Abstract:
:An HPLC method for the simultaneous determination of safrole (S), dihydrosafrole (DHS), and chloromethyldihydrosafrole (CM-DHS) in piperonyl butoxide, with fluorimetric detection and elution gradient, is described. Samples with internal standard (piperonyl isobutyrate) are adsorbed on silica cartridges, then eluted with an appropriate solvent. Internal standard, S, DHS, and CMDHS are eluted together and injected into a reversed-phase chromatography column. The concentrations of the three products are calculated from calibration graphs, and linearity and reproducibility are verified. The limit of detection is 2 mg.kg-1. This analytical method allows for control of the synthesis process of piperonyl butoxide and determination of some carcinogenic substances, such as S and DHS.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Schreiber-Deturmeny EM,Pauli AM,Pastor JLdoi
10.1002/jps.2600820812subject
Has Abstractpub_date
1993-08-01 00:00:00pages
813-6issue
8eissn
0022-3549issn
1520-6017pii
S0022-3549(15)49209-3journal_volume
82pub_type
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