Thioridazine-hydrochloride-associated agranulocytosis.

Abstract:

:A patient with thioridazine-hydrochloride-associated agranulocytosis is described and eight previously reported cases are reviewed. This complication is most likely due to a direct toxic effect on the bone marrow. As in our case, markers for an immunologically mediated mechanism have not been found. Thioridazine-hydrochloride-associated agranulocytosis usually occurs between the fifth and 11th week of therapy and is not related to the total dose of drug received. Three of the nine patients with thioridazine-hydrochloride-associated agranulocytosis have died from infectious complications. Thus, careful monitoring for infection and prompt therapy are indicated.

journal_name

South Med J

journal_title

Southern medical journal

authors

Ferguson RL,Hodges GR,Bogner PJ

doi

10.1097/00007611-197701000-00051

subject

Has Abstract

pub_date

1977-01-01 00:00:00

pages

110-1

issue

1

eissn

0038-4348

issn

1541-8243

journal_volume

70

pub_type

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