Lp(a) is not related to retinopathy in diabetic subjects.

Abstract:

PURPOSE:To examine the association between Lp(a) concentrations and the severity of retinopathy in 22 younger-onset and 48 older-onset diabetic subjects from the Wisconsin Epidemiologic Study of Diabetic Retinopathy (WESDR), a population-based study of diabetic retinopathy. METHODS:We used a subset of the WESDR population with standardized protocols and stereoscopic color fundus photography to determine the severity of diabetic retinopathy in relation to Lp(a) concentrations. Lp(a) concentrations were measured by a monoclonal anti-Lp(a) antibody. RESULTS:Lp(a) levels were not significantly different between younger-onset or older-onset subjects with and without retinopathy. CONCLUSION:Our results do not support a link between higher levels of Lp(a) and severe retinopathy in either younger-onset or older-onset diabetic subjects but this needs confirmation in larger prospective studies.

journal_name

Eur J Ophthalmol

authors

Haffner SM,Klein BE,Moss SE,Klein R

subject

Has Abstract

pub_date

1995-04-01 00:00:00

pages

119-23

issue

2

eissn

1120-6721

issn

1724-6016

journal_volume

5

pub_type

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