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Serum and urinary ribonuclease in children with schistosomal hepatic fibrosis.

Abstract：

:Serum and urinary RNase activity was determined in 15 normal children and in 52 children in various clinical stages of schistosomal hepatic fibrosis. The activity of serum RNase was compared with that of serum GOT, GPT and AP. The activity of serum and urinary RNase in the different schistosomal groups was significantly higher than in healthy children. The elevated levels of serum and urinary RNase activity were possibly due to malnutrition with tissue catabolism, zinc-deficiency and liver cell injury. Treatment with Astiban and protein-rich diet resulted in a significant decrease in serum and urinary RNase activity and an in significant drop in serum GOT, GPT and AP. Serum and urinary RNase appear to be more sensitive indices for evaluating the early metabolic disturbances in schistosomal patients than GOT, GPT or AP. Our findings also showed that the severity of cases could be graded according to the level of urinary RNase.

journal_name

Trans R Soc Trop Med Hyg

journal_title

Transactions of the Royal Society of Tropical Medicine and Hygiene

authors

Zeitoun MM,Hamam MA,Kantoosh M,Abdel-Moneim MA,el-Sewedy SM

doi

10.1016/0035-9203(78)90018-4

subject

Has Abstract

pub_date

1978-01-01 00:00:00

pages

631-6

issue

6

eissn

0035-9203

issn

1878-3503

journal_volume

72

pub_type

杂志文章

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