Prognostic significance of lymphocytic infiltration in radiation-treated uterine cervix carcinoma.

Abstract:

:In a retrospective series of 45 patients with uterine cervix carcinoma Stage Ib and IIa who had been treated by radiation, biopsy material obtained prior to treatment was reevaluated for the presence of lymphocytic infiltration. The analysis based on 5 degrees of the intensity of stromal reaction has shown that the presence of lymphocytic infiltration, the intensity of which was significantly related to the proportion of blood vessels in stroma, was connected with a favorable outcome of treatment. The results suggest that vascular density being the determinant factor in oxygenation of the cancer tissue and its radiotherapeutic control may also play an important role in the immunological reaction against the tumor.

journal_name

Neoplasma

journal_title

Neoplasma

authors

Boljesíková E,Siracká E,Kubovcáková N,Gyarfásová M

subject

Has Abstract

pub_date

1984-01-01 00:00:00

pages

479-84

issue

4

eissn

0028-2685

issn

1338-4317

journal_volume

31

pub_type

杂志文章
  • Down-regulation of TCF21 is associated with poor survival in clear cell renal cell carcinoma.

    abstract::Transcription factor 21 (TCF21) has been identified as a candidate tumor suppressor at 6q23-q24 that is epigenetically inactivated in many types of human cancers. We recently found that TCF21 methylation level was significantly increased in clear cell renal cell carcinoma (ccRCC). The purpose of this study was to inve...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2012_076

    authors: Ye YW,Jiang ZM,Li WH,Li ZS,Han YH,Sun L,Wang Y,Xie J,Liu YC,Zhao J,Tang AF,Li XX,Guan ZC,Gui YT,Cai ZM

    更新日期:2012-01-01 00:00:00

  • Diagnosis of bovine leukosis virus infection by solid phase radioimmunoassay for virus antibody.

    abstract::Solid phase radioimmunoassay for detection of anti-BLV antibodies in sera of infected animals is described. Viral antigens bound to surface of polystyrene are able selectively adsorb the antibodies from serum. Detection of bound antibodies quantitatively was done by 125I-labeled protein A from Staphylococcus aureus. T...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Zajac V,Altaner C

    更新日期:1981-01-01 00:00:00

  • Tumor necrosis factor-alpha: molecular-biological aspects minireview.

    abstract::Tumor necrosis factor-alpha (TNF-alpha) a proinflammatory cytokine with multiple actions was first identified for its anticancer activity. However, TNF-alpha has a beneficial function in activation of host defense, its uncontrolled production can lead to pathological consequences. At the cellular level, it is able to ...

    journal_title:Neoplasma

    pub_type: 杂志文章,评审

    doi:

    authors: Szatmáry Z

    更新日期:1999-01-01 00:00:00

  • Recent trends in cancer mortality in the Slovak Republic and in Europe.

    abstract::During the last 30 years the trends in cancer mortality in Europe significantly changed. In 1970 the male and female cancer mortality (all ages) was higher in the Western Europe than in the "socialist" Central and Eastern Europe. After 1970 in most Western countries decrease or no change of male premature (0-64 years)...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Ginter E

    更新日期:2000-01-01 00:00:00

  • Human mammary gland associated antigens. Lack of D-type retravirus-induced antigens.

    abstract::Antisera against tumor-associated and organ-specific antigens of human mammary glands, as well as mammary carcinoma patient sera were used in cross-reactions with the test-system for a nucleoid antigen of Hep-2 retravirus. None of the antigens, revealed in mammary carcinomas and human milk seems to be either viral str...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Kryukova IN,Bobrova TS

    更新日期:1977-01-01 00:00:00

  • Individual-level data on the relationships of progression-free survival, post-progression survival, and tumor response with overall survival in patients with advanced non-squamous non-small cell lung cancer.

    abstract::The effects of first-line chemotherapy on overall survival (OS) might be confounded by subsequent therapies in patients with non-small cell lung cancer (NSCLC). We examined whether progression-free survival (PFS), post-progression survival (PPS), or tumor response could be valid surrogate endpoints for OS after first-...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2014_030

    authors: Imai H,Takahashi T,Mori K,Ono A,Akamatsu H,Shukuya T,Taira T,Kenmotsu H,Naito T,Murakami H,Endo M,Nakajima T,Yamamoto N

