Ornithine decarboxylase and S-adenosyl methionine decarboxylase in skin fibroblasts of normal and cystic fibrosis patients.

abstract：:All enzymes of the urea cycle are demonstrable in circulating leukocytes. They show the same relative activities as those in liver except for argininosuccinate synthetase + lyase (combined) which seems to be disproportionately active. To see whether leukocytes reflect liver activity, blood from patients with three hep...

journal_title：Pediatric research

authors： Wolfe DM,Gatfield PD

更新日期：1975-06-01 00:00:00

abstract：BACKGROUND:The basal ganglia are vulnerable to injury during cardiac arrest. Movement disorders are a common morbidity in survivors. Yet, neuronal motor network changes post-arrest remain poorly understood. METHODS:We compared function of the motor network in adult rats that, during postnatal week 3, underwent 9.5 min...

journal_title：Pediatric research

authors： Aravamuthan BR,Shoykhet M

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Angiotensin (ANG) II is involved in experimental hyperoxia-induced lung fibrosis. Angiotensin-converting enzyme-2 (ACE-2) degrades ANG II and is thus protective, but is downregulated in adult human and experimental lung fibrosis. Hyperoxia is a known cause of chronic fibrotic lung disease in neonates, but th...

journal_title：Pediatric research

authors： Oarhe CI,Dang V,Dang M,Nguyen H,Gopallawa I,Gewolb IH,Uhal BD

更新日期：2015-05-01 00:00:00

abstract：:We studied the mechanisms by which C16:0 lysophosphatidylcholine (LPC) and albumin inhibit the surface activity of calf lung surfactant extract (CLSE) by using a pulsating bubble apparatus with a specialized hypophase exchange system, plus adsorption and Wilhelmy balance measurements. In the absence of inhibitors, CLS...

journal_title：Pediatric research

authors： Holm BA,Wang Z,Notter RH

更新日期：1999-07-01 00:00:00

abstract：:To date, many mutations, including intronic nucleotide changes, in the SLC12A3 gene encoding the thiazide-sensitive sodium-chloride cotransporter (NCCT) have been reported in Gitelman's syndrome (GS) patients. However, it has not been clarified whether intronic nucleotide changes affect mRNA content. Since mRNA analys...

journal_title：Pediatric research

authors： Kaito H,Nozu K,Fu XJ,Kamioka I,Fujita T,Kanda K,Krol RP,Suminaga R,Ishida A,Iijima K,Matsuo M

更新日期：2007-04-01 00:00:00

abstract：:The widespread use of phototherapy for neonatal hyperbilirubinemia has caused some concern since substances other than bilirubin may be photoactivated. The toxic properties of these photoactivated substances might prove to be more harmful to the neonatal infant than bilirubin. The purpose of the present study was to i...

journal_title：Pediatric research

authors： Speck WT,Chen CC,Rosenkranz HS

更新日期：1975-03-01 00:00:00

abstract：:Matrix metalloproteinases (MMP) are likely effectors of normal lung development, especially branching morphogenesis, angiogenesis, and extracellular matrix degradation. Because hyperoxia exposure (>95% O(2)) from d 4 to 14 in newborn rat pups leads to arrest of alveolarization and mimics newborn chronic lung disease, ...

journal_title：Pediatric research

authors： Hosford GE,Fang X,Olson DM

更新日期：2004-07-01 00:00:00

abstract：:We evaluated bone mineralization by single photon absorptiometry at 2 y in a cohort of preterm infants studied since birth. Infants were fed human milk fortified with Ca [to achieve 80 mg/dL (19.96 mmol/L)] and P [40 mg/dL (12.91 mmol/L)] from wk 2 through 8 after birth. After hospital discharge, infants were divided ...

journal_title：Pediatric research

authors： Schanler RJ,Burns PA,Abrams SA,Garza C

更新日期：1992-06-01 00:00:00

abstract：BACKGROUND:Heterozygous ATP-binding-cassette subfamily A member 3 (ABCA3) mutations are associated with neonatal respiratory complications. In an adult murine model, we investigated whether Abca3 haploinsufficiency is a predisposing factor for lung injury induced by hyperoxia or mechanical ventilation. METHODS:Abca3 h...

journal_title：Pediatric research

authors： Herber-Jonat S,Mittal R,Huppmann M,Hammel M,Liebisch G,Yildirim AÖ,Eickelberg O,Schmitz G,Hrabé de Angelis M,Flemmer AW,Holzinger A

更新日期：2013-10-01 00:00:00

abstract：:Primary immunodeficiencies (PIDs) have traditionally been defined according to their immunologic phenotype. Far from being concluded, the search for human genes that, when mutated, cause PID is actively being pursued. During the last year, four novel genetic defects that cause severe combined immunodeficiency and seve...

