Abstract：
:We studied hepatic mitochondria to determine the effects of ethanol in vitro and of chronic ethanol consumption on the temperature dependence (10 degrees-45 degrees C) of a) substrate oxidation, and b) ATP hydrolysis, with or without CCCP. Arrhenius plots showed the characteristic breaks around 20 degrees C both for electron transport and ATP hydrolysis with high energy of activation at low temperature and low energy of activation at high temperature. Ethanol, in vitro, generally lowered the energy of activation at high temperature and shifted the break in the Arrhenius plots to lower temperatures suggesting an increase in membrane fluidity. At 40 degrees C and above ethanol accelerated electron transport and greatly stimulated ATPase activity. In mitochondria from ethanol-fed rats, Arrhenius plots showed a shift in the breaks to a higher temperature, a finding which suggests a change in membrane structure, possibly associated with decreased fluidity. This may be an adaption of the mitochondrial membranes to counter the effect of ethanol on membrane structure.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Rottenberg H,Robertson DE,Rubin Edoi
10.1007/978-1-4757-1419-7_34subject
Has Abstractpub_date
1980-01-01 00:00:00pages
345-53eissn
0065-2598issn
2214-8019journal_volume
132pub_type
杂志文章abstract：:Natural focal diseases are caused by biological agents associated with specific landscapes. The natural focus of such diseases is defined as any natural ecosystem containing the pathogen's population as an essential component. In such context, the agent circulates independently on human presence, and humans may become...
journal_title：Advances in experimental medicine and biology
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更新日期：2017-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
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pub_type： 杂志文章
doi：10.1007/978-1-4939-2981-8_83
更新日期：2016-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
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journal_title：Advances in experimental medicine and biology
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更新日期：2010-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
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journal_title：Advances in experimental medicine and biology
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4613-2165-1_19
更新日期：1985-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：
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journal_title：Advances in experimental medicine and biology
pub_type： 临床试验,杂志文章
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journal_title：Advances in experimental medicine and biology
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journal_title：Advances in experimental medicine and biology
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更新日期：2015-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
pub_type： 临床试验,杂志文章
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
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更新日期：1998-01-01 00:00:00
abstract：:Mast cells play a major role in allergy and anaphylaxis, as well as a protective role in immunity against bacteria and venoms (innate immunity) and T-cell activation (acquired immunity).1,2 It was long thought that two steps are essential to mast cell activation. The first step (sensitization) occurs when antigen-spec...
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pub_type： 杂志文章,评审
doi：10.1007/978-1-4419-9533-9_3
更新日期：2011-01-01 00:00:00
