic anterior skull base meningiomas is surgical resection. The endoscope-assisted supraorbital "keyhole" approach (eSKA) is a promising technique for surgical resection of olfactory groove (OGM) and tuberculum sellae meningioma (TSM) but has yet to be compared with t...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-020-04544-x
更新日期:2020-09-05 00:00:00
abstract::Selection of the approach and technique for surgical repair of aneurysm of the vertebrobasilar artery system is mainly based on angiographic features. This report emphasizes that planning the surgical procedure should also include preoperative evaluation of the individual skull base configuration, as well as the relat...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01428505
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND:Even in specialized centers, suboptimal aneurysm clipping can be as high as 12%. Intraoperative fluorescence angiography with indocyanine green and, more recently, fluorescein sodium have been shown to be a good method for intraoperative flow assessment. However, the cost with the apparatus it entails limits...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-019-03904-6
更新日期:2019-07-01 00:00:00
abstract::This paper is based on a study of sixty cases of cranio-cerebral erosion treated in the Department of Neurosurgery. All India Institute of Medical Sciences, New Delhi during the last 20 years. This constitutes the largest series, so far reported from anywhere. It has provided a unique opportunity to get a comprehensiv...
journal_title:Acta neurochirurgica
pub_type: 杂志文章,评审
doi:10.1007/BF01400508
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND:In patients with a vestibular schwannoma, some studies have reported that useful hearing preserved initially after surgery deteriorates gradually in the long term. Studies with more patients are needed to clarify the maintenance rate of postoperative hearing function and to identify prognostic of hearing fun...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-020-04523-2
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:The aim of this study was to assess if transforaminal steroid injections applied to cohort of patients waiting for cervical disc surgery, reduce the pain of cervical radiculopathy and hence reduce the need for surgical intervention. Cervical radiculopathy due to cervical disc herniation or spondylosis is a c...
journal_title:Acta neurochirurgica
pub_type: 临床试验,杂志文章
doi:10.1007/s00701-005-0542-2
更新日期:2005-10-01 00:00:00
abstract::A modification of the previous methods of producing cerebral ischaemia in rats (Koizumi et al., Longa et al.), using an intraluminal thread technique, is described. The middle cerebral artery is occluded by introducing a simple 3-0 nylon thread (0.20-0.249 mm in diameter) through the internal carotid artery in the nec...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01403007
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:Drain insertion following chronic subdural haematoma (CSDH) evacuation reduces recurrence and improves outcomes. The mechanism of this improvement is uncertain. We assessed whether drains result in improved postoperative imaging, and which radiological factors are associated with recurrence and functional ou...
journal_title:Acta neurochirurgica
pub_type: 杂志文章,多中心研究
doi:10.1007/s00701-020-04356-z
更新日期:2020-06-01 00:00:00
abstract::Early diagnosis of thoracic disc herniations has become more common with the advent of spinal magnetic resonance imaging (MRI). This early diagnosis combined with choosing the optimal surgical approach, to ensure adequate decompression without excessive cord and root manipulation, will achieve the optimum results. It ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01402509
更新日期:1991-01-01 00:00:00
abstract::Therapy for vasogenic brain oedema (VBE) is still an unsolved problem. Experimental work with the aim of establishing an oncotherapeutic option is presented. VBE is performed by focal freeze injury in rats. Using a stereotactic head holder hypo- or hyperosmolar human serum albumin is administered via the intraventricu...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01412002
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:Complex aneurysm shape is a predominant risk factor for aneurysm rupture but its impact on clinical outcome after clipping remains unclear. The objective of the present study was to compare complications and morbidity after clipping of unruptured single-sac aneurysms (SSAs) and aneurysms with multiple sacs (...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-018-3675-9
更新日期:2018-11-01 00:00:00
abstract:INTRODUCTION:Navigated transcranial magnetic stimulation (nTMS) is increasingly used for preoperative mapping of motor function, and clinical evidence for its benefit for brain tumor patients is accumulating. In respect to language mapping with repetitive nTMS, literature reports have yielded variable results, and it i...
journal_title:Acta neurochirurgica
pub_type: 杂志文章,评审
doi:10.1007/s00701-017-3187-z
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:Vestibular schwannoma (VS) is a benign tumor originating from the vestibulocochlear nerve. The optimal treatment strategy is debated, since surgery may result in iatrogenic facial nerve injury. We report the results of VS surgery in a population-based unselected cohort in a center with access to Cyber Knife ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-019-04055-4
更新日期:2020-01-01 00:00:00
abstract::This report describes a rare case of a distal anterior choroidal artery aneurysm which developed intraventricular haemorrhage without subarachnoid haemorrhage as shown on computerized tomographic (CT) scan. A 69-year-old hypertensive man suddenly became unconscious. An emergency CT scan showed a severe intraventricula...
journal_title:Acta neurochirurgica
pub_type: 杂志文章,评审
doi:10.1007/s007010050082
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:Multicentric WHO grade II gliomas constitute a rare entity. Their pathogenesis and treatment are still a matter of debate. OBJECTIVE:We present a 23 year-old female with two synchronous but separate WHO grade II oligodendrogliomas in the temporal and frontal lobes. CLINICAL FEATURES:The two lesions showed ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-009-0306-5
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND:Nicardipine prolonged release implants (NPRI) have been shown to decrease the incidence of cerebral vasospasm and infarcts significantly in patients after aneurysmal subarachnoid haemorrhage (SAH) following microsurgical clipping. Yet, the comparison with results after endovascular coiling is lacking. This s...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-011-1129-8
更新日期:2011-11-01 00:00:00
abstract::Cavernous hemangiomas are most commonly found within the subcortical neural parenchyma near the fissura Rolandi, in the basal ganglia, or in the brain stem. Because of advancing neuro-imaging technology and thus resulting in a higher incidence of cavernous hemangiomas they have rising impact in neurosurgery. We presen...
journal_title:Acta neurochirurgica
pub_type: 杂志文章,评审
doi:10.1007/s00701-005-0567-6
更新日期:2005-10-01 00:00:00