Abstract：
PURPOSE:To delineate and discuss a not yet described possible ocular complication of selective intra-arterial chemotherapy (SIAC) for treatment of retinoblastoma. METHODS:A 23-month-old girl with a large unilateral retinoblastoma was treated with repeated SIAC using 5 mg melphalan between July 2010 and January 2012. Clinical course of tumor and further ocular changes after therapy and histopathologic findings are described. RESULTS:In total, 5 SIAC were performed over a time period of 18 months. After the last SIAC, diffuse dense cataract prevented further funduscopy. In addition, anterior chamber seeding was obvious, leading to the decision to enucleate the eye. Histopathologically, nearly complete regression of the main tumor mass with prominent calcifications, but vital tumor seeding in the vitreous, on the lens surface, on the ciliary body, and in the anterior chamber, was observed. Peculiar vacuolation of the lens epithelial cells, liquefaction of the subepithelial lens fibers, and diffuse small vacuoles within the lens were striking. CONCLUSIONS:Repeated SIAC with melphalan may induce cataract formation, possibly as a toxic effect of the chemotherapeutic to the lens, maybe combined with radiation exposure during fluoroscopy. This ocular complication should be taken into consideration as a limitation of the number of feasible repeated treatments.
journal_name
Eur J Ophthalmoljournal_title
European journal of ophthalmologyauthors
Suesskind D,Schrader M,Foerster MH,Ernemann U,Aisenbrey Sdoi
10.5301/ejo.5000393subject
Has Abstractpub_date
2014-05-01 00:00:00pages
449-53issue
3eissn
1120-6721issn
1724-6016pii
F2EE21F9-30A0-4BCC-99D0-79C0D995C982journal_volume
24pub_type
杂志文章abstract：PURPOSE:To describe a new genetic variation of BEST1 gene in Best vitelliform macular dystrophy. METHODS:A patient with bilateral multiple retinal yellowish lesions at the posterior pole underwent fluorescein angiography, fundus autofluorescence, optical coherence tomography, electrooculogram and blood sample for gene...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/1120672120920536
更新日期：2020-04-22 00:00:00
abstract：PURPOSE:Retinopathy is the major cause of ocular morbidity in patients with diabetes mellitus. Chronic hyperglycemia spares no organ and can affect the morphology and function of the various corneal layers, compromising its transparency. This study was conducted to associate the status of corneal endothelium to diabete...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067210901900307
更新日期：2009-05-01 00:00:00
abstract：PURPOSE:To correlate conjunctival intercellular adhesion molecule 1 (ICAM-1) expression with cytologic and clinical findings of chronic graft-versus-host disease (GVHD). METHODS:Seven patients with chronic GVHD-related keratoconjunctivitis and five age-matched normal controls were recruited for the study. Clinical exa...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067210601600104
更新日期：2006-01-01 00:00:00
abstract：PURPOSE:To prospectively compare the clinical results of two cataract surgery procedures through a 4.0-mm incision, differing only in the wound location (superior or lateral). METHODS:168 eyes with cataract were randomly assigned to either procedure. Except for incision location, surgical methods were identical. Uncor...
