Baroreflex control of heart rate and renin release in SHR following administration of felodipine, an antihypertensive Ca2+ antagonist.

abstract：:The effects of bufuralol and its carbinol metabolite have been compared with those of propranolol in the anaesthetised and conscious cat and dog. Bufuralol and its carbinol metabolite are nonselective beta-adrenoceptor antagonists; the former has equivalent potency to propranolol, whereas the latter is six times more ...

journal_title：Journal of cardiovascular pharmacology

authors： Blaber LC,Burden DT,Eigenmann R,Gerold M

更新日期：1984-01-01 00:00:00

abstract：:Pro-arrhythmia by noncardiac drugs has become an important safety concern in the pharmaceutical industry. The most common underlying mechanism for induction of arrhythmias by noncardiac drugs is off-target block of the native cardiac repolarizing current, I Kr. The pore-forming subunit of I Kr is encoded by the human ...

journal_title：Journal of cardiovascular pharmacology

authors： Margulis M,Sorota S

更新日期：2008-06-01 00:00:00

abstract：:Dimethyl sulfoxide (DMSO) is a widely used vehicle for water-insoluble substances and exerts a wide range of pharmacologic effects including anti-inflammatory and free radical scavenging properties. Additionally, in an animal model, DMSO inhibited cholesterol-induced atherosclerosis. Despite such profound pharmacologi...

journal_title：Journal of cardiovascular pharmacology

authors： Laskar A,Yuan XM,Li W

更新日期：2010-09-01 00:00:00

abstract：:The concentrations of lactate, pyruvate, and adenosine, together with some of their derivatives, were determined in microdialysates from 12 pig hearts, 6 of which were subjected to preconditioning and 40 min of ischemia (index ischemia) and 6 of which were subjected to only 40 min of index ischemia. Two microdialysis ...

journal_title：Journal of cardiovascular pharmacology

authors： Wikström BG,Ronquist G,Waldenström A

更新日期：1996-05-01 00:00:00

abstract：:Inflammation plays a central role in the pathogenesis of atherosclerosis. This study investigated whether the proteasome inhibitor has the same preventive effect on the formation of accelerated atherosclerosis in rabbits with uremia compared with a NF-kappaB inhibitor. New Zealand white rabbits were subjected to five-...

journal_title：Journal of cardiovascular pharmacology

authors： Feng B,Zhang Y,Mu J,Ye Z,Zeng W,Qi W,Luo Z,Guo Y,Yang X,Yuan F

更新日期：2010-02-01 00:00:00

abstract：:Sixteen nonhospitalized men, average age 41.3 years with essential hypertension (WHO I-II) were given nifedipine slow-release tablets of 20 mg twice daily for 48 weeks. Both supine and standing blood pressure values were significantly reduced, but heart rate was not significantly changed by the drug. A significant dec...

journal_title：Journal of cardiovascular pharmacology

authors： Landmark K

更新日期：1985-01-01 00:00:00

abstract：:BMY 20064 is a dihydropyridine Ca2+ entry blocker with potent and selective alpha 1-adrenoceptor antagonist properties. The drug was equal in potency to nifedipine as a Ca2+ entry blocker in depolarized smooth muscle preparations. It was less active than nifedipine in antagonizing Ca2+-induced contractions of isolated...

journal_title：Journal of cardiovascular pharmacology

authors： Stanton HC,Rosenberger LB,Hanson RC,Fleming JS,Poindexter GS

更新日期：1988-04-01 00:00:00

abstract：:We used strips of human pulmonary arteries from patients undergoing surgery for lung tumor to investigate whether or not this human tissue (like that of the rabbit) is endowed with inhibitory presynaptic alpha 2-adrenoceptors. The strips were incubated with [3H]noradrenaline and subsequently superfused with physiologi...

journal_title：Journal of cardiovascular pharmacology

authors： Hentrich F,Göthert M,Greschuchna D

更新日期：1986-05-01 00:00:00

abstract：:We recently found that TGF-beta increases ET-1 secretion in MDCK, a renal tubular cell line. The secretion of ET-1, by a confluent monolayer of MDCK cells grown on a filter, to the basolateral side of the epithelium was two times greater than that to the apical side. However, TGF-beta-increased ET-1 and big ET-1 secre...

journal_title：Journal of cardiovascular pharmacology

authors： Uchida S,Horie M,Yanagisawa M,Matsushita Y,Kurokawa K,Ogata E

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:Adequate folate status supports endothelial structure and function. Folic acid (FA), an oxidized synthetic folate, which is present in the plasma of patients consuming fortified food or FA supplements, may impair cellular uptake of physiological, reduced folates. We studied the effect of FA on uptake of the ...

journal_title：Journal of cardiovascular pharmacology

authors： Smith D,Hornstra J,Rocha M,Jansen G,Assaraf Y,Lasry I,Blom H,Smulders YM

