Abstract:
:The phthalate acid esters (PAEs), and, in particular, di(2-ethylhexyl) phthalate (DEHP) and its monoester, monoethylhexyl phthalate (MEHP), can adversely affect rodent testes but only at high doses. Rat gonadal zinc levels can be decreased by the injection of DEHP, but not MEHP. The rat prostate gland seems to be particularly sensitive to PAE-induced zinc depletion. PAE-induced changes in male reproductive organs were more evident in the rat than in the mouse. Some of the effects of MEHP can be demonstrated in vitro since it can alter the uptake of 65Zn in rodent gonads and accessory sex organs.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Thomas JA,Curto KA,Thomas MJdoi
10.1289/ehp.824585subject
Has Abstractpub_date
1982-11-01 00:00:00pages
85-8eissn
0091-6765issn
1552-9924journal_volume
45pub_type
杂志文章abstract::It has been estimated that 4 of 1,000 live births and 35% of spontaneous abortions are aneuploid and that an important proportion of embryo and newborn aneuploidy is of paternal origin. Exposure to organophosphorous pesticides (OP) has been associated with sperm hyperploidy/polyploidy. Therefore, we aimed to assess th...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.011091237
更新日期:2001-12-01 00:00:00
abstract::During 1992 and 1993 the Wisconsin Division of Health investigated five cases in which copper-contaminated drinking water was suspected of causing gastrointestinal upsets. Each of these case studies was conducted after our office was notified of high copper levels in drinking water or notified of unexplained illnesses...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.94102958
更新日期:1994-11-01 00:00:00
abstract:BACKGROUND:Exposure to certain phenols is ubiquitous because of their use in many consumer and personal care products. However, predictors of exposure have not been well characterized in most populations. OBJECTIVES:We sought to identify predictors of exposure and to assess the reproducibility of phenol concentrations...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1306830
更新日期:2014-07-01 00:00:00
abstract::Whole blood oxygen equilibrium curves (O2 ECs), blood buffer lines, and several hematologic properties were determined for adult guinea pigs exposed to 700 ppm methyl isocyanate (MIC) for 15 min. MIC inhalation effected a significant reduction of blood O2 affinity; the half-saturation pressure (P50) at 38 degrees C in...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.877235
更新日期:1987-06-01 00:00:00
abstract::In 1996 the U.S. Congress charged the U.S. Environmental Protection Agency to develop a screening program to test chemicals for their possible estrogenic and other endocrine effects. Shortly thereafter, the Chemical Guidelines Program of the Organisation for Economic Co-operation and Development's (OECD) Environmental...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.02110s3363
更新日期:2002-06-01 00:00:00
abstract:BACKGROUND:Industrial air pollution is a public health hazard. Previous evidence documented increased respiratory symptoms and hospitalizations in children who live near the factories in the largest chipboard manufacturing district in Italy (Viadana). OBJECTIVES:We evaluated the association of outdoor exposure to form...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1307259
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND:The association of DDT (dichlorodiphenyltrichloroethane) with breast cancer is controversial, but animal studies directly linking DDT to risk are lacking. Concerns with DDT reside in its environmental persistence, bioaccumulation in breast adipose tissue, and endocrine-disrupting actions. Whereas most attent...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1104327
更新日期:2012-08-01 00:00:00
abstract::Cap43 is a protein whose RNA is induced under conditions of severe hypoxia or prolonged elevations of intracellular calcium. Additionally, Ni and Co also induce Cap43 because they produce a state of hypoxia in cells. Cap43 protein is expressed at low levels in normal tissues; however, in a variety of cancers, includin...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.02110s5783
更新日期:2002-10-01 00:00:00
