Abstract:
:Southern blot hybridization with the Ca3 probe and the C fragment of the Ca3 probe was used to assess the genetic relatedness of Candida albicans strains from one patient with recurrent C. albicans infection in whom the same strain was maintained, one patient in whom the infecting strain was replaced, and their male sexual partners. In the patient in whom the infecting strain was maintained, the infecting strain exhibited a minor genetic change in each successive episode of Candida vaginitis. These genetic changes occurred in the C-fragment bands of the Ca3 hybridization pattern. In the patient in whom the infecting strain was replaced by another infecting strain, a transition infection involved a genetically mixed infecting population, and the replacement strain appeared to have originated from the oral cavity of the male partner. The results demonstrate that the infecting strains of recurrent Candida vaginitis are not genetically stable, that drug treatment can result in the selection of variants of the previously infecting strain or replacement by a genetically unrelated strain, and that the male partner can be the source of a replacement strain.
journal_name
J Clin Microbioljournal_title
Journal of clinical microbiologyauthors
Schröppel K,Rotman M,Galask R,Mac K,Soll DRdoi
10.1128/JCM.32.11.2646-2654.1994subject
Has Abstractpub_date
1994-11-01 00:00:00pages
2646-54issue
11eissn
0095-1137issn
1098-660Xjournal_volume
32pub_type
杂志文章abstract::Pneumococcal surface protein A (PspA) has been considered a potential candidate for human vaccines because of its serotype-independent protective immunity. Nasopharyngeal (NP) pneumococcal colonization is highly prevalent in infants and precedes the invasive disease. Thus, prevention of NP colonization may reduce the ...
journal_title:Journal of clinical microbiology
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更新日期:2006-08-01 00:00:00
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journal_title:Journal of clinical microbiology
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doi:10.1128/JCM.31.1.39-46.1993
更新日期:1993-01-01 00:00:00
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journal_title:Journal of clinical microbiology
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doi:10.1128/JCM.28.10.2183-2186.1990
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doi:10.1128/JCM.25.3.559-562.1987
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doi:10.1128/JCM.39.12.4452-4455.2001
更新日期:2001-12-01 00:00:00
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journal_title:Journal of clinical microbiology
pub_type: 杂志文章
doi:
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journal_title:Journal of clinical microbiology
pub_type: 杂志文章
doi:10.1128/JCM.32.11.2702-2705.1994
更新日期:1994-11-01 00:00:00
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journal_title:Journal of clinical microbiology
pub_type: 杂志文章
doi:10.1128/JCM.37.10.3370-3373.1999
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更新日期:1995-12-01 00:00:00
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journal_title:Journal of clinical microbiology
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doi:10.1128/JCM.30.12.3168-3174.1992
更新日期:1992-12-01 00:00:00
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journal_title:Journal of clinical microbiology
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更新日期:1988-03-01 00:00:00
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journal_title:Journal of clinical microbiology
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更新日期:1990-11-01 00:00:00
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更新日期:2009-08-01 00:00:00
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journal_title:Journal of clinical microbiology
pub_type: 杂志文章
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更新日期:1994-05-01 00:00:00
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journal_title:Journal of clinical microbiology
pub_type: 杂志文章
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更新日期:1980-03-01 00:00:00
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journal_title:Journal of clinical microbiology
pub_type: 杂志文章
doi:
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