Abstract：
:Signaling in tenocytes during development, homeostasis and injury involves multiple and redundant pathways. Given that tendons transmit mechanical forces from muscle to bone to effect movement, a key function for tenocytes is the detection of and response to mechanical stimulation. Mechanotransduction involves matrix-integrin-cytoskeleton to nucleus signaling, gap junction intercellular communication, changes in intracellular calcium (Ca(2+)), activation of receptors and their pathways, and responses to biochemical factors such as hormones, growth factors, adenosine triphosphate (ATP) and its derivatives, and neuromodulators. The primary cilium also plays a key role in the detection of mechanical signals. During development, transforming growth factor-β (TGF-β), bone morphogenetic protein (BMP), and hedgehog (Hh) signaling modulate tendon differentiation and formation. The response to injury is complex and varied involving not only inflammatory mediators such as interleukin-1β but also mechanosensing. This chapter reviews the signaling pathways tenocytes use during mechanotransduction, development and in response to injury.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Wall ME,Dyment NA,Bodle J,Volmer J,Loboa E,Cederlund A,Fox AM,Banes AJdoi
10.1007/978-3-319-33943-6_7subject
Has Abstractpub_date
2016-01-01 00:00:00pages
79-95eissn
0065-2598issn
2214-8019journal_volume
920pub_type
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