Autologous gastro-intestinal reconstruction: the composite ileo-colic loop.

Abstract:

:A reproducible technique was developed experimentally in pigs for construction of a 'composite bowel tube' (CBT) made up of ileal mucosa that was grafted to a mucosally denuded colonic muscle surface vascularised by the colonic mesentery. Macroscopic and microscopic studies at terminal laparotomy revealed a viable, mucosally lined, patent peristaltic loop of bowel in six of the eight animals. Two animals died after sloughing the grafted mucosa. In vivo absorption studies, using l-alanine as an index of amino acid absorption, showed a transport pattern through the grafted mucosa of the composite ileo-colic loop appropriate to ileum when compared with controls. The CBT constitutes another autologous gastro-intestinal reconstructive technique for redistribution of available absorptive mucosa over a longer intestinal length, and may therefore be of benefit in the management of the short-bowel syndrome.

journal_name

Pediatr Surg Int

authors

Bianchi A,Lendon M,Ward ID

doi

10.1007/BF00178430

subject

Has Abstract

pub_date

1996-04-01 00:00:00

pages

248-51

issue

4

eissn

0179-0358

issn

1437-9813

journal_volume

11

pub_type

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