Exogenous gonadotropin therapy in World Health Organization groups I and II ovulatory disorders.

Abstract:

OBJECTIVE:To analyze cumulative conception rates and the prognostic factors influencing them during exogenous human menopausal gonadotropin (hMG) therapy for World Health Organization (WHO) group I or II ovulatory disorders. METHODS:A retrospective review was conducted of 468 treatment cycles in 146 women with ovulatory disorders refractory to conventional therapy. Cumulative conception rates were calculated, and the effects of diagnostic group, age, gravidity, and duration of infertility were examined using the Cox proportional hazards model. RESULTS:The cumulative proportion pregnant following six hMG cycles in WHO group I (0.89) was significantly greater than in the hyperandrogenic subgroup of WHO group II (0.30) (95% confidence interval [CI] 0.2-0.7, P = .006) or the luteal phase defect subgroup (0.35) (95% CI 0.07-0.6, P = .02). Conception rates in WHO group I did not differ significantly from those in the normoandrogenic oligo-ovulatory subgroup of WHO group II (0.63) (95% CI 0.3-1.3, P = .6). Conception rates were not influenced by duration of infertility or primary versus secondary infertility. Women 35 years or older had significantly lower conception rates than those aged 27 years or less (P = .04, hazard ratio 0.3, 95% CI 0.1-0.8). CONCLUSIONS:Cumulative conception rates following exogenous gonadotropin therapy for women with refractory ovulatory disorders were both diagnosis- and age-dependent. Treatment with hMG approximated or surpassed normal fertility rates in women with WHO group I and normoandrogenic WHO group II oligo-ovulation, but was significantly less successful at correcting the underlying defect in women with hyperandrogenic anovulation and luteal phase defects.

journal_name

Obstet Gynecol

authors

Fluker MR,Urman B,Mackinnon M,Barrow SR,Pride SM,Yuen BH

subject

Has Abstract

pub_date

1994-02-01 00:00:00

pages

189-96

issue

2

eissn

0029-7844

issn

1873-233X

journal_volume

83

pub_type

杂志文章
  • Prevention of neonatal group B streptococcal disease: intrapartum detection and chemoprophylaxis of heavily colonized parturients.

    abstract::Parturients with heavy vaginal colonization of group B streptococci were selected randomly to receive either penicillin or no antibiotic. A simple and fast latex agglutination test, applied in 8977 consecutive parturients, detected 412 women with heavy colonization with group B streptococcus, 199 of whom were eligible...

    journal_title:Obstetrics and gynecology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Tuppurainen N,Hallman M

    更新日期:1989-04-01 00:00:00

  • A lesson in empathy.

    abstract::The author recounts her recent "high-risk" pregnancy. She relates the feelings experienced by many women in this situation, with the added insights of a certified nurse midwive. The author observes how these insights can be applied by health professionals who deliver care to expectant families. ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: McNatt NL

    更新日期:1980-07-01 00:00:00

  • Sperm penetration assay: useful test in evaluation of male fertility.

    abstract::The recently developed sperm penetration assay (SPA) tests the functional capacity of sperm. It is based upon the ability of in vitro capacitated human spermatozoa to penetrate zona-free hamster eggs in vitro. The SPA was superior to seminal fluid analysis in predicting both fertility and infertility; in the predictio...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Karp LE,Williamson RA,Moore DE,Shy KK,Plymate SR,Smith WD

    更新日期:1981-05-01 00:00:00

  • Dual-Force Vaginoplasty for Treatment of Segmental Vaginal Aplasia.

    abstract:BACKGROUND:Vaginal aplasia occurs in 1 in 5,000-10,000 female live births. In this report, we evaluated a novel dual-force vaginoplasty technique for treatment of 11 patients with segmental vaginal aplasia. TECHNIQUE:The principle of the approach is to thin the atretic part between two counteracting forces. The instru...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/AOG.0000000000001974

    authors: El Saman AM,Farag MA,Shazly SA,Noor M,Ali MK,Othman ER,Khalifa M,Farghly TA,El Saman DA

    更新日期:2017-05-01 00:00:00

  • Hormone replacement therapy after transcervical resection of the endometrium.

    abstract:OBJECTIVE:To determine if women who have undergone transcervical resection of the endometrium can be treated safely with estrogens alone. METHODS:Sixty-two postmenopausal women who had undergone endometrial resection were recruited into a double-blind, randomized study. Twenty-one had menopausal symptoms at the primar...

