3H-naloxone binding in brain regions of normotensive Wistar, spontaneously hypertensive and renal hypertensive rats.

Abstract:

:In order to study the role of opioid receptors in two models of experimental hypertension the binding of 3H-naloxone to membranes prepared from discrete brain regions and spinal cord was determined. Renal hypertensive rats (RHR) were found to have a greater density of 3H-naloxone binding sites in the hippocampus and hypothalamus when compared to spontaneously hypertensive rats (SHR) and normotensive Wistar rats (NR). The apparent dissociation constant (Kd) for 3H-naloxone binding did not differ between groups.

journal_name

Blood Press

journal_title

Blood pressure

authors

Widy-Tyszkiewicz E,Kotapski J,Czlonkowski A

doi

10.3109/08037059409102254

subject

Has Abstract

pub_date

1994-05-01 00:00:00

pages

202-5

issue

3

eissn

0803-7051

issn

1651-1999

journal_volume

3

pub_type

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