Human and rabbit platelets form platelet-activating factor in response to calcium ionophore.

abstract：:Cathepsin A-like enzyme released from human platelets by thrombin hydrolyzed at the highest rate Cbz-Phe-Ala, Cbz-Phe-Met and Cbz-Phe-Leu, did not require activators and was inhibited by DFP, DCI and mercurial compounds (mersalyl acid, PCMS, PCMB and HgCl2). The optimum activity of secreted enzyme was at pH 5.0-6.0. C...

journal_title：Thrombosis research

authors： Ostrowska H

更新日期：1997-06-01 00:00:00

abstract：:Lp(a) lipoprotein contains a unique apolipoprotein, apolipoprotein (a), that has a striking homology with plasminogen. This homology has brought forward speculations as to an inhibitory effect of Lp(a) lipoproteins on fibrinolysis. The present investigation was undertaken to study the influence of Lp(a) lipoprotein on...

journal_title：Thrombosis research

authors： Halvorsen S,Skjønsberg OH,Berg K,Ruyter R,Godal HC

更新日期：1992-11-01 00:00:00

abstract：:The effects of ticlopidine treatment (250 mg b.i.d. for 21 months) on fibrinogen and other rheological variables, as compared to placebo, were studied in 44 patients with intermittent claudication due to peripheral arterial occlusive disease. Blood samples were collected every 3 months during this double-blind, random...

journal_title：Thrombosis research

authors： Palareti G,Poggi M,Torricelli P,Balestra V,Coccheri S

更新日期：1988-12-15 00:00:00

abstract：:Clinically unsuspected pulmonary embolism (UPE) is frequently diagnosed in cancer patients undergoing routine computed tomography scans for staging purposes or treatment response evaluation. The reported incidence of UPE ranges from 1% to 5% which probably represents an underestimation. A significant proportion of can...

journal_title：Thrombosis research

authors： van Es N,Bleker SM,Di Nisio M

更新日期：2014-05-01 00:00:00

abstract：:In order to choose the proper method for evaluating the antithrombin activity in samples of chitosan polysulphate (CP) with different polymerization degrees and sulphation degrees, we estimated the ability of direct anticoagulants to depress the coagulability of recalcified sheep blood using the third international he...

journal_title：Thrombosis research

authors： Drozd NN,Sher AI,Makarov VA,Galbraikh LS,Vikhoreva GA,Gorbachiova IN

更新日期：2001-06-01 00:00:00

abstract：:Several single-nucleotide polymorphisms (SNPs) have been recognized as associated with ischemic heart disease (IHD) although the optimal set of risk genotypes has not be identified. This study aimed to examine whether identified high-risk SNPs are associated with early onset of IHD. In the GENOCOR study, 44 high-risk ...

journal_title：Thrombosis research

authors： Vecoli C,Adlerstein D,Shehi E,Bigazzi F,Sampietro T,Foffa I,Carpeggiani C,L'abbate A,Andreassi MG

更新日期：2014-05-01 00:00:00

abstract：:Beta-thromboglobulin (beta-TG) is a platelet-specific protein present in the alpha-granules and secreted into the surrounding medium on cell activation. The sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) of platelet releasate after inhibition of metalloproteinases with ethyleneglycol-bis-(beta-a...

journal_title：Thrombosis research

authors： Resmi KR,Krishnan LK

更新日期：2002-05-15 00:00:00

abstract：:It has been found in our laboratory that compression induces disaggregation and decompression induces aggregation of human platelets. The experimental design was based on the premise that oppositely charged amino acid residues of fibrinogen are juxtaposed in the specific adhesive site(s). This can be explained by the ...

journal_title：Thrombosis research

authors： Murayama M

更新日期：1987-03-15 00:00:00

abstract：:Heparin and other antithrombotic drugs besides their anticoagulant action could have a profibrinolytic effect. We have analyzed the effect of unfractionated heparin (UFH) and hirudin on PAI-1 gene expression in human umbilical vein endothelial cells (HUVEC). Cells were stimulated with UFH (1 and 10 IU/ml) and hirudin ...

journal_title：Thrombosis research

authors： Orbe J,Montes R,Zabalegui N,Pérez-Ruiz A,Páramo JA

更新日期：1999-05-01 00:00:00

abstract：:beta-Factor XIIa (beta-XIIa, Mr approximately 30,000) was isolated from human plasma by a procedure which utilized, as an initial step, the adsorption of Factor XII to celite. Activation of Factor XII and subsequent release of beta-XIIa was brought about by the proteolytic action of co-adsorbed kallikrein. Two success...

