Detection of transforming growth factor-alpha messenger RNA in normal and chemically transformed hamster oral epithelium by in situ hybridization.

abstract：:The discovery of oncogenic driver mutations and the subsequent developments in targeted therapies have led to improved outcomes for subsets of lung cancer patients. The identification of additional oncogenic and drug-sensitive alterations may similarly lead to new therapeutic approaches for lung cancer. We identify an...

journal_title：Cancer research

authors： Tanizaki J,Ercan D,Capelletti M,Dodge M,Xu C,Bahcall M,Tricker EM,Butaney M,Calles A,Sholl LM,Hammerman PS,Oxnard GR,Wong KK,Jänne PA

更新日期：2015-08-01 00:00:00

abstract：:ErbB2 and ErbB3, two members of the ErbB family, form a high-affinity heregulin coreceptor that elicits potent mitogenic and transforming signals, and clinical studies indicate that these receptors play an important role in tumor incidence and progression. To determine whether N-glycosylation is involved in the functi...

journal_title：Cancer research

authors： Yokoe S,Takahashi M,Asahi M,Lee SH,Li W,Osumi D,Miyoshi E,Taniguchi N

更新日期：2007-03-01 00:00:00

abstract：:Resistance to antineoplastic drugs is a major problem in the clinical management of cancer. Previous studies have demonstrated that the cytotoxicity of certain anticancer drugs is increased by lowering the glutathione (GSH) levels with buthionine sulfoximine (BSO), a specific inhibitor of gamma-glutamylcysteine synthe...

journal_title：Cancer research

authors： Dusre L,Mimnaugh EG,Myers CE,Sinha BK

更新日期：1989-02-01 00:00:00

abstract：:We have demonstrated the intracellular expression of sex hormone-binding globulin (SHBG) exon VII splicing variant mRNA in human uterine endometrial cancer using the reverse transcription-PCR-Southern blot and DNA sequencing analyses. Analysis of the missing base pairs proved that they corresponded to the entire exon ...

journal_title：Cancer research

authors： Misao R,Nakanishi Y,Fujimoto J,Tamaya T

更新日期：1997-12-15 00:00:00

abstract：:Oncogenic transformation of mouse 10T 1/2 fibroblasts induced upon exposure to X-ray or N-methyl-N'-nitro-N-nitrosoguanidine was suppressed if lipopolysaccharide (LPS) was present in the culture medium. The suppressive effect of LPS was exerted within 24 h after irradiation. Suppression was dependent on the concentrat...

journal_title：Cancer research

authors： Sakiyama H,Yasukawa M,Terasima T,Kanegasaki S

更新日期：1986-08-01 00:00:00

abstract：:The mechanism of the previously reported cytotoxicity of liposomes containing plant phosphatidylinositol (PI) against numerous tumor cell lines was examined in detail by using liposomes containing synthetic PI specifically labeled either with radioactive myo-inositol, or in the sn-2 position with radioactive linoleic ...

journal_title：Cancer research

authors： Jett M,Chudzik J,Alving CR,Stanacev NZ

更新日期：1985-10-01 00:00:00

abstract：:Growing epidemiologic evidence supports chronic inflammation as a mechanism of ovarian carcinogenesis. An association between a circulating marker of inflammation, C-reactive protein (CRP), and ovarian cancer risk has been consistently observed, yet, potential heterogeneity of this association by tumor and patient cha...

journal_title：Cancer research

authors： Peres LC,Mallen AR,Townsend MK,Poole EM,Trabert B,Allen NE,Arslan AA,Dossus L,Fortner RT,Gram IT,Hartge P,Idahl A,Kaaks R,Kvaskoff M,Magliocco AM,Merritt MA,Quirós JR,Tjonneland A,Trichopoulou A,Tumino R,van Gils

更新日期：2019-10-15 00:00:00

abstract：:This study investigated the effect of recombinant human tumor necrosis factor (rhTNF) on hydroxyl radical production by established cell lines in vitro, and its implication in the killing of tumor cells by rhTNF. During incubation of TNF sensitive mouse tumorigenic fibroblast L-M cells (2 X 10(7) cells) in the presenc...

journal_title：Cancer research

authors： Yamauchi N,Kuriyama H,Watanabe N,Neda H,Maeda M,Niitsu Y

更新日期：1989-04-01 00:00:00

abstract：:T cells expressing human leukemia virus (HTLV) type 1, the etiological agent of adult T-cell leukemia, are remarkably resistant to conventional chemotherapy, and the need for drugs that effectively kill these cells is apparent. Here we show that roscovitine, an inhibitor of cyclin-dependent kinases (CDKs), induces the...

journal_title：Cancer research

authors： Mohapatra S,Chu B,Wei S,Djeu J,Epling-Burnette PK,Loughran T,Jove R,Pledger WJ

更新日期：2003-12-01 00:00:00

abstract：:Whether the apparent efficacy of a specific kinase inhibitor is attributable solely to inhibition of its primary target, or to combined inhibition of additional unidentified kinases, is a critical issue in cancer therapy. We used a chemical genetic approach to generate a selective inhibitor of v-erbB [a transforming a...

