Abstract:
:In a retrospective series of 45 patients with uterine cervix carcinoma Stage Ib and IIa who had been treated by radiation, biopsy material obtained prior to treatment was reevaluated for the presence of lymphocytic infiltration. The analysis based on 5 degrees of the intensity of stromal reaction has shown that the presence of lymphocytic infiltration, the intensity of which was significantly related to the proportion of blood vessels in stroma, was connected with a favorable outcome of treatment. The results suggest that vascular density being the determinant factor in oxygenation of the cancer tissue and its radiotherapeutic control may also play an important role in the immunological reaction against the tumor.
journal_name
Neoplasmajournal_title
Neoplasmaauthors
Boljesíková E,Siracká E,Kubovcáková N,Gyarfásová Msubject
Has Abstractpub_date
1984-01-01 00:00:00pages
479-84issue
4eissn
0028-2685issn
1338-4317journal_volume
31pub_type
杂志文章相关文献
NEOPLASMA文献大全abstract::Transcription factor 21 (TCF21) has been identified as a candidate tumor suppressor at 6q23-q24 that is epigenetically inactivated in many types of human cancers. We recently found that TCF21 methylation level was significantly increased in clear cell renal cell carcinoma (ccRCC). The purpose of this study was to inve...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2012_076
更新日期:2012-01-01 00:00:00
abstract::Solid phase radioimmunoassay for detection of anti-BLV antibodies in sera of infected animals is described. Viral antigens bound to surface of polystyrene are able selectively adsorb the antibodies from serum. Detection of bound antibodies quantitatively was done by 125I-labeled protein A from Staphylococcus aureus. T...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1981-01-01 00:00:00
abstract::Tumor necrosis factor-alpha (TNF-alpha) a proinflammatory cytokine with multiple actions was first identified for its anticancer activity. However, TNF-alpha has a beneficial function in activation of host defense, its uncontrolled production can lead to pathological consequences. At the cellular level, it is able to ...
journal_title:Neoplasma
pub_type: 杂志文章,评审
doi:
更新日期:1999-01-01 00:00:00
abstract::During the last 30 years the trends in cancer mortality in Europe significantly changed. In 1970 the male and female cancer mortality (all ages) was higher in the Western Europe than in the "socialist" Central and Eastern Europe. After 1970 in most Western countries decrease or no change of male premature (0-64 years)...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:2000-01-01 00:00:00
abstract::Antisera against tumor-associated and organ-specific antigens of human mammary glands, as well as mammary carcinoma patient sera were used in cross-reactions with the test-system for a nucleoid antigen of Hep-2 retravirus. None of the antigens, revealed in mammary carcinomas and human milk seems to be either viral str...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1977-01-01 00:00:00
abstract::The effects of first-line chemotherapy on overall survival (OS) might be confounded by subsequent therapies in patients with non-small cell lung cancer (NSCLC). We examined whether progression-free survival (PFS), post-progression survival (PPS), or tumor response could be valid surrogate endpoints for OS after first-...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2014_030
更新日期:2014-01-01 00:00:00
abstract::The authors have studied the influence of two kinds of transplantable melanomas on the secretion of oncostatin M (OSM) and total proteins by peritoneal macrophages. Culture supernatant samples were tested by ELISA. The macrophages of melanoma-bearing animals released a lower amount of OSM than those of the controls. A...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract::Tamoxifen belongs among relatively new drugs. As it has already been shown, it undoubtedly brings a benefit to oncology patients. However, there are still questions regarding its broader use in therapy or cancer prevention. This review puts together some data available at present time with the aim of elucidating the m...
journal_title:Neoplasma
pub_type: 杂志文章,评审
doi:
更新日期:2000-01-01 00:00:00
abstract::This study comprises 46 patients with various stages of breast carcinoma and 49 normal women as control group. Serum xanthine oxidase and uric acid levels were determined. Assessment in terms of changes of the enzyme xanthine oxidase was carried out prior and after surgery as a short term follow up. There was a signif...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1980-01-01 00:00:00
abstract::Treatment with interferon-alpha (IFNalpha) prolongs survival in chronic myeloid leukemia (CML). Additionally, cytarabine (AraC) can reduce the number of Ph + metaphases. Fortythree previously untreated patients with CML in chronic phase were randomly assigned to receive either. IFNalpha 2b (5 MU sqm/daily) or IFNalpha...
journal_title:Neoplasma
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:
更新日期:2000-01-01 00:00:00
abstract::This paper deals with determination of potential carcinogenic and inhibitory activity of 10 compounds isolated from the ethanolic extract of Lilium candidum L. perfonned by DC polarography. The series of investigated compounds consisted of two spirostanol saponins, two pyroline derivatives, jatropham and its glucoside...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:2000-01-01 00:00:00
abstract::Hypoxia is one of the basic characteristics of the colorectal cancer and HIF1 plays a central role in tumor hypoxia adaptation and controls the expression of a variety of genes. But it had not reached a comprehensive understanding of them in colorectal cancer in hypoxia. This study silenced HIF1-alpha, which is the re...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2010_04_299
更新日期:2010-01-01 00:00:00
abstract::Dendritic cells are able to induce anti-tumor immune responses by presenting tumor-specific antigens to T-lymphocytes. Various tumor-associated antigens have been studied in multiple myeloma in an effort to find a strong antigen capable of generating clinically meaningful responses in vaccinated patients. The aim of o...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2010_05_455
更新日期:2010-01-01 00:00:00
abstract::DNA-mediated introduction of genes into mammalian cells promises to be a powerful method for detecting sequences that control cell growth, confer resistance to toxic drugs, code for surface receptor proteins, or, indeed alter cell phenotype in any clearly defined way. The identification and molecular cloning of human ...