journal_title：European journal of ophthalmology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1996-10-01 00:00:00
abstract：PURPOSE:To compare 2 different application methods of mitomycin C (MMC) in patients undergoing trabeculectomy. METHODS:This retrospective trial compared outcomes of 191 eyes that underwent trabeculectomy with small-area (96 eyes; 50.3%) and large-area (95 eyes; 49.7%) MMC application. Main outcome measures were chang...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.5301/ejo.5000287
更新日期：2013-09-01 00:00:00
abstract：PURPOSE:To describe the use of silicone oil (SO) in combination with subretinal recombinant tissue plasminogen activator (rtPA) to achieve dislocation of large subretinal hemorrhage secondary to exudative age-related macular degeneration (AMD). METHODS:A single-eye 81-year-old woman, known for exudative AMD, presented...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/1120672120952349
更新日期：2020-08-18 00:00:00
abstract：PURPOSE:To report a case of tubulointerstitial nephritis and uveitis syndrome (TINU syndrome) with unusual unilateral neuroretinitis. METHODS:An 11-year-old girl who developed anterior uveitis 3 months after acute tubulointerstitial nephritis, without any etiologic factors for either nephritis or uveitis, is presented...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：2004-07-01 00:00:00
abstract：PURPOSE:To evaluate perioperative changes in blood coagulation in patients undergoing retinal detachment surgery. MATERIALS:Prospective study of 56 patients, aged from 19 to 82 (mean +/- S.D. 53 +/- 16.8) years, undergoing retinal detachment surgery (encirclement with scleral buckling) under general anesthesia. Exclud...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067210001000408
更新日期：2000-10-01 00:00:00
abstract：PURPOSE:To verify the functional and anatomical results of retinal detachments related to choroidal coloboma. METHODS:Seven eyes with retinal detachment secondary to retinal breaks at the margin of or within a choroidal coloboma were analysed retrospectively. RESULTS:Scleral buckling was performed in five of the seve...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067210201200408
更新日期：2002-07-01 00:00:00
abstract：PURPOSE:This is a report of 2 cases of cutis aplasia and cutis marmorata telangiectasia with associated retinal detachment. METHODS:Retrospective case report. RESULTS:Illustration of ophthalmic associations of the rare congenital dermatologic presentations and description of successful treatment with laser photocoagu...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.5301/ejo.5000137
更新日期：2012-09-01 00:00:00
abstract：PURPOSE:To examine the association between Lp(a) concentrations and the severity of retinopathy in 22 younger-onset and 48 older-onset diabetic subjects from the Wisconsin Epidemiologic Study of Diabetic Retinopathy (WESDR), a population-based study of diabetic retinopathy. METHODS:We used a subset of the WESDR popula...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：1995-04-01 00:00:00
abstract：PURPOSE:To describe and compare long-term (> or = 36 months) effects of patients with 86 primary pterygia treated with bare sclera extirpation (BSE) followed by Beta-RT or by sham irradiation. METHODS:Prospective, multicenter, randomized, double-blind study. After BSE of their pterygium, patients were randomized to ei...
journal_title：European journal of ophthalmology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1177/112067210801800301
更新日期：2008-05-01 00:00:00
abstract：:Blood flow in various tissues of the body shows spontaneous variations. The purpose of this study was to analyze variations over time in the blood flow of the optic nerve head. Blood flow was measured by the laser Doppler flowmeter (LDF) in 12 healthy volunteers, and analyzed by spectral Fourier analysis. The LDF tech...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：1997-10-01 00:00:00
abstract：:To assess the utility of exfoliative cytology in the diagnosis of chronic conjunctivitis, we compared its findings with microbiological examination and established the correlation between cytology and microbiology in 32 patients with conjunctivitis lasting four weeks or more, with a nonspecific clinical picture. The m...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：OBJECTIVE:Riboflavin UVA (collagen crosslinking [CXL]) treatment for keratoconus is a method for stabilizing or improving corneal properties. Our aim was to evaluate changes in corneal topography indices after CXL. METHODS:A total of 38 eyes of 25 patients (mean age 29.36 ± 9.7 years) were treated with CXL technique...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.5301/ejo.5000249
更新日期：2013-09-01 00:00:00
abstract：PURPOSE:To report an unusual complication of treatment in the case of a Descemets membrane detachment. METHODS:Observational case report. RESULTS:A 79-year-old woman presented for elective cataract surgery. Ocular risk factors identified preoperatively included moderately shallow anterior chambers bilaterally, previo...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.5301/EJO.2008.5031
更新日期：2006-09-01 00:00:00
abstract：PURPOSE:Mutations in the ABCA4 gene result in a broad spectrum of severe retinal degeneration, including Stargardt macular dystrophy, fundus flavimaculatus, autosomal recessive retinitis pigmentosa, and cone-rod dystrophy. In addition to the detection of well-characterized mutations, genetic testing frequently yields n...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.5301/ejo.5001019
更新日期：2018-01-01 00:00:00
abstract：:The purpose of this study was to evaluate the hemodynamic changes occurring in the ophthalmic vasculature of eyes with Behçet's disease in a controlled clinical trial. Both eyes of patients with retinal involvement due to Behçet's disease were consecutively evaluated and were established as having mild or severe retin...