更新日期：2017-10-01 00:00:00

abstract：:The effect of two dihydropyridine derivatives, nifedipine and felodipine, on myocardial blood flow distribution 1 h after ligation of the left anterior descending coronary artery (LAD) was studied in open-chest dogs by means of radioactive microspheres. The myocardium normally perfused from the LAD was first labeled w...

journal_title：Journal of cardiovascular pharmacology

authors： Sjöquist PO,Duker G,Almgren O

更新日期：1985-07-01 00:00:00

abstract：:Measurements of cerebrospinal fluid (CSF) catecholamines (CA) were made in an attempt to estimate the activity of central CA neurons in essential hypertension (EHT). CSF norepinephrine (NE), epinephrine (EPI), and dopamine (DA) levels were measured in 12 normotensive (age 36 +/- 3 years; SBP = 116 +/- 4 and DBP = 79 +...

journal_title：Journal of cardiovascular pharmacology

authors： Cubeddu LX,Hoffman IS

更新日期：1987-01-01 00:00:00

abstract：:The objective this investigation was to determine the relative importance of type I, III, and IV phosphodiesterases in the regulation of cyclic adenosine monophosphate (cAMP) in the renal circulation. In the first experimental series, four groups of isolated rat kidneys perfused with Tyrode's solution were stimulated ...

journal_title：Journal of cardiovascular pharmacology

authors： Jackson EK,Mi Z,Carcillo JA,Gillespie DG,Dubey RK

更新日期：1997-12-01 00:00:00

abstract：:During ischemia-reperfusion an imbalance between endothelin (ET) and nitric oxide (NO) can be responsible for microcirculatory disturbances. The aim of this study was to restore the ET/NO balance to reduce the ischemia-reperfusion injury. Hepatic ischemia was induced for 30 min in 56 Wistar rats. Sham operation, ische...

journal_title：Journal of cardiovascular pharmacology

authors： Uhlmann D,Uhlmann S,Spiegel HU

更新日期：2000-11-01 00:00:00

abstract：:We investigated the effects of a newly synthesized dihydropyridine (DHP) derivative (NZ-105) on intracellular Ca transients and contraction in ferret ventricular muscles, using the aequorin method. Low concentrations of NZ-105 (10(-9)-10(-7) M) showed no significant effects on the light signal of aequorin and tension ...

journal_title：Journal of cardiovascular pharmacology

authors： Kurihara S,Hongo K,Tanaka T,Tanaka E

更新日期：1994-08-01 00:00:00

abstract：:Cerebral ischemia has previously been shown to cause a systemic decrease in levels of the reduced forms of low-molecular-weight aminothiols [cysteine (Cys), homocysteine (Hcy), and glutathione (GSH)] in blood plasma. In this study, we examined the effect of beta-adrenergic receptor (β-AR) antagonists metoprolol (Met) ...

journal_title：Journal of cardiovascular pharmacology

authors： Ivanov AV,Alexandrin VV,Paltsyn AA,Virus ED,Nikiforova KA,Bulgakova PO,Sviridkina NB,Svetlana Alexandrovna Apollonova,Kubatiev AA

更新日期：2018-10-01 00:00:00

abstract：:During the last few years, there has been a growing awareness that treated hypertensive patients are still at substantially increased risks for cardiovascular morbidity and mortality and that one conceivable explanation for this is that their blood pressure has not been lowered to strictly normotensive levels. To obta...

journal_title：Journal of cardiovascular pharmacology

authors： Dahlöf B,Eggertsen R,Hansson L

更新日期：1988-01-01 00:00:00

abstract：:Genetic hypertension [essential hypertension (EH) in humans and spontaneous hypertension in rats (SHRs)] is associated with an altered vascular structure, expressed in resistance vessels (small arteries) as an increased media:lumen ratio. The vascular smooth muscle cells appear normal and there is no cellular hypertro...

journal_title：Journal of cardiovascular pharmacology

authors： Mulvany MJ

更新日期：1992-01-01 00:00:00

abstract：:To investigate the effects of ramipril, a new angiotensin converting enzyme inhibitor, on autonomic function, autonomic function tests were performed in eight healthy male subjects, aged 22-26 years, after single oral administration of 5 mg of ramipril or placebo, in a randomized, double-blind, crossover design. Measu...

journal_title：Journal of cardiovascular pharmacology

authors： Sugimoto K,Kumagai Y,Tateishi T,Seguchi H,Ebihara A

更新日期：1989-01-01 00:00:00

abstract：:We investigated the characteristics of 125I-AII binding to rat adrenal and bovine cerebellar membranes in the presence and absence of new nonpeptide angiotensin II (AII) receptor ligands. The imidazole AII ligands, DUP753 and WL19, both produced biphasic competition curves to 125I-AII binding in rat adrenal glomerulos...

journal_title：Journal of cardiovascular pharmacology

authors： Wiest SA,Rampersaud A,Zimmerman K,Steinberg MI

更新日期：1991-02-01 00:00:00

abstract：:Inhibition of angiotensin-converting enzyme (ACEI) after myocardial infarction reduces remodeling of the surviving myocardium. The cellular signaling mechanisms contributing to remodeling are not fully elucidated. Goal of the current study was to test whether protein kinase C (PKC) is regulated in the surviving myocar...

