Abstract:
:Behavior maintained by intravenously delivered alfentanil, cocaine, or ketamine was assessed using a fixed-ratio schedule of reinforcement. As the dose of each drug was increased, rate of responding also increased up to a maximum. Further increases in dose resulted in decreased response rates (inverted U-shaped curve). An analysis of postreinforcement-pause-time and run-time measures for the ascending limb of the inverted U-shaped functions revealed that behavior was characterized by systematic decreases in both pause time and run time as dose and rate increased. An examination of the descending limb of the dose-response functions revealed that lowered response rates for cocaine and ketamine were correlated with increases in run time and small and inconsistent effects on postreinforcement pause time. Behavior maintained by rate-reducing doses of alfentanil was characterized by lengthened postreinforcement pauses with small increases in run time. These data suggest that at larger doses, drug reinforcers may have unconditioned or direct effects on the behavior that the drug is maintaining, and more important, that the nature of these unconditioned effects depends on the drug that is maintaining behavior.
journal_name
J Exp Anal Behavjournal_title
Journal of the experimental analysis of behaviorauthors
Skjoldager P,Winger G,Woods JHdoi
10.1901/jeab.1991.56-331subject
Has Abstractpub_date
1991-09-01 00:00:00pages
331-43issue
2eissn
0022-5002issn
1938-3711journal_volume
56pub_type
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journal_title:Journal of the experimental analysis of behavior
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Journal of the experimental analysis of behavior
pub_type: 杂志文章
doi:10.1002/jeab.558
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pub_type: 杂志文章
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journal_title:Journal of the experimental analysis of behavior
pub_type: 杂志文章
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更新日期:1984-09-01 00:00:00
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journal_title:Journal of the experimental analysis of behavior
pub_type: 杂志文章
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更新日期:1973-03-01 00:00:00
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journal_title:Journal of the experimental analysis of behavior
pub_type: 杂志文章
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journal_title:Journal of the experimental analysis of behavior
pub_type: 杂志文章
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更新日期:1965-05-01 00:00:00
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journal_title:Journal of the experimental analysis of behavior
pub_type: 杂志文章
doi:10.1901/jeab.1977.27-127
更新日期:1977-01-01 00:00:00