Abstract:
:This study determines the inotropic effects of prostaglandin D2 (PGD2) and prostaglandin E1 (PGE1) in the isolated, arterial perfused newborn (NB) and adult (A) rabbit heart. Significant positive inotropism of PGD2 was observed at all concentrations studied (1 X 10(-17) to 1 X 10(-7) M) in the two age groups; the effect in the NB was significantly greater (p less than 0.05) than that in the A at PGD2 concentrations higher than 1 X 10(-17) M. Significant positive inotropism of PGE1 was observed at PGE1 concentrations higher than 1 X 10(-8) M in the NB, and only at 1 X 10(-6) M in the A. In the NB, the relaxation parameters [1/2 RT and the ratio of +dT/dt (max) to -dT/dt (max)] decreased to 80% of control after PGE1 infusion, but not after PGD2 infusion. In contrast, relaxation parameters in the A were not different from control. Propranolol (1 X 10(-6) M) did not alter the positive inotropic action of PGD2 and PGE1 in the NB. These data indicate that: 1) the positive inotropic effects of PGD2 and PGE1 in NB are greater than that in the A, 2) PGE1 and not PGD2, enhances myocardial relaxation only in the NB, 3) the contractile effects of PGD2 and PGE1 are not mediated by beta-receptors.
journal_name
Pediatr Resjournal_title
Pediatric researchauthors
Uemura S,Nakanishi T,Matsuoka S,Friedman WF,Jarmakani JMdoi
10.1203/00006450-198412000-00010subject
Has Abstractpub_date
1984-12-01 00:00:00pages
1277-81issue
12eissn
0031-3998issn
1530-0447journal_volume
18pub_type
杂志文章abstract::The zeta subunit of the CD3 T-cell receptor complex and the major histocompatibility complex class 1 (MHC-I) are important not only for the immune response to antigens, they also function as signal molecules in the brain, where they play a role in the postnatal maturation process. The expression of these molecules can...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/01.pdr.0000238246.74817.a0
更新日期:2006-10-01 00:00:00
abstract::Simultaneous measurements of serum immunoreactive thyrocalcitonin (iTCT), immunoreactive parathyroid hormone (iPTH), calcium, inorganic phosphate, magnesium, and alkaline phosphatase were made in 37 normal children whose ages ranged from 6-12 years. Between the ages of 6 and 12 there is a statistically significant ris...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-197702000-00006
更新日期:1977-02-01 00:00:00
abstract::In view of the suggested relationship between substrate availability, fetal growth and circulating fetal IGF-I concentrations, we investigated the effect of maternal starvation on plasma IGF-I levels in the late gestation ovine fetus. Ten fetuses aged 125-130 d gestation were sampled daily from indwelling arterial cat...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-199004000-00015
更新日期:1990-04-01 00:00:00
abstract:BACKGROUND:Genotyping tests were developed to attenuate the impact of viral resistance. Information about the efficacy in genotype base antiretroviral therapy in children is rare and even more in low- and middle-income countries. METHODS:Sixteen children with antiretroviral therapy (ART) failure and triple-class drug-...
