Abstract:
OBJECTIVES:Hematological malignancies of the breast share a presentation similar to primary breast carcinomas but differ substantially in therapeutic approach and clinical outcomes. In this study, we investigate the frequency of hematological malignancies, their relative primary and secondary occurrences, and further characterize the distinct histopathologies of these malignancies with a special focus on lymphomas. To our knowledge this is one of the largest and most comprehensive studies of breast hematologic malignancies. METHODS:We conducted a retrospective review of our institution's pathology database for hematologic neoplasms diagnosed in breast tissue during a period of 22 years (1992-2014). Clinical characteristics, patient history, histologic subtype, and patient outcomes were analyzed. RESULTS:We identified 52 cases; 46 lymphomas, 4 plasmacytomas, and 2 myeloid sarcomas. The lymphoma cases were 15 diffuse large B-cell lymphomas (DLBCLs), 14 follicular lymphomas (FLs), 8 marginal zone lymphomas (MZLs), 2 anaplastic large T-cell lymphomas, 2 peripheral T-cell lymphomas-not otherwise specified, 1 each of small lymphocytic lymphoma, Burkitt lymphoma, mantle cell lymphoma, B-cell lymphoblastic lymphoma, and T-cell lymphoblastic lymphoma. In total, 30 cases were primary and 22 cases were secondary to the breast. Primary lymphomas accounted for 60% of lymphomas. Most FLs and almost all MZLs were primary. CONCLUSIONS:Primary hematological malignancies of the breast are more common than secondary: 58 % versus 42%. This finding is more evident in lymphomas: 63% versus 37%. The most common hematological malignancy in our study was DLBCL, followed by FL and MZL. Most FLs and almost all MZLs were primary. At the same time, the percentage of primary DLBCLs in our study is lower than the percentage reported in previous studies. We suggest that this could be the result of transformation from low-grade lymphomas. Although rare, hematological malignancies of the breast warrant a higher level of clinical suspicion as they present similarly to breast carcinomas but require a substantially different therapeutic approach.
journal_name
South Med Jjournal_title
Southern medical journalauthors
Alsadi A,Lin D,Alnajar H,Brickman A,Martyn C,Gattuso Pdoi
10.14423/SMJ.0000000000000710subject
Has Abstractpub_date
2017-10-01 00:00:00pages
614-620issue
10eissn
0038-4348issn
1541-8243pii
SMJ50438journal_volume
110pub_type
杂志文章abstract:OBJECTIVES:Studies have shown that the overutilization of laboratory tests ("labs") for hospitalized patients is common and can cause adverse health outcomes. Our objective was to compare the ordering tendencies for routine complete blood counts (CBC) and chemistry panels by internal medicine residents and hospitalists...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000000592
更新日期:2017-01-01 00:00:00
abstract::Our patient's symptoms of adrenal insufficiency were the first evidence of recurrence of the primary tumor. The diagnosis of hypoadrenalism was established by the standard ACTH stimulation test. The elevated ACTH level provided corroborating evidence that this was primary adrenal insufficiency rather than secondary to...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198412000-00031
更新日期:1984-12-01 00:00:00
abstract:OBJECTIVE:Intraventricular hemorrhage (IVH) represents a clinicopathologic entity with a dismal prognosis. The associated mortality rate has been reported as high as 80%; the morbidity is also quite high. The use of various fibrinolytic agents (streptokinase, urokinase, and recombinant tissue-type plasminogen activator...