journal_title：Thrombosis research

authors： Tankersley DL,Alving BM,Finlayson JS

更新日期：1982-02-15 00:00:00

abstract：:Factor IX Nagoya 3 (IX Nagoya 3) is a natural mutant of factor IX recognized in a patient with moderately severe hemophilia B. The patient had 0.60 units/ml of factor IX antigen and 2-5% of clotting activity. IX Nagoya 3 was purified from the patient's plasma by immunoaffinity chromatography with an anti-factor IX mon...

journal_title：Thrombosis research

authors： Suehiro K,Miyata T,Takeya H,Takamatsu J,Saito H,Murakawa M,Okamura T,Niho Y,Iwanaga S

更新日期：1990-11-15 00:00:00

abstract：:We studied a Japanese family with type I antithrombin (AT) deficiency and identified a novel in-frame deletion mutation (-ATG at nucleotide position of 2771-2773) in the AT gene, which predicted loss of a methionine (Met) at amino acid number of 103. In addition, we found a single base replacement of G to A at nucleot...

journal_title：Thrombosis research

authors： Katayama K,Hashimoto N,Tanaka Y,Ozawa T,Emi Y,Ikeda T,Katayama M,Nomura S,Kitajima I,Nakano T,Imanaka T

更新日期：2005-01-01 00:00:00

abstract：:Chloroquine inhibited aggregation of rat blood platelets in a dose-dependent way. The inhibitory effect decreased, depending on the aggregation stimulus used, in the rank order of potency: ADP > thrombin > A23187. Effect of 1 millimolar chloroquine on A23187-stimulated aggregation was significantly decreased or comple...

journal_title：Thrombosis research

authors： Jancinová V,Nosál R,Petríková M

更新日期：1994-06-01 00:00:00

abstract：:The effect of the vasopressin analogue DDAVP on Factor VIII in plasma has been extensively studied in humans. To examine the effect of new and potentially better analogues a suitable animal model has to be established. In the present study trained Beagle dogs were injected with DDAVP and the time course of the Factor ...

journal_title：Thrombosis research

authors： Vilhardt H,Barth T,Falch J,Nilsson IM

更新日期：1987-09-01 00:00:00

abstract：INTRODUCTION:To test the hypothesis that the platelet microparticle (PMP) and endothelial microparticle (EMP) may contribute to the hypercoagulability associated with microvascular thrombosis in patients with nontraumatc osteonecrosis of the femoral head (ONFH). MATERIALS AND METHODS:The study comprised 46 patients wh...

journal_title：Thrombosis research

authors： Kang P,Shen B,Yang J,Pei F

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:This study aimed to determine the risk factors for subclinical umbilical catheter-related thrombosis (UCRT) and its association with clinical morbidities. MATERIALS AND METHODS:In infants without any symptoms associated with umbilical catheterization, the presence of thrombosis was monitored using abdomin...

journal_title：Thrombosis research

authors： Hwang JH,Chung ML,Lim YJ

更新日期：2020-10-01 00:00:00

abstract：INTRODUCTION:After major liver surgery, there are risks of both postoperative bleeding and thrombosis. Routine coagulation monitoring is indicated, but may not provide adequate clinical guidance. Thus, we described the clotting status in a pilot study using broader coagulation testing. We analysed the temporal pattern ...

journal_title：Thrombosis research

authors： Dumitrescu G,Januszkiewicz A,Ågren A,Magnusson M,Isaksson B,Wernerman J

更新日期：2015-08-01 00:00:00

abstract：:The behavior of hemostatic system activation during protracted physical exercise is well known, but the duration of its modification is not yet defined. In order to evaluate the time of hemostatic system activation after prolonged strenuous endurance physical exercise (typical marathon race: 42.195 km, v=15.35 km/h; m...

journal_title：Thrombosis research

authors： Prisco D,Paniccia R,Bandinelli B,Fedi S,Cellai AP,Liotta AA,Gatteschi L,Giusti B,Colella A,Abbate R,Gensini GF

更新日期：1998-01-15 00:00:00

abstract：PURPOSE:A poor implementation of VTE prophylactic measures recommended for critically ill patients has been observed in several epidemiological studies. The clinical factors associated with this have not been clearly established. The objective of our study was to identify which factors could be related to the inappropr...

journal_title：Thrombosis research

authors： García-Olivares P,Guerrero JE,Keough E,Galdos P,Carriedo D,Murillo F,Rivera A,PROF-ETEV study investigators.

