Codon recognition fidelity of ribosomes at the first and second positions does not decrease during aging.

abstract：:The oral health of older people is changing with reducing numbers of people relying on complete dentures for function, and retaining some natural teeth. Despite this there are substantial numbers of older people whose ability to chew foods is compromised by their oral health status, either because they have few or no ...

journal_title：Mechanisms of ageing and development

authors： Walls AW,Steele JG

更新日期：2004-12-01 00:00:00

abstract：:Functional defects that accumulate in the T cell compartment are thought to be responsible for the pronounced immunodeficiency that develops during ageing, and reduced production of T cells by the thymus as it undergoes involution has been suggested to contribute to this phenomenon. Understanding the mechanisms respon...

journal_title：Mechanisms of ageing and development

authors： Montecino-Rodriguez E,Dorshkind K

更新日期：1997-02-01 00:00:00

abstract：:This study aimed to assess platelets as a possible model for screening the accumulation of mitochondrial DNA mutations, particularly during normal ageing. For this purpose we isolated platelets from young and old donors selected by lack of systemic and haematological diseases. We studied the accumulation of a particul...

journal_title：Mechanisms of ageing and development

authors： Biagini G,Pallotti F,Carraro S,Sgarbi G,Pich MM,Lenaz G,Anzivino F,Gualandi G,Xin D

更新日期：1998-04-01 00:00:00

abstract：:Morphological studies on spontaneous systemic amyloidosis were conducted on 222 senescence-accelerated mice (SAM) (P) and on 150 mice in the senescence-resistant series (R). Among the pathologic findings, amyloidosis showed the highest incidence in both SAM (79.7%) and R (32.7%). Although an extensive deposition of am...

journal_title：Mechanisms of ageing and development

authors： Takeshita S,Hosokawa M,Irino M,Higuchi K,Shimizu K,Yasuhira K,Takeda T

更新日期：1982-09-01 00:00:00

abstract：:The healing of normal incisional wounds and ischemic flap wounds was investigated in young (10 weeks) and old (102-104 weeks) rats, together with the effect of treatment with hyperbaric oxygen on day 0-3 of healing. After 10 days of healing all biomechanical strength parameters of normal wounds were decreased by 30-40...

journal_title：Mechanisms of ageing and development

authors： Quirinia A,Viidik A

更新日期：1996-10-25 00:00:00

abstract：:Changes in activity of some hepatic enzymes related to UDP-glucuronic acid conjugation (UDP-glucose dehydrogenase and UDP-glucuronyl transferase) and glutathione-related enzymes (glutathione reductase and glutathione peroxidase) were investigated in male and female Wistar rats as a function of age. UDP-glucose dehydro...

journal_title：Mechanisms of ageing and development

authors： Santa Maria C,Machado A

更新日期：1988-08-01 00:00:00

abstract：:We have examined newly synthesized proteins in the young adult and in older populations of the nematode Caenorhabditis elegans using two-dimensional polyacrylamide gel electrophoresis (2D PAGE). A temperature-sensitive mutant strain, DH26, with a mean life span of about 15 days, under our conditions, was used to block...

journal_title：Mechanisms of ageing and development

authors： Johnson TE,McCaffrey G

更新日期：1985-05-31 00:00:00

abstract：:Twenty-six institutionalized elderly subjects, selected as healthy according to the SENIEUR protocol, were compared to adult controls to establish correlations between affective disorders and immune abnormalities and to investigate underlying neuroendocrine mechanisms. After an extensive psychodiagnostic examination, ...

journal_title：Mechanisms of ageing and development

authors： Bartoloni C,Guidi L,Frasca D,Antico L,Pili R,Cursi F,Di Giovanni A,Rumi C,Menini E,Carbonin P

更新日期：1991-09-01 00:00:00

abstract：:Relationships between nutrition and longevity are of growing interest. Here we analysed the influences of dietary restriction on the survival of Drosophila exposed to atmospheric oxygen or to chronic hypoxia. Dietary restriction was achieved by food dilution, by sucrose restriction or by yeast restriction. Sucrose and...

journal_title：Mechanisms of ageing and development

authors： Vigne P,Frelin C

更新日期：2007-05-01 00:00:00

abstract：:The effect of aging on patterns of food intake and nutrient selection was investigated using a longitudinal study. Male (n = 10) and female (n = 10) Wistar-Lou rats from 4 to 28 months of age were repeatedly submitted to a macronutrient self-selection (S-S) regimen while controls were maintained under a standard chow ...