journal_title:Pediatric research
pub_type: 杂志文章,多中心研究
doi:10.1038/pr.2016.53
更新日期:2016-07-01 00:00:00
abstract::Antibodies of restricted specificity have been identified in the human in response to certain antigens. The present study analyzed tetanus and diphtheria antitoxins isolated from selected human sera and suggested a restricted response in antibody production to each of these antigens. Purified antibodies from eight ser...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-197712000-00009
更新日期:1977-12-01 00:00:00
abstract::A male child presented on the first day of life with metabolic acidosis with elevated blood lactate (15 mM), pyruvate (0.4 mM), and free fatty acid (1.3 mM) levels and a blood pH of 7.16. The severity of the acidosis was diminished by intravenous administration of glucose in large doses and by bicarbonate. On two occa...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-197512000-00015
更新日期:1975-12-01 00:00:00
abstract:BACKGROUND:Following our clinical observation of tonic responses in response to the knee jerk in infants at very high risk for cerebral palsy (VHR infants), we systematically studied tonic responses, clonus, and reflex irradiation. We questioned (i) whether these responses occurred more often in VHR infants than in typ...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1038/pr.2016.99
更新日期:2016-09-01 00:00:00
abstract::Human milk was fractionated to obtain a partially purified growth factor preparation. The growth factor in this fraction, designated as human milk growth factor III, exhibits chromatographic and biological characteristics similar to epidermal growth factor-urogastrone. Pretreatment of mice with human milk growth facto...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-198509000-00009
更新日期:1985-09-01 00:00:00
abstract::We determined whether closing the ductus arteriosus of the fetal lamb several d before birth would cause persistent pulmonary hypertension after birth. Six experimental fetuses who had their ductus arteriosus ligated 3-17 d before delivery, three control fetuses who had sham ligation of the ductus arteriosus 14 d befo...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-198903000-00005
更新日期:1989-03-01 00:00:00
abstract::Cerebral blood flow (CBF) measurement by near infrared spectroscopy (NIRS) using oxyhemoglobin (HbO2) as a tracer (CBF-HbO2) needs rapid changes in arterial oxygen saturation (SaO2) which often cannot be achieved in many sick infants. An alternative method based on the same adaptation of the Fick principle using i.v. ...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-199801000-00006
更新日期:1998-01-01 00:00:00
abstract::To investigate the difference in ventilatory response to exercise between children and young adults, we administered a treadmill progressive exercise test to seven boys (aged 8 to 11 y [group A]) and six male young adults (aged 14 to 21 y [group B]), who had a history of Kawasaki disease without significant coronary a...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-199903000-00017
更新日期:1999-03-01 00:00:00
abstract::This paper has been retracted at the request of the authors. ...
journal_title:Pediatric research
pub_type: 杂志文章,撤回出版物
doi:10.1038/s41390-019-0529-y
更新日期:2019-11-01 00:00:00
abstract::The regionalization of pediatric services has resulted in differential access to care, sometimes creating barriers to those living in underserved, rural communities. These disparities in access contribute to inferior healthcare outcomes among infants and children. We review the medical literature on telemedicine and i...
journal_title:Pediatric research
pub_type: 杂志文章,评审
doi:10.1038/pr.2015.192
更新日期:2016-01-01 00:00:00
abstract::The use of erythrocyte entrapment as a strategy to deliver and protect exogenously administered enzymes for replacement therapy in selected genetic diseases has been evaluated in a mammalian model system. The uptake, tissue distribution, intracellular localization, and in vivo lifetime of erythrocyte-entrapped bovine ...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-197512000-00011
更新日期:1975-12-01 00:00:00
abstract::EBV has been associated with several malignancies in humans. EBV can also infect marmoset B lymphocytes, which, as opposed to human B cells, are permissive for lytic Epstein-Barr viral replication. Mice with a severe combined immunodeficiency phenotype (SCID mice) are extremely susceptible to EBV-induced lymphomagenes...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-199410000-00007
更新日期:1994-10-01 00:00:00
abstract::Chenodeoxycholic acid labeled with 2H in the 11 and positions was prepared by catalytic reduction of delta 11-12 unsaturated derivatives of cholic acid. To validate the use of this stable isotope for the determination of bile acid kinetics by isotope dilution, it was administered to seven normal male volunteers simult...
