Abstract：
OBJECTIVE:This study aims to observe the influence of 1,25-(OH)2D3 on airway inflammation and chemokine expression in asthmatic rats and to explore its significance in the treatment of asthma. MATERIALS AND METHODS:Wistar rats were randomly divided into a normal control group (N), an asthma group (A), a 1,25-(OH)2D3 group (VD), a budesonide group (P) and a 1,25-(OH)2D3 + budesonide treatment group (L). The acute asthma models were established through ovalbumin sensitisation and challenge. Lung tissues were stained with haematoxylin and eosin to observe pathologic changes, whereas an enzyme-linked immunosorbent assay was used to examine serum IgE, as well as the eosinophil chemoattractant protein (eotaxin) and interleukin-8 (IL-8) expression levels in bronchoalveolar lavage fluid and the serum. RESULTS:VD treatment partially reversed the characteristic pathological changes of airway inflammation. The IgE, eotaxin, and IL-8 expression levels in the VD group were significantly lower than those in the A group (p < 0.05) but remained higher than those in the control group (p < 0.05). CONCLUSIONS:1,25-(OH)2D3 reduces airway inflammation, airway hyperresponsiveness and airway remodeling by partially inhibiting chemokine production during airway inflammation, and 1,25-(OH)2D3 synergises with hormone therapy.
journal_name
Eur Rev Med Pharmacol Scijournal_title
European review for medical and pharmacological sciencesauthors
Tian WM,Yang YG,Shang YX,Cai XX,Chen WW,Zhang Hsubject
Has Abstractpub_date
2014-01-01 00:00:00pages
1762-9issue
12eissn
1128-3602issn
2284-0729journal_volume
18pub_type
杂志文章abstract：OBJECTIVE:The aim of this study was to investigate the expression of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) in juvenile rats with nephrotic syndrome, and to explore its effects on inflammatory changes and renal injury. MATERIALS AND METHODS:24 Sprague-Dawley (SD) rats were randomly divi...
journal_title：European review for medical and pharmacological sciences
pub_type： 杂志文章
doi：10.26355/eurrev_201905_17831
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abstract：OBJECTIVE:Alcoholic hepatitis (AH) is a type of alcoholic liver disorder caused by overconsumption of alcohol. The involvement of several transcription factors (TF), as the main regulators of disease related gene expression has been documented previously. However, despite the importance of analysis of gene regulatory n...
journal_title：European review for medical and pharmacological sciences
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doi：
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abstract：:Prurigo nodularis of Hyde is a skin disorder characterized by pruritic excoriated nodules. Improvement in pruritus and decrease in nodules was demonstrated in patients treated with oral thalidomide 200-400 mg daily. We report a case of a 52 year old woman with a history of widespread, persistent, and intensely pruriti...
journal_title：European review for medical and pharmacological sciences
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更新日期：2009-03-01 00:00:00
abstract：OBJECTIVE:Many pharmacological activities have been reported for Feijoa sellowiana. The aim of present study was to investigate antidepressant activities of its leaf and fruit extracts. MATERIALS AND METHODS:Antidepressant activities of methanolic extracts were evaluated by modified forced swimming test (FST) and tail...
journal_title：European review for medical and pharmacological sciences
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更新日期：2015-07-01 00:00:00
abstract：OBJECTIVE:Fatty liver may induce various complications including chronic hepatitis or liver cirrhosis, and is frequently occurred in obesity individuals. Advanced glycosylation end products (AGEs) were known to play a critical role in multiple liver diseases. This study, therefore, aimed to study the effect of AGEs on ...
journal_title：European review for medical and pharmacological sciences
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abstract：OBJECTIVE:To investigate the correlations of inflammatory factors, interleukin-6 (IL-6), IL-10, IL-13 and tumor necrosis factor-α (TNF-α), and composition of bacterial flora in the peritoneal fluid with infertility in endometriosis patients. PATIENTS AND METHODS:A total of 55 patients diagnosed with endometriosis and ...
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journal_title：European review for medical and pharmacological sciences
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更新日期：2014-01-01 00:00:00
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journal_title：European review for medical and pharmacological sciences
pub_type： 杂志文章,撤回出版物
doi：10.26355/eurrev_202009_22775
更新日期：2020-09-01 00:00:00
abstract：INTRODUCTION:The hysto-morfological composition of the ascending aorta wall gives to the vessel its characteristic elasticity/distensibility, which is deteriorated due to both physiological (age) and pathological events (hypertension, diabetes, dyslipidemia). This contributes to reduce the wall elasticity and to occurr...
journal_title：European review for medical and pharmacological sciences
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journal_title：European review for medical and pharmacological sciences
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更新日期：2016-04-01 00:00:00
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journal_title：European review for medical and pharmacological sciences
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