Large-area versus small-area application of mitomycin C during trabeculectomy.

Abstract:

PURPOSE:To compare 2 different application methods of mitomycin C (MMC) in patients undergoing trabeculectomy.
 METHODS:This retrospective trial compared outcomes of 191 eyes that underwent trabeculectomy with small-area (96 eyes; 50.3%) and large-area (95 eyes; 49.7%) MMC application. Main outcome measures were changes in intraocular pressure (IOP), required glaucoma medications, the frequency of complications, and postsurgical interventions.
 RESULTS:Within both treatment groups, a highly significant IOP reduction was seen during follow-up (p < 0.0001). Statistical analyses revealed a significant difference in IOP between both groups. Patients treated with a larger size of surface area had a higher IOP reduction within the first postoperative year. Choroidal detachment, shallow anterior chamber, and bleb leak were seen more often in the large-area group with more aggressive MMC use. In contrast, complications associated with bleb failure such as bleb scarring were higher in the small-area group. Success rate was higher in the large-area MMC application group after 12 months.
 CONCLUSIONS:Large-area treatment seems to be a more efficient application method of MMC during trabeculectomy.

journal_name

Eur J Ophthalmol

authors

Matlach J,Panidou E,Grehn F,Klink T

doi

10.5301/ejo.5000287

subject

Has Abstract

pub_date

2013-09-01 00:00:00

pages

670-7

issue

5

eissn

1120-6721

issn

1724-6016

pii

64EE018E-29F5-4C26-A964-5BED9F37012E

journal_volume

23

pub_type

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