Can prenatal vitamin K1 (phylloquinone) supplementation replace prophylaxis at birth?

Abstract:

OBJECTIVE:To assess the effect of prenatal vitamin K1 on the coagulation status of newborns. METHODS:We measured noncarboxylated prothrombin and performed the Normotest in two groups of 5-day-old infants whose mothers were given oral vitamin K1, 10 mg/day for 2 weeks at least 10 days before delivery, or were untreated. RESULTS:Noncarboxylated prothrombin was found in one of 74 treated women and 13 of 186 controls, a nonsignificant difference. The mean (+/- standard deviation) Normotest value was 59.6 +/- 10.1% (range 38.9-84.4) for the treated group and 53.4 +/- 9.9% (range 16.3-89.9) for the controls, a statistically significant difference (P < .001). CONCLUSION:Based on the Normotest results, we suggest that vitamin K crosses the placenta and persists to activate the vitamin K-dependent coagulant factors until at least the fifth day of life. Thus, prenatal vitamin K1 administration may replace prophylaxis at birth.

journal_name

Obstet Gynecol

authors

Anai T,Hirota Y,Yoshimatsu J,Oga M,Miyakawa I

subject

Has Abstract

pub_date

1993-02-01 00:00:00

pages

251-4

issue

2

eissn

0029-7844

issn

1873-233X

journal_volume

81

pub_type

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