Characterization of and protection from neurotoxicity induced by oxaliplatin, bortezomib and epothilone-B.

abstract：BACKGROUND:Heterodimer cooperation between ErbB receptors has limited clinical usefulness of receptor tyrosine kinase inhibitors (TKIs), erlotinib and gefitinib in the treatment of cancer. However, combination treatment of TKIs with gamma-tocotrienol targets multiple ErbB receptors and significantly inhibit +SA murine ...

journal_title：Anticancer research

authors： Bachawal SV,Wali VB,Sylvester PW

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND/AIM:Cancer incidence and mortalities are growing worldwide, therefore research and development of more effective and less invasive treatments, such as photodynamic therapy, are needed. Herein, we investigated the methylene blue (MB) photoactivation effects in lung epithelial cells (BEAS-2B) and lung adenocar...

journal_title：Anticancer research

authors： Rodríguez-Córdova RJ,Gutiérrez-Valenzuela CA,Bojang P,Esquivel R,Hernández P,Ramos KS,Guzmán-Zamudio R,Lucero-Acuña A

更新日期：2019-07-01 00:00:00

abstract：:Dendritic cells (DCs) are professional antigen presenting cells. Two x 10(7) peripheral blood mononuclear cells (PBMCs) from each of 6 melanoma patients and 4 normal donors were incubated in 6-well plates. The adherent cells were cultured in GM-CSF (800 U/ml) and IL-4 (1000 U/ml) for 10 days. Anti-CD80, anti-CD86, ant...

journal_title：Anticancer research

authors： Chang JW,Vaquerano JE,Zhou YM,Peng M,Leong SP

更新日期：1999-05-01 00:00:00

abstract：AIM:To evaluate the efficacy and toxicities of cisplatin and daily oral etoposide in patients with recurrent cervical cancer. PATIENTS AND METHODS:Treatment was initiated with oral etoposide 25 mg/day for 21 consecutive days, with intravenous cisplatin at 50 mg/m², on day 1, every 4 weeks, then the etoposide dose was ...

journal_title：Anticancer research

authors： Watanabe Y,Hoshiai H,Nakanishi T,Kawamura N,Tanaka N,Isaka K,Kamiura S,Ohmichi M,Hatae M,Ochiai K

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND/AIM:γ-Glutamylcyclotransferase (GGCT), a key enzyme involved in glutathione metabolism, catalyzes a specific reaction that generates 5-oxoproline and free amino acids from the γ-glutamyl peptide. Inhibition of GGCT is a promising therapeutic strategy for the treatment of various cancers. MATERIALS AND METHO...

journal_title：Anticancer research

authors： Hanada E,Kageyama S,Murai R,Kubota S,Ii H,Nakata S,Kita H,Kawauchi A,Chano T

更新日期：2019-04-01 00:00:00

abstract：:Since the discovery of cisplatin about 40 years ago, the design of innovative metal-based anticancer drugs is a growing area of research. Transition metal coordination complexes offer potential advantages over the more common organic-based drugs, including a wide range of coordination number and geometries, accessible...

journal_title：Anticancer research

authors： Pottier A,Borghi E,Levy L

更新日期：2014-01-01 00:00:00

abstract：AIM:We analyzed pentafecta outcomes [complication-free, continence, potency, negative surgical margins (NSM)], biochemical recurrence (BCR)-free] of 230 patients undergoing robotic-assisted radical prostatectomy (RARP) with bilateral neurovascular (NVB) preservation. PATIENTS AND METHODS:Patient outcomes (group I, cas...

journal_title：Anticancer research

authors： Ou YC,Yang CK,Kang HM,Chang KS,Wang J,Hung SW,Tung MC,Tewari AK,Patel VR

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:DeltaNp63 is an isoform of the p53 homolog p63, which lacks an amino-terminal transactivation domain. The aim of this study was to detect the deltaNp63 expression in the squamous carcinoma component of adenosquamous carcinoma and evaluate its usefulness as a specific squamous carcinoma marker. PATIENTS AND ...

journal_title：Anticancer research

authors： Uramoto H,Yamada S,Hanagiri T

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND/AIM:We performed a phase II study of triple-drug combination chemoradiotherapy (DCF-R therapy), in which docetaxel was added to the standard chemoradiotherapy (cisplatin [CDDP]/5-fluorouracil [5-FU]) for unresectable advanced esophageal cancer. PATIENTS AND METHODS:Sixty-one patients with unresectable advan...

journal_title：Anticancer research

authors： Takahashi K,Osaka Y,Ota Y,Watanabe T,Iwasaki K,Tachibana S,Nagakawa Y,Katsumata K,Tsuchida A

更新日期：2020-05-01 00:00:00

abstract：:The expression of the proto-oncogene c-myc has been strongly implicated in the regulation of apoptosis. Since we have previously shown apoptosis to occur in HL-60 leukemic cells exposed to the prodrug Mafosfamide (ASTA Z 7557), the present study was undertaken to examine the levels of c-myc mRNA transcripts in such ce...

