Acute stroke: evaluation with serial proton MR spectroscopic imaging.

Abstract:

PURPOSE:To investigate the evolution of metabolic changes detectable with proton magnetic resonance (MR) spectroscopic imaging in acute stroke and to compare these findings with those of conventional MR imaging. MATERIALS AND METHODS:A patient with middle cerebral artery stroke underwent conventional proton-density (PD)- and T2-weighted MR imaging, MR angiography, and multisection proton two-dimensional MR spectroscopic imaging over a period of 3 hours to 5 months after symptom onset. RESULTS:On 3-hour MR images, no abnormal signal intensity change was detectable. Spectroscopic images obtained at 24 hours showed localized elevation of cerebral lactate levels. In most regions with high lactate levels, infarction subsequently occurred. In the chronic stage (5 months), the infarct was associated with reduced N-acetylaspartate levels, increased choline levels, and absence of lactate. CONCLUSION:Spectroscopic imaging enables mapping of ischemic and infarcted brain regions with greater sensitivity than does conventional MR imaging.

journal_name

Radiology

journal_title

Radiology

authors

Barker PB,Gillard JH,van Zijl PC,Soher BJ,Hanley DF,Agildere AM,Oppenheimer SM,Bryan RN

doi

10.1148/radiology.192.3.8058940

subject

Has Abstract

pub_date

1994-09-01 00:00:00

pages

723-32

issue

3

eissn

0033-8419

issn

1527-1315

journal_volume

192

pub_type

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