journal_title:Southern medical journal
pub_type: 临床试验,杂志文章
doi:10.1097/01.smj.0000170732.24324.ea
更新日期:2005-08-01 00:00:00
abstract::This paper reports results of a project designed to examine factors related to compliance with referral for follow-up and treatment of cervical dysplasia. Women studied had cervical dysplasia diagnosed by Pap smear between May 1989 and April 1990. These women had regular follow-up at the gynecology clinic of the Reyno...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199201000-00003
更新日期:1992-01-01 00:00:00
abstract::A 74-year-old man was admitted with rhabdomyolysis after undergoing initial treatment for gastrointestinal cancer with irinotecan. The syndrome partially resolved after the discontinuation of all of his usual medications, including his chronic selective serotonin reuptake inhibitor (SSRI). The rhabdomyolysis was exace...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/01.SMJ.0000084311.35864.D6
更新日期:2003-10-01 00:00:00
abstract::Coagulopathy due to tuberculosis is rare. We believe ours is only the second reported case of cavitary tuberculosis associated with disseminated intravascular coagulation. Our review of all 13 cases to date shows that the patients are generally black, middle-aged, male, alcoholic, and febrile. The tuberculosis is gene...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-199001000-00019
更新日期:1990-01-01 00:00:00
abstract::To date, screening has largely failed to fulfill the hope that early detection would lead to more effective early treatment and to improved health status in the population served. The future role of screening can be much more positive but only if (1) screening is directed only at diseases and conditions for which earl...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:1977-10-01 00:00:00
abstract::An increased risk of skin and lymphoreticular malignancies is well documented in renal transplant patients receiving long-term immunosuppressive therapy, but squamous cell carcinoma of the esophagus is rare. We have reported the first case in the English literature in which there is a strong association between long-t...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198712000-00025
更新日期:1987-12-01 00:00:00
abstract::This review assessed the overall effectiveness of repeated treatments with botulinum toxin type A (BoNTA) across different conditions, as documented in the published literature. Forty-four original research articles reporting on 16 different conditions were identified that included data on the duration or efficacy of ...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/01.smj.0000220888.88722.ab
更新日期:2006-08-01 00:00:00
abstract::We have described a patient who had lung carcinoma, syndrome of inappropriate antidiuretic hormone, and central pontine myelinolysis (CPM). Although this association is well-known, it appears to be the first report having radiographic documentation of both the intracranial and intrathoracic abnormalities. When searchi...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199204000-00019
更新日期:1992-04-01 00:00:00
abstract:OBJECTIVES:Total annual costs for syncope-related hospitalizations were $2.4 billion in 2000. The aim of this study was to examine the type and number of tests ordered for patients admitted with syncope and whether these tests helped establish the cause. METHODS:We studied the records of 1038 patients coded as "syncop...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000000184
更新日期:2014-11-01 00:00:00
abstract::A poorly understood significant drug-drug interaction compounded by ineffective communication among providers at times of care transition most likely contributed to multiple thromboembolic events in an 81-year-old patient. Increased awareness of drug interactions with direct oral anticoagulants (DOACs), as well as imp...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000000926
更新日期:2019-02-01 00:00:00
abstract::The association between acute coronary events and acute allergic reactions has been recognized for several years. The first reported case occurred in 1950, during an allergic reaction to penicillin. In 1991, Kounis and Zavras described the syndrome of allergic angina and allergic myocardial infarction, currently known...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e3181f8c56f
更新日期:2010-11-01 00:00:00
abstract:OBJECTIVE:This study aimed to identify differences in perceptions between healthcare and non-healthcare personnel when it comes to wearing scrubs in non-healthcare settings. METHODS:An anonymous survey with 11 closed-ended questions sent via e-mail to healthcare students and employees at The University of Texas Health...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000000861
更新日期:2018-09-01 00:00:00
abstract::The incidence of fatal and nonfatal pulmonary embolism (PE) was evaluated in a series of 578 patients, to quantify the suspected higher risk in cancer patients of death from massive PE when compared with patients not having cancer. PE occurred in 13% and was fatal in 8% of noncancer patients. It occurred in 17% and wa...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198007000-00005
更新日期:1980-07-01 00:00:00
abstract::A technic incorporating the simultaneous elevation of multiple adjacent thoracoabdominal pedicale flaps, based in opposite directions, has been successfully used on four patients with extensive degloving injuries of the hand. In all cases, the hand was later divided into individual digits. A five-year follow-up of thr...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197803000-00024
更新日期:1978-03-01 00:00:00