journal_title：Anticancer research

authors： Davidoff AN,Mendelow BV

更新日期：1993-07-01 00:00:00

abstract：:When mouse resident peritoneal macrophages were cultured with PSK (Krestin), a protein-bound polysaccharide extracted from Coriolus versicolor, they became enlarged and elongated and expressed higher NBT-reducing activity. PSK stimulated the production of differentiation-inducing factor and cytotoxic factor by the mou...

journal_title：Anticancer research

authors： Kurakata Y,Sakagami H,Sato A,Kikuchi K,Takeda M,Asano K,Sato T

更新日期：1991-09-01 00:00:00

abstract：AIM:To evaluate the tolerability and efficacy of oxaliplatin-based chemotherapy (OBC) in patients ≥ 75 years old with metastatic colorectal cancer (CRC). PATIENTS AND METHODS:We reviewed the medical records of 126 patients with unresectable stage IV CRC in terms of OBC administered as first-line chemotherapy whenever ...

journal_title：Anticancer research

authors： Fukuchi M,Ishibashi K,Tajima Y,Okada N,Yokoyama M,Chika N,Hatano S,Matsuzawa T,Kumamoto K,Kumagai Y,Baba H,Mochiki E,Ishida H

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:One of the major changes in the new TNM classification (5th edition, 1997) for gastric cancer was made in the classification of N category: the 5th edition employs the number of involved nodes and a minimum of 15 examined nodes is required for N0 classification. The validity of the new TNM classification was...

journal_title：Anticancer research

authors： Nio Y,Yamasawa K,Yamaguchi K,Itakura M,Omori H,Koike M,Kitamura Y,Tsuji M,Endo S,Ogo Y,Yano S,Sumi S

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Alterations of mitochondrial DNA (mtDNA) have been found in cancer patients, therefore informative mtDNA mutations could serve as biomarkers for the disease. MATERIALS AND METHODS:The two hypervariable regions HVR1 and HVR2 in the D-Loop region were sequenced in ten paired tissue and plasma samples from bre...

journal_title：Anticancer research

authors： Cai FF,Kohler C,Zhang B,Chen WJ,Barekati Z,Garritsen HS,Lenner P,Toniolo P,Zhang JJ,Zhong XY

更新日期：2011-12-01 00:00:00

abstract：UNLABELLED:BACKGROUD/AIM: We previously demonstrated that high protein expression of excision repair cross-complementation group-1 (ERCC1) was associated with poor disease-free survival in patients who received adjuvant cisplatin-based chemotherapy or chemoradiotherapy with cisplatin, and was shown to be an independent...

journal_title：Anticancer research

authors： Torii Y,Kato R,Minami Y,Hasegawa K,Fujii T,Udagawa Y

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:The frequency of epithelial cell adhesion molecule (EpCAM) expression was investigated in non-small cell lung cancer (NSCLC) cells and human tissues, and its clinicopathological significance in adenocarcinoma of the lung was evaluated. MATERIALS AND METHODS:EpCAM expression was analysed by reverse transcrip...

journal_title：Anticancer research

authors： Kim Y,Kim HS,Cui ZY,Lee HS,Ahn JS,Park CK,Park K,Ahn MJ

更新日期：2009-05-01 00:00:00

abstract：:The multifaceted involvement of the active vitamin D metabolite 1,25-dihydroxyvitamin D3 (henceforth referred to by the synonyms 1,25(OH)2D3, calcitriol or vitamin D) in blunting the growth of cancer cells is amply recognized. In this review we focused our attention on the cross-talk between 1,25 (OH)2D3 and the tumor...

journal_title：Anticancer research

authors： Shany S,Sigal-Batikoff I,Lamprecht S

更新日期：2016-12-01 00:00:00

abstract：:We describe the case of an 80-year-old man with hepatocellular carcinoma (HCC) who developed tracheal obstruction due to peritracheal lymph node metastasis. A metastatic tumor that protruded into the airway was ablated using a neodymium yttrium-aluminium-garnet laser and then a self-expandable metallic stent (SEMS) wa...

journal_title：Anticancer research

authors： Hamai Y,Hihara J,Aoki Y,Taomoto J,Kishimoto I,Kobayashi Y,Miyata Y,Aikata H,Chayama K,Okada M

更新日期：2013-04-01 00:00:00

abstract：:Thirty advanced breast cancer patients received Vinorelbine (VNB) according to two different schedules: a weekly i.v. bolus of 30 mg/m (14 patients) or a continuous infusion (CI) schedule comprising 8 mg i.v. bolus on day 1 followed by 8 mg/m2/die CI day 1 to 4, q 21 days (16 patients). 36% of patients had received at...

journal_title：Anticancer research

authors： Gasco M,Gardin G,Repetto L,Campora E,Rosso R

更新日期：1997-03-01 00:00:00

abstract：:The use of lysozyme preparations in the treatment of tumor diseases is based on more than 30 years' experience, using different methodologies and showing various results from which suggestions on the mechanism of action were derived. Lysozymes have no established place in the treatment of human tumors in spite of some...