    更新日期:2014-01-01 00:00:00

  • Estimation of oncostatin M (OSM) secretion by peritoneal macrophages with regard to the progression of transplantable melanomas.

    abstract::The authors have studied the influence of two kinds of transplantable melanomas on the secretion of oncostatin M (OSM) and total proteins by peritoneal macrophages. Culture supernatant samples were tested by ELISA. The macrophages of melanoma-bearing animals released a lower amount of OSM than those of the controls. A...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Kozłowska K,Cichorek M,Zarzeczna M

    更新日期:1998-01-01 00:00:00

  • Tamoxifen in cancer therapy: minireview.

    abstract::Tamoxifen belongs among relatively new drugs. As it has already been shown, it undoubtedly brings a benefit to oncology patients. However, there are still questions regarding its broader use in therapy or cancer prevention. This review puts together some data available at present time with the aim of elucidating the m...

    journal_title:Neoplasma

    pub_type: 杂志文章,评审

    doi:

    authors: Novotny L,Rauko P,Vachálková A,Peterson-Biggs M

    更新日期:2000-01-01 00:00:00

  • Serum xanthine oxidase in breast carcinoma.

    abstract::This study comprises 46 patients with various stages of breast carcinoma and 49 normal women as control group. Serum xanthine oxidase and uric acid levels were determined. Assessment in terms of changes of the enzyme xanthine oxidase was carried out prior and after surgery as a short term follow up. There was a signif...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Alsabti E

    更新日期:1980-01-01 00:00:00

  • Hematological and cytogenetic response of interferon alpha 2b alone and combined interferon alpha plus cytarabine as a first-line treatment in chronic myeloid leukemia.

    abstract::Treatment with interferon-alpha (IFNalpha) prolongs survival in chronic myeloid leukemia (CML). Additionally, cytarabine (AraC) can reduce the number of Ph + metaphases. Fortythree previously untreated patients with CML in chronic phase were randomly assigned to receive either. IFNalpha 2b (5 MU sqm/daily) or IFNalpha...

    journal_title:Neoplasma

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:

    authors: Tóthová E,Fricová M,Kafková A,Stecová N,Guman T,Raffac S,Hlebasková M

    更新日期:2000-01-01 00:00:00

  • Potential carcinogenic and inhibitory activity of compounds isolated from Lilium candidum L.

    abstract::This paper deals with determination of potential carcinogenic and inhibitory activity of 10 compounds isolated from the ethanolic extract of Lilium candidum L. perfonned by DC polarography. The series of investigated compounds consisted of two spirostanol saponins, two pyroline derivatives, jatropham and its glucoside...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Vachálková A,Eisenreichová E,Haladová M,Mucaji P,Józová B,Novotný L

    更新日期:2000-01-01 00:00:00

  • Identification of differential proteins in colon cancer SW480 cells with HIF1-alpha silence by proteome analysis.

    abstract::Hypoxia is one of the basic characteristics of the colorectal cancer and HIF1 plays a central role in tumor hypoxia adaptation and controls the expression of a variety of genes. But it had not reached a comprehensive understanding of them in colorectal cancer in hypoxia. This study silenced HIF1-alpha, which is the re...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2010_04_299

    authors: Wu XY,Fu ZX,Wang XH,Shen W

    更新日期:2010-01-01 00:00:00

  • Generation of myeloma-specific T cells using dendritic cells loaded with MUC1- and hTERT- drived nonapeptides or myeloma cell apoptotic bodies.

    abstract::Dendritic cells are able to induce anti-tumor immune responses by presenting tumor-specific antigens to T-lymphocytes. Various tumor-associated antigens have been studied in multiple myeloma in an effort to find a strong antigen capable of generating clinically meaningful responses in vaccinated patients. The aim of o...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2010_05_455

    authors: Ocadlikova D,Kryukov F,Mollova K,Kovarova L,Buresdova I,Matejkova E,Penka M,Buchler T,Hajek R,Michalek J

    更新日期:2010-01-01 00:00:00

  • DNA-mediated gene transfer into mammalian cells and cancer.

    abstract::DNA-mediated introduction of genes into mammalian cells promises to be a powerful method for detecting sequences that control cell growth, confer resistance to toxic drugs, code for surface receptor proteins, or, indeed alter cell phenotype in any clearly defined way. The identification and molecular cloning of human ...