journal_title：European journal of ophthalmology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1997-07-01 00:00:00
abstract：PURPOSE:Preservatives in glaucoma medications have been associated with ocular toxicity. We compared ocular signs and symptoms in patients with open-angle glaucoma or ocular hypertension treated in monotherapy with preserved or preservative-free prostaglandin analogues. METHODS:Observational cross-sectional clinical s...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/1120672118805877
更新日期：2019-11-01 00:00:00
abstract：PURPOSE:To report a case of bilateral retinocytoma associated with calcified vitreous deposits. METHODS:Case report. RESULTS:On routine examination, a 35-year-old asymptomatic father of a child with bilateral retinoblastoma presented bilateral retinocytoma associated with vitreous calcifications, in the vicinity of t...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067210601600227
更新日期：2006-03-01 00:00:00
abstract：PURPOSE:To describe a strategy to reduce Covid-19 spread among healthcare workers and provide ophthalmologists with recommendations useful for a possible second wave of Covid-19 in Autumn. METHODS:Epidemiological surveillance at the Cà Foncello Hospital (Veneto, Italy) since 24 February 2020 to 24 April 2020 when the ...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/1120672120982520
更新日期：2020-12-15 00:00:00
abstract：PURPOSE:To evaluate the use of the resorbable polylactic acid polymer implants (Resorb X) in the management of orbital floor blow-out fractures as regards safety, cosmetic, and functional results. METHODS:In a prospective, interventional case series, 22 patients with traumatic blow-out floor fractures underwent lower ...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/1120672120928005
更新日期：2020-05-31 00:00:00
abstract：PURPOSE:To study the morphologic characteristics of the optic nerve (ON) by using an experimental model of knockout mice for the expression of the P27(Kip1) gene, mainly involved in cell cycle arrest, apoptosis control, and retinoblastoma protein phosphorylation. METHODS:Eyeballs with the retrobulbar ON attached were ...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067210701700317
更新日期：2007-05-01 00:00:00
abstract：:The primary aim of this study was to summarize and illustrate the main structural cross-sectional optical coherence tomography findings encountered after vitreoretinal surgery for rhegmatogenous retinal detachment. This was a non-systematic review of literature on structural cross-sectional optical coherence tomograph...
journal_title：European journal of ophthalmology
pub_type： 杂志文章,评审
doi：10.1177/1120672120911334
更新日期：2020-07-01 00:00:00
abstract：PURPOSE:The aim of this study is to assess the agreement between manual and automated gonioscopy for iridocorneal angle opening. METHODS:The research is a cross-sectional observational study. Manual and automated gonioscopy were performed to consecutive patients in a glaucoma clinic. Iridocorneal angle opening grading...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/1120672118806436
更新日期：2020-01-01 00:00:00
abstract：PURPOSE:To describe our clinical experience with the efficacy and safety of micropulse transscleral cyclophotocoagulation as a treatment for glaucoma. METHODS:In this retrospective case series, we reviewed the charts of 95 consecutive patients with various glaucoma subtypes who underwent micropulse transscleral cyclop...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/1120672119839303
更新日期：2020-07-01 00:00:00
abstract：PURPOSE:To investigate the low mesopic contrast sensitivity function (LMCSF) of patients implanted with different modern optical bifocal and trifocal designs of multifocal intraocular lenses (mfIOLs). METHODS:This prospective, comparative, nonrandomized consecutive case series included 180 eyes that underwent cataract...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.5301/ejo.5000777
更新日期：2016-11-04 00:00:00
abstract：PURPOSE:To investigate localized retinal dysfunction in hypertensive patients using multifocal electroretinogram (mfERG) and to assess its sensitivity as an early predictor for the development of retinopathy in hypertensive patients. METHODS:Ninety-eight eyes were included in this case-control study. Twenty-eight eyes...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/1120672120934750
更新日期：2020-06-12 00:00:00
abstract：:Purpose. Extraocular muscle (EOM) pulleys are important in eye movement physiology and may play a role in the outcome of strabismus surgery. Few studies have evaluated "normal" position of EOM pulleys. We sought to assess intraoperatively medial rectus (MR) pulley location and variations in a prospective observational...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.5301/ejo.5000187
更新日期：2013-01-21 00:00:00
abstract：PURPOSE:To compare the IOP readings of an ocular blood flow (OBF) tonograph (OBF Labs UK Ltd) with Goldmann applanation tonometry. METHODS:194 patients were studied. In group 1, the software version 8.2 of the OBF tonograph was used in 214 eyes of 107 patients and in group 2, the 11.2 version of the tonograph was used...
journal_title：European journal of ophthalmology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1998-07-01 00:00:00