abstract:BACKGROUND:Per- and polyfluoroalkyl substances (PFAS) are widespread persistent organic pollutants and endocrine disruptors. High doses of perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) exposure can cause pregnancy loss and infant deaths in animals, but the associations between PFAS exposures and...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP6202
更新日期:2020-04-01 00:00:00
abstract::During a 2-year chronic inhalation study on methylene chloride (2000 or 0 ppm; 6 hr/day, 5 days/week), gas-uptake pharmacokinetic studies and tissue partition coefficient determinations were conducted on female B6C3F1, mice after 1 day, 1 month, 1 year, and 2 years of exposure. Using physiologically based pharmacokine...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.96104858
更新日期:1996-08-01 00:00:00
abstract::We previously reported that cell cultures of human proximal tubule (HPT) cells respond to ionic cadmium in a manner consistent with well-defined Cd(2+)-elicited responses reported for in vivo systems. However, one unique finding was that the transepithelial electrical resistance and tight junction sealing strands were...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.93101510
更新日期:1993-11-01 00:00:00
abstract::Mineral fibers and particulates represent one of the best documented, economically important, and ubiquitously occurring categories of human carcinogens. Yet, while a wealth of information exists concerning the mechanism of action of physical, chemical, and viral carcinogens, virtually nothing is known relative to the...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.803459
更新日期:1980-02-01 00:00:00
abstract::The 11 September 2001 terrorist attack on New York City's World Trade Center (WTC) caused an unprecedented environmental emergency. The collapse of the towers sent a tremendous cloud of crushed building materials and other pollutants into the air of lower Manhattan. In response to the calamity, federal, state, and cit...
journal_title:Environmental health perspectives
pub_type: 评论,杂志文章
doi:10.1289/ehp.111-1241533
更新日期:2003-06-01 00:00:00
abstract::Dysmenorrhea is a common gynecologic disorder in women of reproductive age. Previous studies have found an association between current cigarette smoking and prevalence of dysmenorrhea. This study investigated the association between exposure to environmental tobacco smoke (ETS) and the occurrence of dysmenorrhea among...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.001081019
更新日期:2000-11-01 00:00:00
abstract::Exposure to aflatoxin B1 (AFB1), an important cofactor in the etiology of hepatocellular carcinoma in Taiwan, is influenced by dietary and other factors. The present study examined the intraindividual variability in AFB1-albumin adducts, the most reliable long-term biomarker of AFB1 exposure, and whether the baseline ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.01109833
更新日期:2001-08-01 00:00:00
abstract::Human health and aquatic animal health are organically related at three distinct interfaces. Aquatic animals serve as important contributors to the nutritional protein, lipid, and vitamin requirements of humans; as carriers and transmitters of many infectious and parasitic diseases to which humans are susceptible; and...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.9086245
更新日期:1990-06-01 00:00:00
abstract::Diffuse pulmonary fibrosis is associated with bleomycin administration to humans. The sequential reactions of lung cells to this drug have now been investigated in mice following injection of 20 mg/kg bleomycin twice per week for 4 to 8 weeks. Cytoplasmic and subendothelial edema was first observed in large vessels an...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7616119
更新日期:1976-08-01 00:00:00
abstract::Polybrominated biphenyls (PBBs) cause a mixed-type (phenobarbital- plus 3-methylcholanthrene-like) induction of liver microsomal drug metabolizing enzymes in rats. However, 2,2',4,4',5,5'-hexabromobiphenyl and 2,2',3,4,4',5,5'-heptabromobiphenyl, which together comprise less than 80% of PBBs (FireMaster), were shown t...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7823159
更新日期:1978-04-01 00:00:00
abstract::Southwest metropolitan Mexico City (SWMMC) inhabitants have been exposed several hours per day for the last 6 years to photochemical smog, ozone being the most important oxidant pollutant. Subjects exposed to the SWMMC atmosphere develop several histopathological changes in their nasal mucosa: dysplasia is the most si...