    journal_title:Obstetrics and gynecology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0029-7844(96)00308-0

    authors: Istre O,Holm-Nielsen P,Bourne T,Forman A

    更新日期:1996-11-01 00:00:00

  • Effect of the menstrual cycle and hormonal contraceptives on human papillomavirus detection in young, unscreened women.

    abstract:OBJECTIVE:To estimate the effect of the menstrual cycle and oral contraceptive pill (OCP) use on the prevalence, incidence, and persistence of human papillomavirus (HPV). METHODS:A longitudinal study was conducted among 2,065 women aged 18-29 years. The women returned a self-collected cervicovaginal sample and filled ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/AOG.0b013e3181e238f0

    authors: Schmeink CE,Massuger LF,Lenselink CH,Quint WG,Melchers WJ,Bekkers RL

    更新日期:2010-07-01 00:00:00

  • External cephalic version for breech presentation with or without spinal analgesia in nulliparous women at term: a randomized controlled trial.

    abstract:OBJECTIVE:To compare the success of external cephalic version using spinal analgesia with no analgesia among nulliparas. METHODS:A prospective randomized controlled trial was performed in a tertiary referral center delivery suite. Nulliparous women at term requesting external cephalic version for breech presentation w...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/01.AOG.0000295605.38175.7b

    authors: Weiniger CF,Ginosar Y,Elchalal U,Sharon E,Nokrian M,Ezra Y

    更新日期:2007-12-01 00:00:00

  • Screening and follow-up of the patient at high risk for breast cancer.

    abstract::Accurately defining a patient's risk of developing breast cancer is a challenging endeavor. Many factors have been implicated in the causation of breast cancer and quantifying them is difficult. Risk stratification is performed using population models, such as the Gail model, as well as the patient's personal and fami...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/01.AOG.0000295638.83285.97

    authors: Willey SC,Cocilovo C

    更新日期:2007-12-01 00:00:00

  • Verrucous carcinoma of the vulva associated with an unusual type 6 human papillomavirus.

    abstract::An unusually rapid growing vulvar verrucous carcinoma found associated with human papillomavirus type 6 is described. Both human papillomavirus structural antigens and deoxyribonucleic acid (DNA) sequences were detected in the tumor biopsy. The human papillomavirus genome was isolated and compared with the genome of h...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/00006250-198603001-00021

    authors: Rando RF,Sedlacek TV,Hunt J,Jenson AB,Kurman RJ,Lancaster WD

    更新日期:1986-03-01 00:00:00

  • Histologic prognosticators in stage I squamous cell carcinoma of the vulva.

    abstract::Sixty-four cases of stage I vulvar squamous cell carcinoma were analyzed histologically to define a patient subset at minimum risk for recurrence or nodal metastases. Three patterns of invasion were predefined: carcinoma in situ with early stromal invasion (33%), pushing (8%), and infiltrative (59%). Infiltrative patt...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Ross MJ,Ehrmann RL

    更新日期:1987-11-01 00:00:00

  • Estradiol absorption from vaginal tablets in postmenopausal women.

    abstract:OBJECTIVE:To evaluate absorption of estradiol (E2) and compare two low doses of 17 beta-E2 (25 microgram and 10 microgram) in postmenopausal women with atrophic vaginitis. METHODS:In a double-masked, randomized, parallel-group study, 58 postmenopausal women were treated with 25 microgram or 10 microgram of 17 beta-E2 ...

    journal_title:Obstetrics and gynecology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0029-7844(01)01385-0

    authors: Notelovitz M,Funk S,Nanavati N,Mazzeo M

    更新日期:2002-04-01 00:00:00

  • Chorioamnionitis and uterine function

    abstract::Objective: To clarify the relationships between intrapartum chorioamnionitis and abnormalities of uterine function, including labor abnormalities, cesarean delivery, and hemorrhage during parturition.Methods: We did a retrospective cohort study on 16,226 deliveries between 1986 and 1996 that were identified from the U...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Mark SP,Croughan-Minihane MS,Kilpatrick SJ

    更新日期:2000-06-01 00:00:00

  • Use of recombinant activated factor VII in primary postpartum hemorrhage: the Northern European registry 2000-2004.

    abstract:OBJECTIVE:To collect data from nine European countries for cases of obstetric hemorrhage between 2000 and 2004 in which recombinant activated factor VII (rFVIIa) was used. METHODS:The cases were identified through national surveys. Standardized case report forms included sociodemographic details, past medical and obst...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/01.AOG.0000288515.48066.99

    authors: Alfirevic Z,Elbourne D,Pavord S,Bolte A,Van Geijn H,Mercier F,Ahonen J,Bremme K,Bødker B,Magnúsdóttir EM,Salvesen K,Prendiville W,Truesdale A,Clemens F,Piercy D,Gyte G