journal_title:Neoplasma
pub_type: 杂志文章,评审
doi:
更新日期:1995-01-01 00:00:00
abstract::The influence of hypothyroidism on AFB1 carcinogenesis in inbred Wistar rats was studied. The primary AFB1 hepatocarcinogenesis was significantly delayed and reduced. The transplantable hepatomas showed prolonged latency periods in rats of both sexes, and in males decreased tumor weights and a lower number of lung met...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract::This study is intended to investigate the role of Tripartite Motif (TRIM) 31 in glioma. Immunohistochemistry and western blot analysis showed that TRIM31 was overexpressed in high-grade glioma tissues. Univariate survival analysis indicated that high expression of TRIM31 was related to short survival time of glioma pa...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2019_190106N21
更新日期:2019-09-01 00:00:00
abstract::A combination of chemotherapy with a "second-look" operation has its place in a long-tern treatment of ovarian cancer of stage III, though it will hardly improve the long-term results--the 5-year survival in this stage. Ocassionally, this combination may prove useful and even decisive for prolonging life and even brin...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1977-01-01 00:00:00
abstract::Active human serum manifests a tumoricide effect against cells of the Ehrlich ascites tumor. Sera of patients with Ca ventriculi show a higher effect than those of patients with a chronic streptococcal disorder, in comparison with intact subjects. This tumorcide effect is depressed by Varidase, the degree of depressio...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1975-01-01 00:00:00
abstract::Recent studies have shown an indirect link between platelet count and blood vessel metastasis, but this association with lymphatic vessels metastasis has not been established in NSCLC. So we investigated whether an association exists between preoperative platelet count and lymph node metastasis in NSCLC patients. Betw...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2013_027
更新日期:2013-01-01 00:00:00
abstract::Regional lymph nodes in 80 cases of gastric and 70 cases of breast cancer have been examined and the reactive types have been correlated to the survival periods of the patients. In both groups of patients, a prognostically favorable sign was the detection of lymphocytic predominance combined with sinus histiocytosis, ...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1982-01-01 00:00:00
abstract::Photodynamic therapy (PDT) has been developed in recent years as a new modality for the treatment of various neoplastic and non-neoplastic lesions. Although the method of combining light with photosensitizers for treatment has been around for a century, further understanding has been evolved over the past decades. The...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:2008-01-01 00:00:00
abstract::This study aimed to investigate the effects of RhoGDIα knockdown on apoptosis and the chemosensitivity of lung cancer cells to paclitaxel. The signaling proteins involved were also assessed. RhoGDIα expression was assessed by RT-PCR, Western blotting and immunohistochemistry. Apoptosis was determined by flow cytometri...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2012_070
更新日期:2012-01-01 00:00:00
abstract::Serum concentration of alpha1-proteinase inhibitor (alpha1-PI) was determined by nephelometric method in forty seven patients with liver cirrhosis (LC) and fifteen patients with hepatocellular carcinoma (HCC). Our data show an increase in the concentration of alpha1-PI in the group with decompensated LC by 17% and in ...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract::Carcinoma of oral cavity have a high risk of recurrence after initial treatment with surgery, radiotherapy, surgery with adjuvant radiotherapy, or radio-chemotherapy.The present study investigated the changes in expression, activity and regulation of matrix metalloproteinases (MMP) -2 and -9 in oral squamous cell carc...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2014_091
更新日期:2014-01-01 00:00:00
abstract::The possible association between cigarette smoking and the risk of benign breast disease (BBD) was assessed in a case-control study conducted in Gdańsk, Poland, between 1990 and 1994. The study compared 160 women with newly diagnosed BBD admitted to the Gdańsk Cancer Outpatients Clinic and 160 controls, women from out...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
abstract::Breast cancer is one of the leading causes of cancer death in women. The Notch family of proteins plays crucial roles in determining cell fates such as proliferation, differentiation and apoptosis. A role for Notch signaling in human breast cancer has been suggested by the development of adenocarcinomas in the murine ...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
abstract::Age over 65 years is a risk factor per se for doxorubicin administration, and coexisting diseases pose additional problems. There is still controversy whether chemotherapy regimens for elderly patients with aggressive NHL should be full-dose doxorubicin containing or whether development of non-anthracycline containing...
journal_title:Neoplasma
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1999-01-01 00:00:00
abstract::Liver cancer is the sixth most prevalent cancer worldwide and the third leading cause of cancer-related deaths. Adriamycin (ADR) resistance, which often leads to the progression of malignant tumors, is a major treatment obstacle for liver cancer. It has been confirmed that miR-155-5p could reverse drug resistance in h...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2020_200106N17
更新日期:2021-01-01 00:00:00
abstract::Cisplatin-based chemotherapy is highly effective in advanced seminoma, but at the cost of a considerable toxicity. The response rate of carboplatin is comparable with cisplatin combinations but the relapse rate is higher. Our study assesses the efficacy and the toxicity of the combination of carboplatin and cyclophosp...
journal_title:Neoplasma
pub_type: 临床试验,杂志文章
doi:
更新日期:2000-01-01 00:00:00
abstract::A series of seven monoclonal antibodies recognizing cell surface antigens of similar distribution on a panel of leukemia/lymphoma and lymphoblastoid human cell lines was prepared by hybridoma technique after immunization with non-T, non-B acute lymphoblastic leukemia cell line REH. Immune reactivity of these monoclona...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1985-01-01 00:00:00