    journal_title:Neoplasma

    pub_type: 杂志文章,评审

    doi:

    authors: Sláviková K,Massouridou E

    更新日期:1995-01-01 00:00:00

  • Primary and transplantable hepatomas induced by aflatoxin B1 in hypothyroid rats.

    abstract::The influence of hypothyroidism on AFB1 carcinogenesis in inbred Wistar rats was studied. The primary AFB1 hepatocarcinogenesis was significantly delayed and reduced. The transplantable hepatomas showed prolonged latency periods in rats of both sexes, and in males decreased tumor weights and a lower number of lung met...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Bednarz W

    更新日期:1989-01-01 00:00:00

  • TRIM31 promotes proliferation, invasion and migration of glioma cells through Akt signaling pathway.

    abstract::This study is intended to investigate the role of Tripartite Motif (TRIM) 31 in glioma. Immunohistochemistry and western blot analysis showed that TRIM31 was overexpressed in high-grade glioma tissues. Univariate survival analysis indicated that high expression of TRIM31 was related to short survival time of glioma pa...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2019_190106N21

    authors: Shi G,Lv C,Yang Z,Qin T,Sun L,Pan P,Wang D

    更新日期:2019-09-01 00:00:00

  • Chemotherapy and "second-look" procedure in the treatment of ovarian carcinoma.

    abstract::A combination of chemotherapy with a "second-look" operation has its place in a long-tern treatment of ovarian cancer of stage III, though it will hardly improve the long-term results--the 5-year survival in this stage. Ocassionally, this combination may prove useful and even decisive for prolonging life and even brin...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Manka I,Belohorský B

    更新日期:1977-01-01 00:00:00

  • Lowering of the tumoricide activity of human serum with Varidase. II. Antibodies against Varidase in human serum measured by complement binding.

    abstract::Active human serum manifests a tumoricide effect against cells of the Ehrlich ascites tumor. Sera of patients with Ca ventriculi show a higher effect than those of patients with a chronic streptococcal disorder, in comparison with intact subjects. This tumorcide effect is depressed by Varidase, the degree of depressio...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Mikolásek J

    更新日期:1975-01-01 00:00:00

  • Preoperative platelet count in predicting lymph node metastasis and prognosis in patients with non-small cell lung cancer.

    abstract::Recent studies have shown an indirect link between platelet count and blood vessel metastasis, but this association with lymphatic vessels metastasis has not been established in NSCLC. So we investigated whether an association exists between preoperative platelet count and lymph node metastasis in NSCLC patients. Betw...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2013_027

    authors: Liu HB,Gu XL,Ma XQ,Lv TF,Wu Y,Xiao YY,Yuan DM,Li YF,Song Y

    更新日期:2013-01-01 00:00:00

  • Prognostic significance of reactive changes in regional lymph nodes in gastric and mammary carcinomas.

    abstract::Regional lymph nodes in 80 cases of gastric and 70 cases of breast cancer have been examined and the reactive types have been correlated to the survival periods of the patients. In both groups of patients, a prognostically favorable sign was the detection of lymphocytic predominance combined with sinus histiocytosis, ...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Riegrová D,Jansa P

    更新日期:1982-01-01 00:00:00

  • Comparison of photodynamic therapy with phthalocyanine and photofrin in human colorectal carcinoma.

    abstract::Photodynamic therapy (PDT) has been developed in recent years as a new modality for the treatment of various neoplastic and non-neoplastic lesions. Although the method of combining light with photosensitizers for treatment has been around for a century, further understanding has been evolved over the past decades. The...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Stukavec J,Horak L,Duchac V,Jirasek T,Rakusan J,Karaskova M,Pouckova P

    更新日期:2008-01-01 00:00:00

  • Knockdown of RhoGDIα induces apoptosis and increases lung cancer cell chemosensitivity to paclitaxel.

    abstract::This study aimed to investigate the effects of RhoGDIα knockdown on apoptosis and the chemosensitivity of lung cancer cells to paclitaxel. The signaling proteins involved were also assessed. RhoGDIα expression was assessed by RT-PCR, Western blotting and immunohistochemistry. Apoptosis was determined by flow cytometri...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2012_070

    authors: Rong F,Li W,Chen K,Li DM,Duan WM,Feng YZ,Li F,Zhou XW,Fan SJ,Liu Y,Tao M

    更新日期:2012-01-01 00:00:00

  • Does the concentration of alpha 1-proteinase inhibitor reflect the transformation of liver cirrhosis to liver carcinoma?