    更新日期:2007-12-01 00:00:00

  • Umbilical venous erythropoietin and umbilical arterial pH in relation to morphologic placental abnormalities.

    abstract:OBJECTIVE:To investigate the relation between the biochemical markers of umbilical venous erythropoietin and umbilical arterial pH and morphologic placental abnormalities in fetal hypoxia. METHODS:Placentas from 300 high-risk newborn infants (gestational age 24-42 weeks) were examined macroscopically and microscopical...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Maier RF,Günther A,Vogel M,Dudenhausen JW,Obladen M

    更新日期:1994-07-01 00:00:00

  • Microangiopathic Hemolytic Anemia Due to Malignancy in Pregnancy.

    abstract:BACKGROUND:Microangiopathic disorders during pregnancy remain a diagnostic challenge because these conditions often imitate more common obstetric diseases. CASE:A 31-year-old multigravid woman delivered at term with a postpartum course complicated by laboratory indices consistent with hemolysis, elevated liver enzymes...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/AOG.0000000000001675

    authors: Happe SK,Zofkie AC,Nelson DB

    更新日期:2016-12-01 00:00:00

  • Can prenatal vitamin K1 (phylloquinone) supplementation replace prophylaxis at birth?

    abstract:OBJECTIVE:To assess the effect of prenatal vitamin K1 on the coagulation status of newborns. METHODS:We measured noncarboxylated prothrombin and performed the Normotest in two groups of 5-day-old infants whose mothers were given oral vitamin K1, 10 mg/day for 2 weeks at least 10 days before delivery, or were untreated...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Anai T,Hirota Y,Yoshimatsu J,Oga M,Miyakawa I

    更新日期:1993-02-01 00:00:00

  • Preoperative core needle biopsy as an independent risk factor for wound infection after breast surgery.

    abstract:OBJECTIVE:Diverging findings concerning the rate of postoperative wound infections in patients undergoing breast surgery have been reported, and little is known regarding the possible risk factors for these infections and their relative importance. We assessed risk factors for wound infection, placing particular emphas...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/s0029-7844(03)00044-9

    authors: Witt A,Yavuz D,Walchetseder C,Strohmer H,Kubista E

    更新日期:2003-04-01 00:00:00

  • Abortion and mental health: findings from The National Comorbidity Survey-Replication.

    abstract:OBJECTIVE:To examine whether a first abortion increases risk of mental health disorders compared with a first childbirth with and without considering prepregnancy mental health and adverse exposures, childhood economic status, miscarriage history, age at first abortion or childbirth, and race or ethnicity. METHODS:A c...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/AOG.0000000000000092

    authors: Steinberg JR,McCulloch CE,Adler NE

    更新日期:2014-02-01 00:00:00

  • Evaluation of Early Pregnancy Concerns in an Early Pregnancy Unit Compared With an Emergency Department.

    abstract:OBJECTIVE:To assess total time for evaluation of women with first-trimester pregnancy concerns in an early pregnancy unit compared with an emergency department (ED) within a single safety net hospital system. METHODS:We performed a retrospective cohort study at Denver Health Medical Center from May 1, 2017, to April 3...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/AOG.0000000000004080

    authors: VanArendonk SH,Rockhill K,Stickrath EH,Alston MJ

    更新日期:2020-11-01 00:00:00

  • Cordocentesis for the diagnosis and treatment of human fetal parvovirus infection.

    abstract::Human parvovirus B-19 infection was diagnosed by DNA hybridization in blood obtained by cordocentesis from two hydropic fetuses at 22 and 26 weeks' gestation; B-19-specific immunoglobulin M (IgM) in fetal blood was negative in both cases. Hematologic studies demonstrated severe anemia, which was treated by intravascul...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Peters MT,Nicolaides KH

    更新日期:1990-03-01 00:00:00

  • Early fetal movement: a real-time ultrasound study.

    abstract::A single-transducer mechanical sector scanner was used to examine the first-trimester fetus. Fifty-six examinations of 31 patients demonstrated an orderly developmental progression of fetal activity beginning with beating of the fetal heart (7 weeks), progressing to fetal trunk movement (8 weeks), and culminating in i...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Shawker TH,Schuette WH,Whitehouse W,Rifka SM

    更新日期:1980-02-01 00:00:00

  • Pregnancy outcome following exposure to angiotensin-converting enzyme inhibitors.

