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Carrier detection in X-linked Becker muscular dystrophy by muscle provocation test (MPT).

Abstract：

:The muscle provocation test (MPT: 40 min of strenuous exercise on a bicycle ergometer) is a sensitive method for the detection of carriers of Duchenne muscular dystrophy. The diagnostic applicability of MPT for carrier detection in X-linked Becker muscular dystrophy is demonstrated. Obligate carriers with mean creatine kinase (CK) values on repeated determination within the normal range showed a greater CK elevation after MGP than control subjects. Three of seven daughters of obligate carriers with normal resting CK activity had increased CK activity after MPT. These data suggest that the use of MPT may enhance the capability to discriminate carriers for these X-linked recessive genes.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Herrmann FH,Spiegler AW

doi

10.1016/0022-510x(83)90194-6

subject

Has Abstract

pub_date

1983-12-01 00:00:00

pages

141-6

issue

1-3

eissn

0022-510X

issn

1878-5883

pii

0022-510X(83)90194-6

journal_volume

62

pub_type

杂志文章

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