journal_title：Anticancer research

authors： Sava G,Benetti A,Ceschia V,Pacor S

更新日期：1989-05-01 00:00:00

abstract：:Intratumoral (cervix uterine tumors) distribution of platinum was studied in ten patients after IV administration of CDDP. Sequential tumoral measurement of platinum was carried out 4, 24, and 48 h after the IV infusion. Platinum concentration in the tumor samples ranged from 0 to 29,5 ng/mg tissue. For all patients, ...

journal_title：Anticancer research

authors： Vennin P,Hecquet B,Fournier C,Demaille MC,Adenis L

更新日期：1985-07-01 00:00:00

abstract：:For the determination of LDL receptor expression on living human cells two monoclonal antibodies specific for the extracellular domain of LDL receptor were established using affinity-purified LDL receptor and carrier-conjugated LDL receptor peptide 163-174 as immunizing antigens. The 125I-labeled antibodies were used ...

journal_title：Anticancer research

authors： Menrad A,Anderer FA

更新日期：1991-01-01 00:00:00

abstract：:Gallic acid induced apoptotic cell death in human promyelocytic leukemia HL-60 cells. The effect of gallic acid was significantly reduced by blocking the free hydroxyl or carboxyl group with acetyl, methyl, ethyl, n-propyl or isoamyl group. This was paralleled with the decrease in the intensity of both gallate radical...

journal_title：Anticancer research

authors： Sakagami H,Satoh K,Hatano T,Yoshida T,Okuda T

更新日期：1997-01-01 00:00:00

abstract：:Giant cell tumor (GCT) is a relatively common and locally aggressive benign bone tumor. The sternum is a rare location. To date, only four cases have been reported with detailed information. Here, we present a case with sternal GCT and discuss the clinical manifestation and treatment, in addition to reviewing the lite...

journal_title：Anticancer research

authors： Futani H,Okumura Y,Fukuda Y,Fukunaga S,Hasegawa S,Yoshiya S

更新日期：2008-11-01 00:00:00

abstract：:This epidemiological study was performed to evaluate the influence of postoperative complementary treatment with lectin-standardized mistletoe extract (sME) on breast cancer patients. The design (retrolective cohort analysis with parallel groups) and conduct of the study were in agreement with current standards for pr...

journal_title：Anticancer research

authors： Schumacher K,Schneider B,Reich G,Stiefel T,Stoll G,Bock PR,Hanisch J,Beuth J

更新日期：2003-11-01 00:00:00

abstract：:Various lignified materials, including pine cone extract and a commercial lignin, stimulated the morphological change (spreading) of mouse peritoneal macrophages, and their functional maturation as judged by increase in NBT-reducing activity. When these materials were treated with NaClO2 to decompose the phenolic stru...

journal_title：Anticancer research

authors： Kikuchi K,Sakagami H,Fujinaga S,Kawazoe Y,Oh-Hara T,Ichikawa S,Kurakata Y,Takeda M,Sato T

更新日期：1991-03-01 00:00:00

abstract：BACKGROUND:Warthin-like mucoepidermoid carcinoma is a newly recognized rare entity and could be misdiagnosed as a benign Warthin tumor. We report such a case of a 36-year-old male who presented with a left parotid gland mass. CASE REPORT:Fine-needle aspiration showed features suggestive of Warthin tumor. Following par...

journal_title：Anticancer research

authors： Zhang D,Liao X,Tang Y,Meyer RG,VAN Dyke DL,Liu X,Islam MN,Lai J

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND/AIM:To describe real clinical outcomes when using systemic therapy to treat non-small cell lung cancer (NSCLC) patients who have anaplastic lymphoma kinase (ALK) fusion gene mutation. PATIENTS AND METHODS:We performed a retrospective chart review from April 2008 to March 2019 sourced from 16 medical institu...

journal_title：Anticancer research

authors： Okauchi S,Numata T,Nawa T,Ichimura H,Saito T,Hayashihara K,Yamada H,Satoh H,Endo T,Inage Y,Kaburagi T,Kiyoshima M,Yamada Y,Tamura T,Saito K,Inagaki M,Hizawa N,Sato Y,Shiozawa T,Sekine I,Ishikawa H,Kurihima K,S

更新日期：2020-02-01 00:00:00

abstract：:In screening cytotoxic agents in morphine alkaloids [TE1-10], codeinone [TE8] was cytotoxic against two human oral tumor cells lines (HSC-2 and HSG). The cytotoxic activity of codeinone (CC50=1.0-1.2 microg/mL) against HSC-2 or HSG cells was higher than that of doxorubicin (CC50=1.9-2.0 microg/mL). Human oral gingival...

journal_title：Anticancer research

authors： Kawase M,Sakagami H,Furuya K,Kikuchi H,Nishikawa H,Motohashi N,Morimoto Y,Varga A,Molnár J

更新日期：2002-01-01 00:00:00

abstract：:Adrenocortical carcinoma (ACC) is a rare neoplasm with a poor prognosis. Prognostic factors are needed to identify patients who should be treated aggressively and those for which a less aggressive approach is warranted. As a result of advances within the field of immunohistochemistry, investigations of Ki-67, PCNA, IG...

journal_title：Anticancer research

authors： Edgren M,Eriksson B,Wilander E,Westlin JE,Nilsson S,Oberg K

更新日期：1997-03-01 00:00:00