abstract::The value of splenoportography in evaluating patients with portal hypertension was assessed. The technic was found to be useful in estimating portal-venous pressure, ruling out portal vein thrombosis, evaluating the superior mesenteric and portal veins as to their suitability for shunt procedures, and defining anatomy...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197710000-00017
更新日期:1977-10-01 00:00:00
abstract::Two premature infants were infected with HIV via blood transfusions during the neonatal period. Although neither patient had serum antibody to HIV owing to severe hypogammaglobulinemia, HIV infection was confirmed by finding HIV antigen in the sera of both patients. These cases show that HIV infection can produce seve...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198904000-00005
更新日期:1989-04-01 00:00:00
abstract::A patient with a large paraesophageal hernia had a Nissen fundoplication via laparoscopy. He returned a year later with the transverse colon herniated into the chest. At operation, the hernia ostium was found to be the aortic hiatus. We believe that the original ostium was missed because of the limited exposure of the...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199703000-00016
更新日期:1997-03-01 00:00:00
abstract:BACKGROUND:To design and evaluate interventions for reducing the impact of stroke in Georgia, we assessed knowledge of signs, risk factors, and burden of stroke. METHODS:Adults in Georgia were studied with a random digit dial telephone survey. RESULTS:Answering an unaided question, 39% of 602 respondents named > or =...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:2001-06-01 00:00:00
abstract::Patients with sickle cell disease are predisposed to infection caused by Streptococcus pneumoniae. However, there has been only one published case of bacteremic pneumococcal meningitis in an adult with sickle cell anemia. We report here the cases of six adults with sickle cell disease, pneumococcal sepsis, and meningi...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199009000-00005
更新日期:1990-09-01 00:00:00
abstract::A patient ingested a massive amount of an oral theophylline preparation and recovered. The paucity of central nervous system manifestations may have been related to the presence of fulminant diarrhea with expulsion of the tablets per rectum. ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197808000-00027
更新日期:1978-08-01 00:00:00
abstract::Between September 1983 and March 1989, 36 loop ileostomies were performed on 34 patients (16 male and 18 female, mean age 36 years, range 11 to 68). Thirty-two patients had ileoanal pouch procedures (30 for ulcerative colitis and two for familial polyposis). One patient had a low anterior resection and another had a c...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199403000-00014
更新日期:1994-03-01 00:00:00
abstract::This review article provides insight into the evolution of professional healthcare chaplaincy. It identifies key historical developments identifying the training, qualifications, and competencies of chaplains. Consideration is given to both the unique character of the pastoral role in healthcare as well as the contrib...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/01.smj.0000220893.37354.1e
更新日期:2006-06-01 00:00:00
abstract::The number of breast cancer survivors has increased and this increase is expected to continue, likely as a result of population and age growth, the implementation of earlier detection strategies, and the development of more effective therapies. Breast cancer treatment requires a multidisciplinary approach with surgery...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.14423/SMJ.0000000000000701
更新日期:2017-10-01 00:00:00
abstract::Noninvasive positive pressure ventilation (NPPV) has been used in treatment of a variety of clinical conditions, including acute respiratory failure (ARF) due to status asthmaticus. We present the case of a patient admitted with acute exacerbation of asthma who had ARF and required mechanical ventilation. After extuba...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199701000-00017
更新日期:1997-01-01 00:00:00
abstract::Retinal detachment complicating proliferative diabetic retinopathy is being recognized with increasing frequency. Although one type of detachment is tractional and requires vitrectomy for hopeful repair, the other variety of detachment is rhegmatogenous. The rhegmatogenous form of retinal detachment does not generally...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-197810000-00007
更新日期:1978-10-01 00:00:00
abstract::Documented fetal inactivity is strongly suggestive of fetal jeopardy, but the significance of excessive activity over a prolonged period has not been reported. Using data gathered from fetal movement charts recorded by 931 patients, fetal hyperactivity was defined statistically as 40 or more movements perceived per ho...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198302000-00005
更新日期:1983-02-01 00:00:00
abstract:OBJECTIVES:The objective of this study was to assess the cardiovascular health status of baby boomers with diabetes mellitus (DM) in comparison to the same-age population with DM 10 years previously. METHODS:The study was conducted in baby boomers with DM using data from the National Health and Nutrition Examination S...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000000473
更新日期:2016-06-01 00:00:00
abstract::We have described three cases of adenomyoma of the stomach. These benign lesions are found almost exclusively in the antrum or pylorus and are composed of combinations of ducts, glands, pancreatic tissue, and smooth muscle. Malignancy arising in adenomyomas is rare. ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198410000-00037
更新日期:1984-10-01 00:00:00