    abstract:OBJECTIVE:Case reports of suspected adverse pregnancy outcomes associated with prenatal exposure to angiotensin-converting enzyme inhibitors, particularly oligohydramnios, prolonged neonatal anuria, and defects of ossification of the skull dome, prompted us to examine pregnancy outcome in a large cohort of pregnant wom...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Piper JM,Ray WA,Rosa FW

    更新日期:1992-09-01 00:00:00

  • Mechanisms of action of regulatory T cells specific for paternal antigens during pregnancy.

    abstract:OBJECTIVE:To investigate whether pregnancy-induced regulatory T cells are generated specifically for paternal antigens or expanded by hormonal changes and to study regulatory T cell-related mechanisms during pregnancy. METHODS:We used murine models of normal, abortion-prone, and pseudopregnancy to characterize regulat...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/01.AOG.0000284625.10175.31

    authors: Schumacher A,Wafula PO,Bertoja AZ,Sollwedel A,Thuere C,Wollenberg I,Yagita H,Volk HD,Zenclussen AC

    更新日期:2007-11-01 00:00:00

  • Early oral feeding after cesarean delivery.

    abstract:OBJECTIVE:To assess the gastrointestinal function and patient acceptability of early initiation of oral feeding after cesarean delivery. METHODS:Two hundred twenty-one healthy women delivered by cesarean were assigned in an alternating manner to receive either a high-protein, low-residue pudding initiated within 6 hou...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/0029-7844(96)00049-x

    authors: Soriano D,Dulitzki M,Keidar N,Barkai G,Mashiach S,Seidman DS

    更新日期:1996-06-01 00:00:00

  • Committee Opinion No. 680 Summary: The Use and Development of Checklists in Obstetrics and Gynecology.

    abstract::Checklists are used in medical and nonmedical settings as cognitive aids to ensure that users complete all the items associated with a particular task. They are ideal for tasks with many steps, for tasks performed under stressful circumstances, or for reminding people to perform tasks that they are not routinely accus...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/AOG.0000000000001766

    authors:

    更新日期:2016-11-01 00:00:00

  • Prophylactic and risk-reducing bilateral salpingo-oophorectomy: recommendations based on risk of ovarian cancer.

    abstract::Women who do not have a documented germline mutation or who do not have a strong family history suspicious for a germline mutation are considered to be at average risk of ovarian cancer. Women who have confirmed deleterious BRCA1 and BRCA2 germline mutations are high risk of ovarian cancer. In addition, women who have...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/AOG.0b013e3181ec5fc1

    authors: Berek JS,Chalas E,Edelson M,Moore DH,Burke WM,Cliby WA,Berchuck A,Society of Gynecologic Oncologists Clinical Practice Committee.

    更新日期:2010-09-01 00:00:00

  • Silicone band sterilization with radiographic and laparoscopic evaluation.

    abstract::Laparoscopic tubal sterilization, using a Silastic band to occlude the tubal lumen, was performed on 224 patients. The incidence of complications was low and only 2 pregnancies occurred. Further evaluation by hysterosalpingography on 97 patients revealed 2 distinct images. The site of tubal occlusion was seen on lapar...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Beck P,Gal D,Tancer ML

    更新日期:1979-06-01 00:00:00

  • Vascular injury during tension-free vaginal tape procedure for stress urinary incontinence.

    abstract:BACKGROUND:Tension-free vaginal tape procedure is a popular surgical treatment of genuine stress urinary incontinence. CASES:Two cases of retropubic hematoma after tension-free vaginal tape procedure are reported. One woman with an 8 x 10 cm hematoma localized to the retropubic space required transfusion of two units ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/s0029-7844(01)01560-5

    authors: Walters MD,Tulikangas PK,LaSala C,Muir TW

    更新日期:2001-11-01 00:00:00

  • Risk factors for endometrial hyperplasia and cancer among women with abnormal bleeding.

    abstract:OBJECTIVE:To identify independent risk factors for endometrial neoplasia in women with abnormal perimenopausal or postmenopausal bleeding and to use those factors to develop and test a predictive model. METHODS:We conducted a case-control study of women with abnormal perimenopausal or postmenopausal bleeding who had e...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/s0029-7844(98)00469-4

    authors: Weber AM,Belinson JL,Piedmonte MR

    更新日期:1999-04-01 00:00:00

  • Comparing perinatal mortality.

    abstract::Comparisons of perinatal outcome data among regions or hospitals can be misleading if the risk status of the population served is not considered. Data are presented from two large perinatal centers (Medical Center Hospital in San Antonio, Texas, and University of Iowa Hospitals in Iowa City, Iowa), which report substa...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Hein HA,Lathrop SS,Papke KR

    更新日期:1985-09-01 00:00:00