Abstract:
:The disposition kinetics of nicotine and cotinine enantiomers was determined in rabbits. The clearance of (R)-nicotine was similar to that of (S)-nicotine, but clearance of (R)-cotinine was twice that of (S)-cotinine. Fractional conversions of both enantiomers of nicotine to cotinine were approximately 50%. These results suggest that in rabbits the biotransformation pathways of cotinine, but not nicotine, are influenced by stereochemistry. The disposition kinetics of nicotine enantiomers in beagle dogs was also studied. In dogs, the clearance of (R)-nicotine was slightly greater than the clearance of (S)-nicotine. Methods for the synthesis of (R)-nicotine and (R)-cotinine of high enantiomeric purity and a gas chromatographic method for determination of nicotine enantiomeric purity are described.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Jacob P 3rd,Benowitz NL,Copeland JR,Risner ME,Cone EJdoi
10.1002/jps.2600770508subject
Has Abstractpub_date
1988-05-01 00:00:00pages
396-400issue
5eissn
0022-3549issn
1520-6017pii
S0022-3549(15)47683-Xjournal_volume
77pub_type
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