journal_title：Mechanisms of ageing and development

authors： Veyrat-Durebex C,Boghossian S,Alliot J

更新日期：1998-07-15 00:00:00

abstract：:Hepatic growth and protein synthesis in vivo was studied with age in ad libitum-fed and dietary restricted rats in which the mean and maximum lifespan was significantly extended. Livers from underfed rats showed significantly lower DNA, RNA and protein contents, and total protein synthesis. The fractional rate of synt...

journal_title：Mechanisms of ageing and development

authors： Merry BJ,Holehan AM,Lewis SE,Goldspink DF

更新日期：1987-07-01 00:00:00

abstract：:During experiments on the molecular basis of morphological and functional changes observed in rat liver mitochondria upon aging, we found that the buoyant density profile of mitochondrial DNA (mtDNA) shows a wide distribution pattern especially in the lighter region than that of young rat liver mtDNA. The heterogeneou...

journal_title：Mechanisms of ageing and development

authors： Asano K,Amagase S,Matsuura ET,Yamagishi H

更新日期：1991-11-01 00:00:00

abstract：:It has been previously well documented that partial pressure of oxygen (PO2) and weight-specific rate of O2 consumption in chick embryo (Gallus gallus domesticus) transiently increase midway through the 21-day in ovo incubation period. The present study found that these oxidative changes were paralleled by the concent...

journal_title：Mechanisms of ageing and development

authors： Wilson JX,Lui EM,Del Maestro RF

更新日期：1992-08-01 00:00:00

abstract：:Semantic distinctions between "normal" aging, "pathological" aging (or age-related disease) and "premature" aging (otherwise known as segmental progeria) potentially confound important insights into the nature of each of the complex processes. Here we review a recent, unexpected discovery: the presence of longevity-as...

journal_title：Mechanisms of ageing and development

authors： van de Ven M,Andressoo JO,Holcomb VB,Hasty P,Suh Y,van Steeg H,Garinis GA,Hoeijmakers JH,Mitchell JR

更新日期：2007-01-01 00:00:00

abstract：:We studied the pattern of lectins binding by liver lysosomal proteins from rats between 18 days of gestation and 72 weeks of age. An analysis of the carbohydrate structure was carried out after an electrophoresis and blotting, followed by a very sensitive detection system with highly specific digoxigenin-labelled lect...

journal_title：Mechanisms of ageing and development

authors： Lityńska A,Przybyło M

更新日期：1998-05-01 00:00:00

abstract：:The aim of the present study was to measure protein synthesis in regenerating liver and to evaluate the impact of malnutrition in young and old rats. Two groups of male Wistar rats were used: young rats (4 months old) and old rats (18 months old). The rats were allocated to malnutrition or ordinary food intake for 1 w...

journal_title：Mechanisms of ageing and development

authors： Carrillo MC,Carnovale CE,Favre C,Monti JA,Scapini C

更新日期：1996-10-04 00:00:00

abstract：:Food restriction (FR) may increase longevity by increasing the efficiency of energy utilization by some organs. We tested whether any effect of FR on the energy efficiency of isolated, isovolumically beating hearts could be observed, by studying four groups of rats: (1). AL fed (AL) 10-13-month-old rats, (2). age matc...

journal_title：Mechanisms of ageing and development

authors： Klebanov S,Herlihy JT,Freeman GL

更新日期：2002-07-01 00:00:00

abstract：:Components of the calmodulin system (i.e., calmodulin levels and activities of the following calmodulin-dependent enzymes: Ca2+ + Mg2+-ATPase, adenylate and guanylate cyclases, cyclic AMP and cyclic GMP phosphodiesterases, and Ca2+-dependent protein kinase were studied in the following brain regions from immature (25-...

journal_title：Mechanisms of ageing and development

authors： Hoskins B,Ho IK

更新日期：1986-10-01 00:00:00

abstract：:Oxidative stress may contribute to the cellular alterations, which occur as the result of aging, and the nervous system is particularly vulnerable to aging associated oxidative injury. The multicatalytic proteasome (MCP) is responsible for the majority of protein degradation and is sensitive to oxidative stress. To de...

journal_title：Mechanisms of ageing and development

authors： Keller JN,Hanni KB,Markesbery WR

更新日期：2000-01-24 00:00:00

abstract：:Chronic oxidative stress is generally believed to be a major etiologic factor in the aging process. In addition to modulation of signaling processes and oxidation of cellular proteins and lipids, reactive oxygen species (ROS) induce multiple damages in both nuclear and mitochondrial genomes, most of which are repaired...

journal_title：Mechanisms of ageing and development

authors： Szczesny B,Bhakat KK,Mitra S,Boldogh I

更新日期：2004-10-01 00:00:00

abstract：:Epigenetic modifications, including changes in DNA methylation, have been implicated in a wide range of diseases including neurological diseases such as Alzheimer's. The role of dietary folate in providing methyl groups required for maintenance and modulation of DNA methylation makes it a nutrient of interest in Alzhe...