    abstract::Serum concentration of alpha1-proteinase inhibitor (alpha1-PI) was determined by nephelometric method in forty seven patients with liver cirrhosis (LC) and fifteen patients with hepatocellular carcinoma (HCC). Our data show an increase in the concentration of alpha1-PI in the group with decompensated LC by 17% and in ...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Dabrowska M,Mantur M,Panasiuk A,Prokopowicz J

    更新日期:1997-01-01 00:00:00

  • MMP-9 as a potential biomarker for carcinoma of oral cavity: a study in eastern India.

    abstract::Carcinoma of oral cavity have a high risk of recurrence after initial treatment with surgery, radiotherapy, surgery with adjuvant radiotherapy, or radio-chemotherapy.The present study investigated the changes in expression, activity and regulation of matrix metalloproteinases (MMP) -2 and -9 in oral squamous cell carc...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2014_091

    authors: Nanda DP,Dutta K,Ganguly KK,Hajra S,Mandal SS,Biswas J,Sinha D

    更新日期:2014-01-01 00:00:00

  • Smoking habit and benign breast disease.

    abstract::The possible association between cigarette smoking and the risk of benign breast disease (BBD) was assessed in a case-control study conducted in Gdańsk, Poland, between 1990 and 1994. The study compared 160 women with newly diagnosed BBD admitted to the Gdańsk Cancer Outpatients Clinic and 160 controls, women from out...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Dziewulska-Bokiniec A

    更新日期:1995-01-01 00:00:00

  • A study on Notch signaling in human breast cancer.

    abstract::Breast cancer is one of the leading causes of cancer death in women. The Notch family of proteins plays crucial roles in determining cell fates such as proliferation, differentiation and apoptosis. A role for Notch signaling in human breast cancer has been suggested by the development of adenocarcinomas in the murine ...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Zang S,Ji Ch,Qu X,Dong X,Ma D,Ye J,Ma R,Dai J,Guo D

    更新日期:2007-01-01 00:00:00

  • Comparison of two non-anthracycline-containing regimens for elderly patients with diffuse large-cell non Hodgkin's lymphoma--possible pitfalls in results reporting and interpretation.

    abstract::Age over 65 years is a risk factor per se for doxorubicin administration, and coexisting diseases pose additional problems. There is still controversy whether chemotherapy regimens for elderly patients with aggressive NHL should be full-dose doxorubicin containing or whether development of non-anthracycline containing...

    journal_title:Neoplasma

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Jelić S,Milanović N,Tomasević Z,Matković S,Gavrilović D

    更新日期:1999-01-01 00:00:00

  • miR-155-5p increases the sensitivity of liver cancer cells to adriamycin by regulating ATG5-mediated autophagy.

    abstract::Liver cancer is the sixth most prevalent cancer worldwide and the third leading cause of cancer-related deaths. Adriamycin (ADR) resistance, which often leads to the progression of malignant tumors, is a major treatment obstacle for liver cancer. It has been confirmed that miR-155-5p could reverse drug resistance in h...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2020_200106N17

    authors: Yu Q,Xu XP,Yin XM,Peng XQ

    更新日期:2021-01-01 00:00:00

  • Carboplatin and cyclophosphamide in the treatment of metastatic seminoma.

    abstract::Cisplatin-based chemotherapy is highly effective in advanced seminoma, but at the cost of a considerable toxicity. The response rate of carboplatin is comparable with cisplatin combinations but the relapse rate is higher. Our study assesses the efficacy and the toxicity of the combination of carboplatin and cyclophosp...

    journal_title:Neoplasma

    pub_type: 临床试验,杂志文章

    doi:

    authors: Mardiak J,Sálek T,Sycova-Milá Z,Sufliarsky J,Baláz M,Koza I

    更新日期:2000-01-01 00:00:00

  • Monoclonal antibodies against MHC class II antigens elicited with a human non-T, non-B acute lymphoblastic leukemia cell line.

    abstract::A series of seven monoclonal antibodies recognizing cell surface antigens of similar distribution on a panel of leukemia/lymphoma and lymphoblastoid human cell lines was prepared by hybridoma technique after immunization with non-T, non-B acute lymphoblastic leukemia cell line REH. Immune reactivity of these monoclona...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Poláková K,Chorváth B,Sedlák J,Duraj J,Matoska J,Karpatová M

    更新日期:1985-01-01 00:00:00