FUT2: filling the gap between genes and environment in Behçet's disease?

Abstract:

OBJECTIVES:To identify new susceptibility loci for Behçet's disease (BD), we performed a genome-wide association study (GWAS) using DNA pooling. METHODS:Two replicate pools of 292 Iranian BD cases and of 294 age- and sex-matched controls were allelotyped in quadruplicate on the Affymetrix Genome-Wide Human SNP Array 6.0. Of the 51 top markers, 47 were technically validated through individually genotyping. Replication of validated single nucleotide polymorphisms (SNPs) was performed in an independent Iranian dataset (684 cases and 532 controls). RESULTS:In addition to the well-established HLA-B locus, rs7528842 in a gene desert on chromosome 1p21.2, and rs632111 at the 3'UTR of FUT2 were associated in both the discovery and replication datasets (individually and in combination). However, only the FUT2 SNP was associated in a previous GWAS for BD in Turkish people. Fine-mapping of FUT2 in the full Iranian dataset showed additional associations in five coding SNPs (2.97E-06

journal_name

Ann Rheum Dis

authors

Xavier JM,Shahram F,Sousa I,Davatchi F,Matos M,Abdollahi BS,Sobral J,Nadji A,Oliveira M,Ghaderibarim F,Shafiee NM,Oliveira SA

doi

10.1136/annrheumdis-2013-204475

subject

Has Abstract

pub_date

2015-03-01 00:00:00

pages

618-24

issue

3

eissn

0003-4967

issn

1468-2060

pii

annrheumdis-2013-204475

journal_volume

74

pub_type

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