journal_title:Environmental health perspectives
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1289/ehp.101-1519752
更新日期:1993-06-01 00:00:00
abstract::Reaction of chromium(VI) with one equivalent of ascorbate was studied by electron paramagnetic resonance spectroscopy in the presence of 0.10 M 5,5-dimethyl-1-pyrroline-1-oxide (DMPO) at room temperature in 0.10 M (N-[2-hydroxyethyl]piperazine-N'-[2-ethanesulfonic acid]) (HEPES) and 0.05 M tris(hydroxymethyl)aminometh...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.94102s321
更新日期:1994-09-01 00:00:00
abstract:BACKGROUND:In a changing climate, increasing temperatures are anticipated to have profound health impacts. These impacts could be mitigated if individuals and communities adapt to changing exposures; however, little is known about the extent to which the population may be adapting. OBJECTIVE:We investigated the hypoth...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1307392
更新日期:2014-08-01 00:00:00
abstract::This paper examines recent risk assessments for benzene and observes a number of inconsistencies within the study and consistencies between studies that should effect the quantitative determination of the risk from benzene exposure. Comparisons across studies show that only acute myeloid leukemia (AML) is found to be ...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.8982289
更新日期:1989-07-01 00:00:00
abstract:BACKGROUND:Arsenic (As) occurs as monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA) in humans, and the methylation pattern demonstrates large interindividual differences. The fraction of urinary MMA is a marker for susceptibility to As-related diseases. OBJECTIVES:We evaluated the impact of polymorphisms in ...
journal_title:Environmental health perspectives
pub_type: 杂志文章,随机对照试验
doi:10.1289/ehp.1002471
更新日期:2011-02-01 00:00:00
abstract::Acetylcholinesterase (AChE) is the enzyme that hydrolyzes the neurotransmitter acetylcholine at cholinergic synapses and neuromuscular junctions. However, results from our laboratory and others indicate that AChE has an extrasynaptic, noncholinergic role during neural development. This article is a review of our findi...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.99107s181
更新日期:1999-02-01 00:00:00
abstract:BACKGROUND:Population-based studies have estimated health risks of short-term exposure to fine particles using mass of PM(2.5) (particulate matter journal_title:Environmental health perspectives pub_type: 杂志文章 doi:10.1289/ehp.0800185 更新日期:2009-06-01 00:00:00
abstract::The problems of quantitating chrysotile in water by fiber count techniques are reviewed briefly and the use of mass quantitation is suggested as a preferable measure. Chrysotile fiber has been found in almost every sample of natural water examined, but generally transmission electron miscroscopy (TEM) is required beca...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.749161
更新日期:1974-12-01 00:00:00
abstract::Numerous publications and reports have expressed health and safety concerns about the production and use of nanoparticles, especially in areas of exposure monitoring, personal use, and environmental fate and transport. We suggest that stable isotopic tracers, which have been used widely in the earth sciences and in me...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9277
更新日期:2006-10-01 00:00:00
abstract::The purpose of this investigation was to determine whether there has been a change in the human blood concentration of perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA), and five other fluorochemicals since 1974. Blood samples were collected in 1974 (serum) and 1989 (plasma) from volunteer participants of a l...
journal_title:Environmental health perspectives
pub_type: 历史文章,杂志文章
doi:10.1289/ehp.7544
更新日期:2005-05-01 00:00:00
abstract::Epidemiologic studies demonstrate that infection, specifically pneumonia, contributes substantially to the increased morbidity and mortality among elderly individuals following exposure to ambient particulate matter (PM). This laboratory has previously demonstrated that a single inhalation exposure of Streptococcus pn...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.02110s5871
更新日期:2002-10-01 00:00:00
abstract::The study reported here presents the results of an investigation of a marsh-cove ecosystem heavily contaminated by cadmium. The most contaminated aquatic sediments were dredged in 1972-73, but the resuspension of the sediments and recycle of water from the dredge spoil resulted in reestablishment of a large contaminat...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.792867
更新日期:1979-02-01 00:00:00