Abstract:
:Coxsackie B viruses are a common cause of viral myocarditis in humans. A murine model of the human disease has been developed using Coxsackievirus group B, type 3 and inbred Balb/c mice. Infection of T lymphocyte deficient mice does not result in significant myocarditis indicating the importance of T cells in this disease. The virus can be isolated from the hearts of T cell deficient and normal mice in equal concentrations. Virus elimination presumably is mediated by virus specific neutralizing antibody induced in both groups. T lymphocytes, natural killer cells and macrophage obtained from normal virus infected mice are all capable of lysing myofibers in vitro. Maximum lysis is obtained with the cytolytic T cells. When these cell populations or Coxsackievirus immune antibody were adoptively transferred into T lymphocyte deficient animals infected with the virus, only animals given T cells developed significant myocarditis.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Huber SA,Job LPdoi
10.1007/978-1-4684-4472-8_29subject
Has Abstractpub_date
1983-01-01 00:00:00pages
491-508eissn
0065-2598issn
2214-8019journal_volume
161pub_type
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