Abstract：
:Carcinogens occur naturally in the foods we eat, including a number of HCAs that have been identified in foods (beef, pork, poultry and fish) as a result of cooking. These compounds are formed during the normal cooking process by the reaction of creatine with various amino acids. The HCAs have been identified as a result of their high mutagenic activity in the Ames test. The HCAs can be separated into two types, the nonimidazole and the imidazole type, the latter of which is the predominant type present in Western foods. Both types of HCAs have been found to be carcinogenic in rodent bioassays. Of the three imidazole compounds presently under evaluation in nonhuman primates, IQ has been found to be a potent carcinogen, inducing hepatocellular carcinoma in a majority of the animals in approximately one-seventh of their life span. In addition, a high proportion of the nonhuman primates also had focal IQ-induced myocardial lesions as observed by both light and electron microscopic findings. This information, along with other toxicology data on the HCAs, much of which is cited in this paper, allows the inference to be made that HCAs may be a risk factor for both cancer and cardiovascular disease in humans.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Adamson RH,Thorgeirsson UPdoi
10.1007/978-1-4615-1957-7_20subject
Has Abstractpub_date
1995-01-01 00:00:00pages
211-20eissn
0065-2598issn
2214-8019journal_volume
369pub_type
杂志文章,评审abstract：:Although controversial, animal and tissue studies indicate that carotid bodies are sensitive to changes in glucose as well as in oxygen, thereby functioning as metabolic sensors. This study was designed to test the hypothesis that carotid bodies in humans participate in the counter-regulatory response to insulin-induc...
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pub_type： 杂志文章
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journal_title：Advances in experimental medicine and biology
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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更新日期：1999-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：1999-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：1989-01-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2017-01-01 00:00:00
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更新日期：2014-01-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2018-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4615-9026-2_23
更新日期：1975-01-01 00:00:00
