Determination of safrole, dihydrosafrole, and chloromethyldihydrosafrole in piperonyl butoxide by high-performance liquid chromatography.

Abstract:

:An HPLC method for the simultaneous determination of safrole (S), dihydrosafrole (DHS), and chloromethyldihydrosafrole (CM-DHS) in piperonyl butoxide, with fluorimetric detection and elution gradient, is described. Samples with internal standard (piperonyl isobutyrate) are adsorbed on silica cartridges, then eluted with an appropriate solvent. Internal standard, S, DHS, and CMDHS are eluted together and injected into a reversed-phase chromatography column. The concentrations of the three products are calculated from calibration graphs, and linearity and reproducibility are verified. The limit of detection is 2 mg.kg-1. This analytical method allows for control of the synthesis process of piperonyl butoxide and determination of some carcinogenic substances, such as S and DHS.

journal_name

J Pharm Sci

authors

Schreiber-Deturmeny EM,Pauli AM,Pastor JL

doi

10.1002/jps.2600820812

subject

Has Abstract

pub_date

1993-08-01 00:00:00

pages

813-6

issue

8

eissn

0022-3549

issn

1520-6017

pii

S0022-3549(15)49209-3

journal_volume

82

pub_type

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