A parametric evaluation of the hedonic and motoric effects of drugs: pimozide and amphetamine.

Abstract:

:This study uses a curve-fitting approach to evaluate the effects of drugs on reinforced responding in rats. The subjects obtained reinforcement according to a series of five different variable-interval schedules (a five-component multiple schedule). For each rat, pimozide, a neuroleptic, decreased response rate, and the decrease was associated with (1) a decrease in the estimated asymptotic response rate and (2) an increase in the rate of reinforcement necessary for half-asymptotic responding. That is, pimozide decreased the proportion of responding maintained by a given rate of reinforcement. In contrast, intermediate doses of amphetamine increased response rate and increased the proportion of responding maintained by a given rate of reinforcement. It was proposed that the response rate asymptote indexes motor capacity, and the rate of reinforcement necessary for half-asymptotic responding indexes reinforcement efficacy; accordingly, pimozide decreased motor capacity and reinforcement strength and amphetamine increased reinforcement strength.

journal_name

J Exp Anal Behav

authors

Heyman GM

doi

10.1901/jeab.1983.40-113

subject

Has Abstract

pub_date

1983-09-01 00:00:00

pages

113-22

issue

2

eissn

0022-5002

issn

1938-3711

journal_volume

40

pub_type

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