journal_title：Mechanisms of ageing and development

authors： Robinson N,Grabowski P,Rehman I

更新日期：2018-09-01 00:00:00

abstract：:Circulating antibodies in the sera of normal, healthy humans of different age groups to native DNA (nDNA) and reactive oxygen species modified DNA (ROS-DNA) was studied by competition ELISA. Sera from the young population (< 50 years of age) showed negligible levels of anti-DNA antibodies. In contrast, anti-DNA antibo...

journal_title：Mechanisms of ageing and development

authors： Ashok BT,Ali R

更新日期：1998-06-01 00:00:00

abstract：:The mTOR deregulation has a role in chronic kidney disease including diabetic nephropathy. SIRT1 is an important participant in renal cytoprotective responses to aging and stress. However, whether both mTOR and SIRT1 are involved in high glucose-inducing mesangial cells (MCs) senescence still remains to be explored. H...

journal_title：Mechanisms of ageing and development

authors： Zhang S,Cai G,Fu B,Feng Z,Ding R,Bai X,Liu W,Zhuo L,Sun L,Liu F,Chen X

更新日期：2012-06-01 00:00:00

abstract：:The effects of long-term caloric restriction on the hepatic phase II drug metabolizing enzymes were investigated in the male Fischer 344 rat. Rats that had been restricted to 60% of their pair-fed control consumption from 14 weeks post-partum exhibited altered conjugating enzyme activities at 22 months. Caloric restri...

journal_title：Mechanisms of ageing and development

authors： Leakey JA,Cunny HC,Bazare J Jr,Webb PJ,Lipscomb JC,Slikker W Jr,Feuers RJ,Duffy PH,Hart RW

更新日期：1989-05-01 00:00:00

abstract：:The microtubule-associated protein tau, and the cytoplasmic protein ubiquitin, are constituents of pathological neurofibrillary tangles found in Alzheimer's disease. In order to see if there is any physiological relationship between these proteins in a functioning human system, human neuroblastoma (LAN-5) cells were g...

journal_title：Mechanisms of ageing and development

authors： Mesco ER,Timiras PS

更新日期：1991-11-15 00:00:00

abstract：:Ageing is the most complex phenotype currently known, since it becomes manifest in all organs and tissues, affects an organism's entire physiology, impacts function at all levels and increases susceptibility to all major chronic diseases. Insight into the molecular and cellular targets of the ageing process would offe...

journal_title：Mechanisms of ageing and development

authors： Vijg J,Suh Y

更新日期：2003-01-01 00:00:00

abstract：:It is generally accepted that free-radical induced blood lipid peroxidation and especially peroxidized LDL play a central role in the pathogenesis of atherosclerosis and related cardiovascular disease. Moreover, recent research highlights the key contribution of apolipoprotein B (apo B) to atherogenesis as the main in...

journal_title：Mechanisms of ageing and development

authors： Ramírez-Boscá A,Soler A,Carrión MA,Díaz-Alperi J,Bernd A,Quintanilla C,Quintanilla Almagro E,Miquel J

更新日期：2000-10-20 00:00:00

abstract：:Taurine is a sulfur amino acid that is present in high concentration in mammalian tissues and previously has been reported to decline in a number of tissues with advancing age. The aims of the present study were to examine: (1) the effects of dietary taurine supplementation; (2) the effects of taurine-free diets; (3) ...

journal_title：Mechanisms of ageing and development

authors： Dawson R Jr,Liu S,Eppler B,Patterson T

更新日期：1999-02-01 00:00:00

abstract：:Many molecular chaperones are also known as heat shock proteins because they are synthesised in increased amounts after brief exposure of cells to elevated temperatures. They have many cellular functions and are involved in the folding of nascent proteins, the re-folding of denatured proteins, the prevention of protei...

journal_title：Mechanisms of ageing and development

authors： Proctor CJ,Soti C,Boys RJ,Gillespie CS,Shanley DP,Wilkinson DJ,Kirkwood TB

更新日期：2005-01-01 00:00:00

abstract：:In the present study, a number of physiological and behavioral measures that are related to metabolism were continuously monitored in 19-month-old male Fischer 344 rats that were fed ad libitum or fed a caloric restricted diet. Caloric restricted rats ate fewer meals but consumed more food during each meal and spent m...

journal_title：Mechanisms of ageing and development

authors： Duffy PH,Feuers RJ,Leakey JA,Nakamura K,Turturro A,Hart RW

更新日期：1989-05-01 00:00:00