journal_title：Cancer research

authors： Fan QW,Specht KM,Zhang C,Goldenberg DD,Shokat KM,Weiss WA

更新日期：2003-12-15 00:00:00

abstract：:Methylglyoxal-bis(guanylhydrazone) (MGBG) is a polycationic drug which is useful in the chemotherapy of lymphoid and myeloid proliferative disorders. The drug has recently been shown to produce selective ultrastructural damage to the mitochondria of proliferating cell populations. It is important to understand the mol...

journal_title：Cancer research

authors： Feuerstein B,Porter CW,Dave C

更新日期：1979-10-01 00:00:00

abstract：:To determine whether the toxic effects and changes in many cell functions caused by antitumor 1-nitroacridines are related to their enzymatically mediated covalent interstrand DNA cross-linking (J. Konopa, J. W. Pawlak, and K. Pawlak. Chem.-Biol. Interact., 43: 175-197, 1983), the cross-linking potency of the derivati...

journal_title：Cancer research

authors： Pawlak K,Pawlak JW,Konopa J

更新日期：1984-10-01 00:00:00

abstract：:Curcumin, a natural compound, is a well-known chemopreventive agent with potent anticarcinogenic activity in a wide variety of tumor cells. Curcumin inhibits cancer cell proliferation in part by suppressing cyclin D1 and inducing expression of the cyclin-dependent kinase inhibitor p21(Waf1/Cip1). Both p53-dependent an...

journal_title：Cancer research

authors： Choi BH,Kim CG,Bae YS,Lim Y,Lee YH,Shin SY

更新日期：2008-03-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF)-C is a lymphangiogenic factor implicated in lymphatic metastasis. In this study, we investigated the role of the type I insulin-like growth factor receptor (IGF-IR) in the regulation of VEGF-C expression. We used Lewis lung carcinoma subline M-27 cells transfected with human I...

journal_title：Cancer research

authors： Tang Y,Zhang D,Fallavollita L,Brodt P

更新日期：2003-03-15 00:00:00

abstract：:To assess whether CYP3A4 and CYP3A7 have a similar capacity to activate carcinogenic mycotoxins, we established cell lines stably expressing human CYP3A4 and CYP3A7, which are adult- and fetal-specific forms of cytochrome P450 in human livers, respectively. Each cDNA was introduced into CR-119 cells which had been est...

journal_title：Cancer research

authors： Hashimoto H,Nakagawa T,Yokoi T,Sawada M,Itoh S,Kamataki T

更新日期：1995-02-15 00:00:00

abstract：:4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is activated to DNA alkylating species via two different alpha-hydroxylation pathways. Methylene hydroxylation leads to DNA methylation, whereas methyl hydroxylation yields DNA pyridyloxobutylation. We have developed a high-pressure liquid chromatography assay utili...

journal_title：Cancer research

authors： Peterson LA,Mathew R,Hecht SS

更新日期：1991-10-15 00:00:00

abstract：:The formation of adducts of benzo(a)pyrene metabolites on DNA was investigated in endometrial tissue from humans, hamsters, mice, and rats. anti-Benzo(a)pyrene-7,8-diol-9,10-epoxide was the predominant adduct identified in all the species studied. The amount of (+)-anti-benzo(a)pyrene-7,8-diol-9,10-epoxide bound to DN...

journal_title：Cancer research

authors： Kulkarni MS,Calloway K,Irigaray MF,Kaufman DG

更新日期：1986-06-01 00:00:00

abstract：:To directly examine a multistage carcinogenesis model and the role of UV light in human tissues, we grafted human skin onto mice with severe combined immunodeficiency disease. We found that the maximum dose of UV radiation in the B range (UVB; 280-320 nm) tolerated by these grafts was 500 J/m2 three times weekly. One ...

journal_title：Cancer research

authors： Soballe PW,Montone KT,Satyamoorthy K,Nesbit M,Herlyn M

更新日期：1996-02-15 00:00:00

abstract：:The genetic status of cyclin genes was examined in a panel of 47 colorectal carcinoma cell lines. Cyclin D2 was found to be amplified in one tumor and cyclin E in another. In each of the two cases, the amplified cyclin gene was overexpressed at the protein or mRNA level. Cyclin D1, previously shown to be amplified in ...

journal_title：Cancer research

authors： Leach FS,Elledge SJ,Sherr CJ,Willson JK,Markowitz S,Kinzler KW,Vogelstein B

更新日期：1993-05-01 00:00:00

abstract：:Discoidin domain receptor 1 (DDR1) is a receptor tyrosine kinase activated by various types of collagens and is known to play a role in cell attachment, migration, survival, and proliferation. However, little is known about the molecular mechanism(s) underlying the role of DDR1 in cancer. We report here that DDR1 indu...