journal_title:Pediatric research
pub_type: 杂志文章
doi:
更新日期:1975-10-01 00:00:00
abstract::Increased concentrations of carcinoembryonic antigen (CEA) have been reported in the sera and sputum of patients with cystic fibrosis. We have found significantly higher concentrations of CEA in both extracted and unextracted saliva of patients with cystic fibrosis compared to age-matched controls and a comparable gro...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-198003000-00002
更新日期:1980-03-01 00:00:00
abstract:BACKGROUND:Although it is commonly accepted that upper airway obstruction (UAO) increases gastroesophageal reflux (GER), the link is poorly understood and insufficiently documented. In addition, while hypoxia is often encountered in infants with UAO, its consequences on GER are virtually unknown. The two aims of the pr...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1038/s41390-020-0920-8
更新日期:2020-05-01 00:00:00
abstract::We injected 3-day-old (neonatal), 8-day-old (infant), and 8-wk-old (adult) Sprague-Dawley rats with monocrotaline to examine the effect of a toxic agent at various stages of lung development. Two and four weeks after injection the rats were killed and the heart and lungs removed: the right and left ventricles were sep...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-198507000-00019
更新日期:1985-07-01 00:00:00
abstract::Gaucher disease, the most common of the sphingolipidoses, results from the inherited deficiency of the enzyme glucocerebrosidase (EC 3.2.1.45). Although type 2 (acute neuronopathic) Gaucher disease is associated with rapidly progressive and fatal neurologic deterioration, the pathophysiologic mechanisms leading to the...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-200008000-00018
更新日期:2000-08-01 00:00:00
abstract::The renal effects of endothelin-1 were investigated in 16 anesthetized and mechanically ventilated newborn rabbits. Renal blood flow and glomerular filtration rate were determined by the clearance of para-aminohippuric acid and inulin, respectively. Each animal acted as its own control. In eight newborn rabbits, a bol...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-199308000-00002
更新日期:1993-08-01 00:00:00
abstract::The purpose of this study was to investigate atrial myocardial blood flow in the fetus under conditions of acute right ventricular pressure load and adenosine infusion. Late gestation fetal sheep were instrumented for acute right ventricular pressure loading or adenosine infusion, and regional myocardial blood flow wa...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-199403000-00010
更新日期:1994-03-01 00:00:00
abstract::Dexamethasone (Dex) and triiodothyronine (T3) were administered to pregnant rats during late gestation to evaluate potential developmental effects on fetal lung vitamin K-dependent carboxylation. Maternal rats were injected on the 2 d before study with Dex (0.2 mg/kg intraperitoneally), with T3 (0.7, 3.5, or 7 mg/kg i...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-198905000-00021
更新日期:1989-05-01 00:00:00
abstract::There is in vitro evidence that the ductus venosus of the fetal and newborn lamb relaxes to administration of E-series prostaglandins. We performed this study to determine whether the ductus venosus of the newborn lamb could be reopened by an infusion of prostaglandin E1. Fifteen lambs between 4 and 28 h of life and s...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-198703000-00002
更新日期:1987-03-01 00:00:00
abstract::In view of their known high incidence of noninsulin dependent diabetes (NIDDM), we sought to determine whether Native American (Plains Indian) children and adolescents show evidence of risk factors for both NIDDM and cardiovascular disease. Children and adolescents between the ages of 4 and 19 y were recruited, and fi...
journal_title:Pediatric research
pub_type: 临床试验,杂志文章
doi:10.1203/00006450-199607000-00014
更新日期:1996-07-01 00:00:00
abstract::The effect of diet, human milk or formula, on gastric function (lipase and pepsin activity, pH, and volume) and intragastric digestion of fat was assessed in 28 appropriate for gestational age preterm infants (gestational age, 28.9 +/- 1.4, 29.1 +/- 0.9, 29.5 +/- 0.6 wk; birth weight, 1.00 +/- 0.14 to 1.18 +/- 0.07 kg...
journal_title:Pediatric research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1203/00006450-199609000-00011
更新日期:1996-09-01 00:00:00
abstract:BACKGROUND:Postnatal glucocorticoid therapy in the treatment of chronic lung disease benefits lung function, however it adversely affects brain development. We hypothesized that combined postnatal glucocorticoid and statin therapy diminishes adverse effects of glucocorticoids on the developing brain. METHODS:On postna...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1038/pr.2013.152
更新日期:2013-12-01 00:00:00
abstract::Surfactant-associated proteins (SP-A, SP-B, and SP-C) are critical for the endogenous function of surfactant. Keratinocyte growth factor (KGF) and vascular endothelial growth factor (VEGF) are key regulators of lung development. The objective of this study was to evaluate the effects of early mechanical ventilation on...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/PDR.0b013e3181256aeb
更新日期:2007-09-01 00:00:00
abstract::The ciliated, mucus-secreting urn cell complex (UCC) is found swimming in the coelomic cavity of the marine invertebrate Sipunculus nudus. This cell complex, which can be maintained in suspension cultures, responds to various stimuli by hypersecreting mucus in the form of a cohesive mucus "tail." This tail can be meas...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-198011000-00022
更新日期:1980-11-01 00:00:00
abstract::Hypoxic ischemia is a common cause of damage to the fetal and neonatal brain. Although systemic and cerebrovascular physiologic factors play an important role in the initial phases of hypoxic-ischemic injuries, the intrinsic vulnerability of specific cell types and systems in the developing brain may be more important...
journal_title:Pediatric research
pub_type: 杂志文章,评审
doi:10.1203/00006450-200106000-00003
更新日期:2001-06-01 00:00:00