更新日期：2016-07-01 00:00:00

abstract：:Increased fibrinolytic activity is a well recognized constant finding observed during cardiopulmonary bypass (CPB). The purpose of the present work was to study and estimate the factors involved in the plasminogen activation and prekallikrein-kallikrein systems in a population of adult patients undergoing open heart s...

journal_title：Thrombosis research

authors： Baños G,de la Peña A,Izaguirre R

更新日期：1992-09-01 00:00:00

abstract：:Radioactivity from I125-labeled human platelets was measured to estimate the extent of binding of platelet surface proteins to immobilized thrombin. 1-3% of the radioactivity was bound with 10-20% of this amount apparently irreversibly bound to the thrombin matrix. Site-specific chemical modification of thrombin with ...

journal_title：Thrombosis research

authors： Wu HF,White GC 2nd,Workman EF Jr,Jenzano JW,Lundblad RL

更新日期：1992-08-15 00:00:00

abstract：:Algal fucoidans possess a wide variety of biological activities, including anticoagulation and antithrombosis, making them potential candidates for clinical use. We assessed the antiaggregant, anticoagulant and antithrombotic activities and the underlying mechanism of the low- and high-molecular weight fucoidans from ...

journal_title：Thrombosis research

authors： Zhu Z,Zhang Q,Chen L,Ren S,Xu P,Tang Y,Luo D

更新日期：2010-05-01 00:00:00

abstract：:A new type of assay for heparins has been devised, in which the test material competes with 125I-labelled heparin for binding to protamine-Sepharose. The assay is very sensitive and will measure heparin concentrations down to 10 ng ml-1. It responds to both the degree of sulphation and the molecular weight of acidic p...

journal_title：Thrombosis research

authors： Dawes J,Pepper DS

更新日期：1982-08-15 00:00:00

abstract：:Excess platelets shorten most clotting tests for lupus anticoagulant (LA). Often it is not clear if a shortened, normal or slightly prolonged result in a test masks a weak LA in combination with activated platelets, which express procoagulant phospholipid (PPL). Our aim was to investigate a new LA-insensitive factor X...

journal_title：Thrombosis research

authors： Exner T,Low J

更新日期：2004-01-01 00:00:00

abstract：:To compare Canola a terrestrial (n-3) oil with fish oil (n-3) and common vegetable oil (n-6) in decreasing serum lipids and platelet aggregation, various oils were included in Chow-based diets and fed to rats in an eight-weeks feeding trial. The Chow diet contained 2% cholesterol along with either Canola, menhaden, sa...

journal_title：Thrombosis research

authors： Watkins T,Lenz P,Bierenbaum M

更新日期：1990-08-01 00:00:00

abstract：:Generally, the rules of good practice in transfusion medicine apply also to the pediatric age group. However, the frequency of specific diseases that might necessitate the administration of fresh frozen plasma (FFP) differs from that in adults. Physiologic differences to the later age exist in the neonatal period and ...

journal_title：Thrombosis research

authors： Muntean W

更新日期：2002-10-31 00:00:00

abstract：INTRODUCTION:The safety and efficacy of low-molecular-weight heparin (LMWH) treatment in patients with cancer-associated thrombosis (CAT) beyond 6months are unknown. Our aim was to determine the safety of long-term tinzaparin use in patients with CAT. METHODS:We performed a prospective, open, single arm, multicentre s...

journal_title：Thrombosis research

authors： Jara-Palomares L,Solier-Lopez A,Elias-Hernandez T,Asensio-Cruz M,Blasco-Esquivias I,Marin-Barrera L,de la Borbolla-Artacho MR,Praena-Fernandez JM,Montero-Romero E,Navarro-Herrero S,Serrano-Gotarredona MP,Sánchez-Díaz JM,Palacios

更新日期：2017-09-01 00:00:00

abstract：:ZK-807834 (also known as CI-1031) is a small molecule that potently and selectively inhibits Factor Xa. Studies in animals have shown that ZK-807834 attenuates thrombosis and thrombus progression after fibrinolysis and exhibits an increased antithrombotic-to-bleeding risk ratio compared with conventional agents. The p...

journal_title：Thrombosis research

authors： Post JM,Sullivan ME,Abendschein D,Ewing J,Hinchman JW,Light DR

更新日期：2002-02-15 00:00:00

abstract：BACKGROUND:It is well demonstrated that obesity is an independent risk factor for cardiovascular diseases. Recent studies have shown that obesity, insulin resistance and atherosclerosis are closely related phenomena in which low-grade inflammatory state and prothrombotic condition has pivotal roles. It has been shown t...

journal_title：Thrombosis research

authors： Guldiken S,Demir M,Arikan E,Turgut B,Azcan S,Gerenli M,Tugrul A

更新日期：2007-01-01 00:00:00

abstract：INTRODUCTION:We conducted this prospective study in order to investigate the hypotheses that an alternative pathway for fibrinolysis is activated in patients who have undergone cardiopulmonary bypass (CPB) surgery and major abdominal surgery and that the levels of fibrin degradation products digested by polymorphonucle...

journal_title：Thrombosis research

authors： Gando S,Kameue T,Sawamura A,Hayakawa M,Hoshino H,Kubota N

更新日期：2007-01-01 00:00:00