Abstract:
:A suspension of micronized prednisolone acetate was separated into four fractions by the technique of centrifugal elutriation. Data showed that each fraction had a narrow particle size. The dissolution experiments were carried out under sink conditions (less than 10% of saturation concentration) in a dissolution apparatus with a rotating filter assembly and a continuous circulation of filtered fluid samples through a recording spectrophotometer. The dissolution profile was highly reproducible and substantially different for each fraction. As expected, fractions with the smallest and largest particles showed the fastest and slowest dissolution, respectively. Almost the entire dissolution profiles for four small particle size fractions can be satisfactorily described by the Higuchi-Hiestand model with the dissolution rate constant, K, in the range of 1.5-2.0 X 10(-9)cm2/sec. This is approximately 3.5 times greater than the value for K calculated on the basis of reported reasonable values for diffusion coefficient, density, and solubility.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Mauger JW,Howard SA,Amin Kdoi
10.1002/jps.2600720225subject
Has Abstractpub_date
1983-02-01 00:00:00pages
190-3issue
2eissn
0022-3549issn
1520-6017pii
S0022-3549(15)44489-2journal_volume
72pub_type
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