journal_title：Journal of cardiovascular pharmacology

authors： Simonis G,Braun MU,Kirrstetter M,Schön SP,Strasser RH

更新日期：2003-05-01 00:00:00

abstract：:In urban Australia, the risk of retiring with hypertension is greater than 40%, and the basic abnormality--a rise in blood pressure (BP) with age--is almost universal. A hypothesis linking this with salt, therefore, concerns everyone. The diet of early humans was unsalted, and the Na content of breast milk (6 mmol/kg)...

journal_title：Journal of cardiovascular pharmacology

authors： Beard TC

更新日期：1990-01-01 00:00:00

abstract：:Felodipine, a dihydropyridine calcium antagonist, was used to treat eight patients with severe uncontrolled hypertension: five had essential hypertension, two had renovascular disease, and one chronic pyelonephritis. Mean blood pressure (BP) was 221 +/- 14/120 +/- 4 mm Hg despite treatment with three or more antihyper...

journal_title：Journal of cardiovascular pharmacology

authors： Herlitz H,Granérus G,Aurell M

更新日期：1990-01-01 00:00:00

abstract：:To clarify the characteristics of KC-399, a newly synthesized potassium channel opener, we investigated the effects of KC-399 and lemakalim on the contractions induced by norepinephrine (NE 1 microM) and K+ (30 and 90 mM) and on 86Rb efflux in rat thoracic aorta. KC-399 (0.01-10 nM) and lemakalim (0.001-10 microM) ind...

journal_title：Journal of cardiovascular pharmacology

authors： Tamura K,Suzuki Y,Yoshida S,Nabata H

更新日期：1994-02-01 00:00:00

abstract：:The elimination of an acute oral saline load is markedly blunted in adult Sabra hypertension-prone (SBH) rats compared with hypertension-resistant Sabra normotensive (SBN) rats. Within 2 h, urinary output and the excretion of sodium and potassium are significantly reduced, while urine osmolality is markedly elevated i...

journal_title：Journal of cardiovascular pharmacology

authors： Mekler J,Ben-Ishay D,Garthoff B,Kazda S

更新日期：1987-01-01 00:00:00

abstract：:The antihypertensive effects and pharmacokinetic properties of lisinopril, an angiotensin-converting enzyme (ACE) inhibitor, were investigated in hypertensive patients with normal renal function (NRF, mean serum creatinine 1.0 mg/dl, n = 9) and those with impaired renal function (IRF, mean serum creatinine 1.7 mg/dl, ...

journal_title：Journal of cardiovascular pharmacology

authors： Shionoiri H,Minamisawa K,Ueda S,Abe Y,Ebina T,Sugimoto K,Matsukawa T,Gotoh E,Ishii M

更新日期：1990-10-01 00:00:00

abstract：:The hypotensive effects of ketanserin, a selective blocker of 5-hydroxytryptamine2, are well defined, but its electrophysiologic effects in humans are not. Intravenous ketanserin (0.15 mg/kg) was therefore given to 10 patients undergoing electrophysiologic evaluation, and data were obtained before and after drug admin...

journal_title：Journal of cardiovascular pharmacology

authors： Nademanee K,Lockhart E,Pruitt C,Singh BN

更新日期：1987-01-01 00:00:00

abstract：:The majority of patients with implanted cardioverter defibrillators (ICD) require antiarrhythmic (AR) drugs. ARs may increase defibrillation energy requirements. This study investigated the effects of lidocaine, ajmaline, and diltiazem on ventricular defibrillation energy needs. In 24 isolated rabbit hearts, the 50 an...

journal_title：Journal of cardiovascular pharmacology

authors： Anvari A,Mast F,Schmidinger H,Schuster E,Allessie M

更新日期：1997-04-01 00:00:00

abstract：:The effects of SIN-1 were studied on isolated aortic rings and perfused hindquarters of the rat and were compared with the effects of nitroglycerin and endothelium-derived relaxing factor (EDRF) released by acetylcholine or histamine (aorta) and carbachol (hindquarters). SIN-1 relaxes rat aortic rings in a dose-depend...

journal_title：Journal of cardiovascular pharmacology

authors： Van de Voorde J,Claeys M,Leusen I

更新日期：1989-01-01 00:00:00

abstract：:Nineteen hypertensive patients were treated with increasing doses of the new angiotensin-converting enzyme inhibitor MK 421. Twenty milligrams orally reduced blood pressure from 180/112 +/- 6.8/3.6 (mean +/- SEM) to 160/100 +/- 6.5/3.3 mm Hg (p less than 0.005) while heart rate increased from 75 +/- 2 to 87 +/- 3 beat...

journal_title：Journal of cardiovascular pharmacology

authors： Biollaz J,Brunner HR,Gavras I,Waeber B,Gavras H

更新日期：1982-11-01 00:00:00