journal_title：Pediatric research

authors： Pessach I,Walter J,Notarangelo LD

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:This study aimed to assess cortical gray matter growth and maturation in neonates with congenital heart disease (CHD). METHODS:Thirty-one (near) term neonates with severe CHD (8 univentricular heart malformation (UVH), 21 d-transposition of great arteries (d-TGA) and 2 aortic coarctation) underwent cerebral...

journal_title：Pediatric research

authors： Claessens NH,Moeskops P,Buchmann A,Latal B,Knirsch W,Scheer I,Išgum I,de Vries LS,Benders MJ,von Rhein M

更新日期：2016-11-01 00:00:00

abstract：:In neuronal cultures from the forebrain of 14-d-old rat embryos, transient hypoxia (95% N2/5% CO2, 37 degrees C) for 6 h has been shown to trigger delayed apoptotic death through sequential changes in protein synthesis, whereas preconditioning by a brief episode of hypoxia can rescue neurons. Because hypothermia has b...

journal_title：Pediatric research

authors： Bossenmeyer-Pourié C,Koziel V,Daval JL

更新日期：2000-03-01 00:00:00

abstract：:Liposomes can be used for the delivery of drugs in cancer chemotherapy. After i.v. injection liposomes are to a large extent taken up by the mononuclear phagocytic system (MPS). When treating diseases in the MPS, such as the histiocytic syndromes, this property is of potential value for drug targeting and may lead to ...

journal_title：Pediatric research

authors： Liliemark E,Liliemark J,Kållberg N,Björkholm M,Sjöström B,Peterson C

更新日期：1995-07-01 00:00:00

abstract：:Clinical studies have suggested that the early stages of bilirubin encephalopathy are reversible. These phenomena are investigated at the cellular level using the neuroblastoma cell line N-115 as a model system. To determine whether the cell line N-115 can recover from bilirubin toxicity, and whether the cellular func...

journal_title：Pediatric research

authors： Amit Y,Poznansky MJ,Schiff D

更新日期：1989-04-01 00:00:00

abstract：:The effect of alpha-adrenergic blockade by phentolamine on the pulmonary vascular response to dopamine was studied in chronically prepared newborn lambs. Dopamine was administered at doses of 2.7 micrograms . kg-1 . min-1, 27 micrograms . kg-1 . min-1 and 270 micrograms . kg-1 . min-1 with and without alpha-adrenergic...

journal_title：Pediatric research

authors： Williams BJ,Drummond WH

更新日期：1983-06-01 00:00:00

abstract：:Evaluation of nonlinear heart rate (HR) dynamics has received considerable attention in the pediatric literature because such analyses not only provide insight into underlying control mechanisms, but may also help to differentiate between normal and abnormal infants. The purpose of this study was to determine, in eigh...

journal_title：Pediatric research

authors： Mooney DM,Groome LJ,Holland SB,Smith YD

更新日期：1998-07-01 00:00:00

abstract：:Sequential magnitude and the rate of change in tracheal mechanics after application of intermittent positive pressure (IPP), and the time constant, tau, of this deformation were determined in fetal (21 and 27 days gestation), neonatal (term, 31 days gestation) and adult rabbits. In vitro tracheal mechanics were determ...

journal_title：Pediatric research

authors： Bhutani VK,Shaffer TH

更新日期：1982-10-01 00:00:00

abstract：:Hydrocephalus may result in loss of tissue associated with neuronal degeneration, axonal damage, and reactive gliosis. The soluble form of the anti-apoptotic regulator Fas (sFas) and the pro-apoptotic factors soluble FasL (sFasL) and activated caspase 3 were studied in the cerebrospinal fluid of infants with hydroceph...

journal_title：Pediatric research

authors： Felderhoff-Mueser U,Buhrer C,Groneck P,Obladen M,Bartmann P,Heep A

更新日期：2003-11-01 00:00:00

abstract：:Sex steroids accelerate bone maturation, but it is believed that estrogen action is needed for terminal epiphyseal fusion. In this study, we investigated the effects of a new estrogen-blocking agent, Faslodex (ICI 182,780), on estrogen-accelerated skeletal maturation in immature mice. On day-of-life 2 through 8, mice ...

journal_title：Pediatric research

authors： Gunther DF,Calikoglu AS,Underwood LE

更新日期：1999-09-01 00:00:00

abstract：:The placenta is essential to nutrition before birth. Recent work has shown that a range of clearly defined alterations can be found in the placentas of infants with intrauterine growth restriction (IUGR). In the mouse, a placental specific knockout of a single imprinted gene, encoding IGF-2, results in one pattern of ...

journal_title：Pediatric research

authors： Sibley CP,Turner MA,Cetin I,Ayuk P,Boyd CA,D'Souza SW,Glazier JD,Greenwood SL,Jansson T,Powell T

