Abstract:
:Thirty-one patients aged over 60 yrs and with lupus anticoagulant (LA) were reviewed for their drug intake. Twenty-three (73%) were taking cinchona alkaloids, 10 (32%) quinine for night cramps, 11 (35%) quinidine for cardiac arrhythmia and 2 (6%) were taking both. These frequencies of drugs usage differed significantly from age and sex matched controls (p < 0.001). Five patients had features suggestive of the antiphospholipid syndrome. Repeat testing showed persistent LA activity in all but 2 of 5 patients in whom the relevant drug had been ceased. This is the first description of a possible causal association between LA and quinine therapy.
journal_name
Pathologyjournal_title
Pathologyauthors
Bird MR,O'Neill AI,Buchanan RR,Ibrahim KM,Des Parkin Jdoi
10.1080/00313029500169742subject
Has Abstractpub_date
1995-04-01 00:00:00pages
136-9issue
2eissn
0031-3025issn
1465-3931journal_volume
27pub_type
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