journal_title：Cancer research

authors： Das S,Ongusaha PP,Yang YS,Park JM,Aaronson SA,Lee SW

更新日期：2006-08-15 00:00:00

abstract：:Expression of the ectonucleotidase CD73 by tumor cells, stromal cells, and immune cells is associated in cancer with immune suppression. In this study, we investigated the role of CD73 on the activity of the anti-HER2/ErbB2 monoclonal antibody (mAb) trastuzumab. In a prospective, randomized phase III clinical trial ev...

journal_title：Cancer research

authors： Turcotte M,Allard D,Mittal D,Bareche Y,Buisseret L,José V,Pommey S,Delisle V,Loi S,Joensuu H,Kellokumpu-Lehtinen PL,Sotiriou C,Smyth MJ,Stagg J

更新日期：2017-10-15 00:00:00

abstract：:Gene targeting studies in mice have shown that the transcription factor Ikaros plays an essential role in lymphoid development and as a tumor suppressor in T cells, whereas the related gene Aiolos functions as a tumor suppressor in B cells. We analyzed the expression levels of the Ikaros gene family, Ikaros and Aiolos...

journal_title：Cancer research

authors： Nakase K,Ishimaru F,Avitahl N,Dansako H,Matsuo K,Fujii K,Sezaki N,Nakayama H,Yano T,Fukuda S,Imajoh K,Takeuchi M,Miyata A,Hara M,Yasukawa M,Takahashi I,Taguchi H,Matsue K,Nakao S,Niho Y,Takenaka K,Shinagawa K,

更新日期：2000-08-01 00:00:00

abstract：:The immunobiology of Friend erythroleukemia virus (FLV) has been the focal point of much research into immunological control of leukemia. We have been studying a murine model in which a rapidly fatal FLV infection of DBA/2 mice is suppressed to a dormant state by treatment with statolon, a double stranded RNA extract ...

journal_title：Cancer research

authors： DiCicco LM,Truitt GA,Wheelock EF

更新日期：1986-01-01 00:00:00

abstract：:The aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 (AIMP2) splice variant designated DX2 is induced by cigarette smoke carcinogens and is often detected in human lung cancer specimens. However, the function of DX2 in lung carcinogenesis is obscure. In this study, we found that DX2 expression w...

journal_title：Cancer research

authors： Oh AY,Jung YS,Kim J,Lee JH,Cho JH,Chun HY,Park S,Park H,Lim S,Ha NC,Park JS,Park CS,Song GY,Park BJ

更新日期：2016-08-15 00:00:00

abstract：:To test the hypothesis that genetic instability correlates with malignant potential, we compared the rate of generation of marker chromosomal abnormalities in clones of B16 F1 and B16 F10 murine melanoma. These rates were estimated through an adaptation of fluctuation analysis of Luria and Delbruck (S. E. Luria and M....

journal_title：Cancer research

authors： Kendal WS,Wang RY,Hsu TC,Frost P

更新日期：1987-07-15 00:00:00

abstract：:Metallothioneins (MT) are major cysteine-rich proteins with poorly characterized functions. We have examined the MT amount, isotype expression, and subcellular distribution in 4 human hormone-independent prostatic carcinoma cell lines. Both PC-3 and DU-145 cells were thiol-rich cells with similar MT and glutathione le...

journal_title：Cancer research

authors： Kondo Y,Kuo SM,Watkins SC,Lazo JS

更新日期：1995-02-01 00:00:00

abstract：:The bilirubin-binding ability of human alpha-fetoproteins, which were purified from fetal cord serum and from ascites fluid of a hepatoma-bearing patient, was examined by the difference spectrum and the Jacobsen peroxidase methods. The difference spectrum observed as a result of the specific binding of bilirubin to al...

journal_title：Cancer research

authors： Aoyagi Y,Ikenaka T,Ichida F

更新日期：1979-09-01 00:00:00

abstract：:The ability of four steroids and three bile acids to promote the appearance of hyperplastic foci and hyperplastic nodules initiated by diethylnitrosamine (DEN) in the liver of male Fischer rats was tested and compared with that of the known promoter phenobarbital (PB, 0.05%) as a standard value. Two weeks after a sing...

journal_title：Cancer research

authors： Cameron RG,Imaida K,Tsuda H,Ito N

更新日期：1982-06-01 00:00:00

abstract：:Some clinical studies suggest that timing of surgery during specific menstrual phases may influence the chances of survival for premenopausal women with breast cancer, whereas other studies failed to find this effect. Because most breast cancer deaths are attributable to metastases, we hypothesized that aspects of the...

journal_title：Cancer research

authors： Vantyghem SA,Postenka CO,Chambers AF

更新日期：2003-08-15 00:00:00

abstract：:Mutations that alter normal splice patterns and genomic rearrangements are common causes of hereditary diseases including hereditary nonpolyposis colorectal cancer. However, abnormal transcripts can be difficult to detect and interpret because splicing patterns are often heterogeneous even in normal cells. Standard te...

journal_title：Cancer research

authors： Nakagawa H,Yan H,Lockman J,Hampel H,Kinzler KW,Vogelstein B,De La Chapelle A

更新日期：2002-08-15 00:00:00