Magnitude and duration of the effects of cocaine on conditioned and adjunctive behaviors in the chimpanzee.

Abstract:

:Characteristic patterns of conditioned key-pressing were maintained in the chimpanzee under a multiple 30-response fixed-ratio, 10-minute fixed-interval schedule of food presentation. Adjunctive drinking occurred with regularity during the fixed-interval schedule and, with less frequency, during 1-minute timeout periods that followed each food presentation; drinking seldom occurred during the fixed-ratio schedule. Cocaine increased key pressing under the fixed-interval schedule at doses between .1 and 3.0 mg/kg, but adjunctive drinking and key pressing under the fixed-ratio schedule did not increase at any dose. Conditioned and adjunctive behaviors were disrupted and suppressed for different durations at 10,0 mg/kg, a dose which induced convulsive seizures within 10 minutes after intramuscular injection. A time-course analysis showed the magnitude and duration of the effects of cocaine on key pressing under the fixed-interval schedule and on adjunctive drinking to be dose-related. Moreover, a given dose of cocaine had diverse effects, depending on the behavior and the time since drug administration.

journal_name

J Exp Anal Behav

authors

Byrd LD

doi

10.1901/jeab.1980.33-131

subject

Has Abstract

pub_date

1980-01-01 00:00:00

pages

131-40

issue

1

eissn

0022-5002

issn

1938-3711

journal_volume

33

pub_type

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