Short- and long-term survival of esophageal cancer patients treated at the Cancer Institute of Iran.

Abstract:

INTRODUCTION:Little data is available on the prognosis of esophageal cancer (EC) in Iran. We studied the short- and long-term survival of EC patients treated at the Cancer Institute of Iran. METHODS:619 patients were followed who had been operated in the years 1997-2006. The 1-month to 5-year survival rates of EC and hazard ratios (HR) for different prognostic factors were estimated. RESULTS:Median survival was 11.5 months and 5-year survival was 10%. Patients at the advanced stage had a 2.1-fold higher risk of mortality compared to the early stage (95% CI 1.2-3.4). One-month mortality decreased from 12.2 in 1997-1999 to 9.1% in 2003-2006. In the first month, patients who were diagnosed in 2003-2006 had a significantly (60%) lower HR compared to 1997-1999 (HR = 0.4, 95% CI 0.1-0.9). In addition, patients with cardiopulmonary complications had an 11.7-fold higher HR compared to patients without complications (95% CI 4.7-29.3). CONCLUSIONS:The 5-year survival rate for operated EC patients was considerably low in Iran. Cardiopulmonary complications were the strong prognostic factors for first-month mortality. We suggest improving the pre- and postoperative care of EC to control these complications. Regular monitoring of patient survival is recommended to evaluate the effect of this intervention.

journal_name

Dig Surg

journal_title

Digestive surgery

authors

Mir MR,Rajabpour MV,Delarestaghi MM,Hadji M,Harirchi I,Mir P,Mir A,Lashkari M,Zendehdel K

doi

10.1159/000354854

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

331-6

issue

4-6

eissn

0253-4886

issn

1421-9883

pii

000354854

journal_volume

30

pub_type

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