A story of two miracles: the impact of the discovery of insulin on pregnancy in women with diabetes mellitus.

Abstract:

:Before the discovery of insulin in 1921, pregnancies in women with diabetes mellitus were a rarity because most reproductive-age patients died soon after diagnosis of this illness. In the limited number of pregnancies reported in the pre-insulin era, both perinatal and maternal mortality were approximately 50%, with stillbirths being the primary cause of perinatal deaths. Insulin treatment restored the fertility of women with diabetes and was associated with a marked reduction in maternal mortality. Women with more severe disease had the opportunity to become pregnant; however, their pregnancies frequently resulted in neonatal death due to prematurity. Therefore, perinatal mortality was not substantially reduced.

journal_name

Obstet Gynecol

authors

Gabbe SG

subject

Has Abstract

pub_date

1992-02-01 00:00:00

pages

295-9

issue

2

eissn

0029-7844

issn

1873-233X

journal_volume

79

pub_type

历史文章,杂志文章
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