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:For the second aim of the Kellogg Foundation grant, this double-blind RCT investigated the impact of plasma vitamin D metabolite 25-hydroxyvitamin D (25(OH)D) on plasma immune-mediators during pregnancy. We hypothesized that higher 25(OH)D concentrations would associate with reduced pro-inflammatory and incr...

journal_title：Pediatric research

authors： Khatiwada A,Wolf BJ,Mulligan JK,Shary JR,Hewison M,Baatz JE,Newton DA,Hawrylowicz C,Hollis BW,Wagner CL

更新日期：2020-04-20 00:00:00

abstract：:It is customary to estimate the uteroplacental function in singletons by defining appropriateness of birth weight by gestational age. Such a measure, however, is not available for the entire multiple pregnancy set. We evaluate a new index, total triplet birth weight, expressed as multiples of the median (MOM) birth we...

journal_title：Pediatric research

authors： Blickstein I,Salihu HM,Keith LG,Alexander GR

更新日期：2006-04-01 00:00:00

abstract：:We assessed the kinetics of hyperoxia-induced prostaglandin E2 (PGE2) production by cultured rabbit tracheal epithelial (TE) cells with different inherent capacities to generate PGE2 and the role of endogenous PGE2 production in protecting these cells from hyperoxic injury. Rabbit TE cells grown to confluence with or ...

journal_title：Pediatric research

authors： Dennery PA,Walenga RW,Kramer CM,Alpert SE

更新日期：1992-07-01 00:00:00

abstract：:The intranasal live attenuated influenza vaccine (LAIV), FluMist, has been widely appreciated by pediatricians, parents, and children alike for its ease of administration. However, concerns regarding lack of effectiveness in recent influenza seasons led to the CDC Advisory Committee on Immunization Practices (ACIP) re...

journal_title：Pediatric research

authors： Gill MA,Schlaudecker EP

更新日期：2018-01-01 00:00:00

abstract：:We recently demonstrated that recombinant hGH exacerbates renal functional and structural injury in chronic puromycin aminonucleoside (PAN) nephropathy, an experimental model of glomerular disease. Therefore, we examined whether recombinant human (rh) IGF-I is a safer alternative for the treatment of growth failure in...

journal_title：Pediatric research

authors： Trachtman H,Maesaka J,Futterweit S,Ma C,Valderrama E,Chan JC,Chan W

更新日期：1996-01-01 00:00:00

abstract：:The copper concentrations in organs of developing Long-Evans Cinnamon (LEC) rats (2 d to 13 mo) were measured to elucidate the pathogenesis of their hereditary hepatitis. Hepatic copper contents of LEC rats were significantly higher than those of control rats (26 to 92 times higher). The subcellular distribution of he...

journal_title：Pediatric research

authors： Okayasu T,Tochimaru H,Hyuga T,Takahashi T,Takekoshi Y,Li Y,Togashi Y,Takeichi N,Kasai N,Arashima S

更新日期：1992-03-01 00:00:00

abstract：BACKGROUND:A growing body of evidence defines inflammation as a hallmark feature of disease pathogenesis of Duchenne muscular dystrophy. To tailor potential immune modulatory interventions, a better understanding of immune dysregulation in Duchenne muscular dystrophy is needed. We now asked whether dystrophin deficienc...

journal_title：Pediatric research

authors： Kranig SA,Tschada R,Braun M,Patry C,Pöschl J,Frommhold D,Hudalla H

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Using a large population-based sample, this study aims to verify whether televiewing at 29 mo, a common early childhood pastime, is prospectively associated with school readiness at 65 mo. METHODS:Participants are a prospective longitudinal cohort of 991 girls and 1,006 boys from the Quebec Longitudinal Stu...

journal_title：Pediatric research

authors： Pagani LS,Fitzpatrick C,Barnett TA

更新日期：2013-09-01 00:00:00

abstract：:Neonatal animals of several species are more tolerant of hyperoxic exposure than are adults, but the mechanisms of increased neonatal tolerance are unknown, as are the cell types, if any, that contribute to oxygen resistance. We studied the effect of in vivo exposure to 85% oxygen for 72 h on the activities of the ant...

journal_title：Pediatric research

authors： Keeney SE,Cress SE,Brown SE,Bidani A

更新日期：1992-05-01 00:00:00

abstract：:Adenylate cyclase activity was measured in membrane preparations of cultured fibroblasts from controls and patients with cystic fibrosis. Enzyme activity increased as the transition from exponential growth to confluence occurred; sodium fluoride-stimulated activity more markedly displayed this relationship than basal ...

journal_title：Pediatric research

authors： Wright RK,Buehler BA,Schott SN,Rennert OM

更新日期：1978-08-01 00:00:00