Bile changes after liver surgery: experimental and clinical lessons for future applications.

Abstract:

INTRODUCTION:The aim of this review is to summarize the available evidence for changes in bile composition following liver surgery and assess their use in predicting post-operative complications. MATERIALS AND METHODS:A literature search was undertaken for all studies focusing on bile composition, bile volume and analysis. Articles were selected from MEDLINE, Embase and the Cochrane Central Register of Controlled Trials databases up to May 2009. RESULTS:Low values of pre-operative bilirubin diglucuronide predict reduced post-operative liver function and the occurrence of jaundice. Low concentrations of hepatocyte growth factor and interleukin-6 in bile following surgery are associated with the subsequent development of liver failure and are probably surrogate markers for situations where the resultant hepatic regeneration is inadequate. CONCLUSIONS:Analysis of the composition and quality of bile is probably underused as a tool for the pre-operative screening and early post-operative monitoring of patients at high risk of developing liver failure following major hepatobiliary procedures.

journal_name

Dig Surg

journal_title

Digestive surgery

authors

Gravante G,Knowles T,Ong SL,Al-Taan O,Metcalfe M,Dennison AR,Lloyd DM

doi

10.1159/000320459

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

450-60

issue

6

eissn

0253-4886

issn

1421-9883

pii

000320459

journal_volume

27

pub_type

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