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Oligonucleotide-templated reactions based on Peptide Nucleic Acid (PNA) probes: concept and biomedical applications.

Abstract：

:Sensing technologies based on Peptide Nucleic Acids (PNAs) and oligonucleotide-templated chemistry are perfectly suited for biomedical applications (e.g., diagnosis, prognosis and stratification of diseases) and could compete well with more traditional amplification technologies using expensive dual-labelled oligonucleotide probes. PNAs can be easily synthesised and functionalised, are more stable and are more responsive to point-mutations than their DNA counterpart. For these reasons, fluorogenic PNAs represent an interesting alternative to DNA-based molecular beacons for sensing applications in a cell-free environment, where cellular uptake is not required.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Choi Y,Metcalf G,Sleiman MH,Vair-Turnbull D,Ladame S

doi

10.1016/j.bmc.2014.05.071

subject

Has Abstract

pub_date

2014-08-15 00:00:00

pages

4395-8

issue

16

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(14)00430-1

journal_volume

22

pub_type

杂志文章

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