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In vitro cellular responsiveness in multiple sclerosis patients to a purified measles virus nuclear core and to other viral antigens.

Abstract：

:The Clausen modification of the peripheral blood buffy coat leukocyte migration test was used to test patients with multiple sclerosis, normal subjects and patients with other neurologic diseases for cell-mediated immunity to commercial measles virus, purified nuclear core material from a human neurotropic strain of measles virus, as well as to commercial preparations of rubella, mumps and parainfluenza HA2. Leukocytes of multiple sclerosis patients showed significantly less mean inhibition of migration in the presence of both measles antigens, mumps and parainfluenza but no difference from controls when incubated with rubella. No correlation could be found between the degree of migration inhibition and concomitant serum anti-measles neutralization antibody titers to the same strain of virus. The use of purified viral antigens might result in more meaningful studies of the status of cellmediated immunity to viral antigens in multiple sclerosis. The relationship of our findings to other studies in this area and to the pathogenesis of multiple sclerosis is discussed.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Ciongoli AK,Lisak RP,Zweiman B,Koprowski H,Waters D

doi

10.1016/0022-510x(76)90026-5

subject

Has Abstract

pub_date

1976-07-01 00:00:00

pages

331-8

issue

3

eissn

0022-510X

issn

1878-5883

pii

0022-510X(76)90026-5

journal_volume

28

pub_type

杂志文章

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